Patents by Inventor Maria L. Webb

Maria L. Webb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorescent capture assay for kinase activity employing an anti-phosphotyrosine antibody as both the capture agent and detecting agent
    Patent number: 6806056
    Abstract: A method for determining the level of tyrosine kinase activity in a biological sample is disclosed. The method employs an anti-phosphotyrosine antibody as both the capture agent and the detecting agent. The detecting antibody is labeled with a fluorescent label, for instance, Cy5, Cy5.5 or Cy7 or a lanthanide ion, such as europium, as the signal generating entity. The method is particularly well suited to high throughput screening, for example, for compounds which modulate tyrosine kinase activity.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: October 19, 2004
    Assignee: Pharmacopeia Drug Discovery, Inc.
    Inventors: J. Fraser Glickman, James Inglese, Bassam Damaj, Maria L. Webb, Jonathan J. Burbaum
  • Fluorescent capture assay for kinase activity
    Publication number: 20020177179
    Abstract: A method for determining the level of tyrosine kinase activity in a biological sample is disclosed. The method employs an anti-phosphotyrosine antibody as both the capture agent and the detecting agent. The detecting antibody is labeled with a fluorescent label, for instance, Cy5, Cy5.5 or Cy7 or a lanthanide ion, such as europium, as the signal generating entity. The method is particularly well suited to high throughput screening, for example, for compounds which modulate tyrosine kinase activity.
    Type: Application
    Filed: April 18, 2002
    Publication date: November 28, 2002
    Applicant: Pharmacopiea, Inc.
    Inventors: J. Fraser Glickman, James Inglese, Bassam Damaj, Maria L. Webb, Jonathan J. Burbaum
  • Method for solubilizing membrane receptor proteins
    Patent number: 5151502
    Abstract: A process for solubilizing membrane receptor proteins which includes exposing an outer membrane having the desired protein to an oxidizing agent, treating the membrane with a detergent and treating with an inhibitory material lowering agent. This method maintains the activity of the membrane proteins after solubilization.
    Type: Grant
    Filed: April 30, 1991
    Date of Patent: September 29, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Maria L. Webb, Hossain Monshizadegan