Abstract: The invention concerns an oral pharmaceutical composition comprising either 18 mg or 9 mg of the PDE4B-inhibitor of formula III a therapeutically effective dose of a second active agent selected from the group consisting of nintedanib or pirfenidone and optionally, one or more pharmaceutically acceptable carriers or excipients for the treatment of a patient suffering from a progressive fibrosing interstitial lung disease (PF-ILD), wherein this oral pharmaceutical composition is to be administered to said patient twice daily.

Abstract: The invention concerns an oral pharmaceutical composition consisting essentially of the PDE4B-inhibitor of formula III in the dose of 18 mg or 9 mg and optionally of one or more pharmaceutically acceptable carriers or excipients for use in the treatment of a patient suffering from one or more progressive fibrosing interstitial lung diseases (PF-ILD), wherein this oral pharmaceutical composition is to be administered to the patient twice daily. The invention further concerns oral pharmaceutical compositions comprising the PDE4B-inhibitor of formula III in the dose of 18 mg or 9 mg and a therapeutically effective dose of a second active ingredient selected from nintedanib or pirfenidone, wherein these oral pharmaceutical compositions are administered to the patient twice daily.

Abstract: A nano-catalyst which is usable in processes of vegetable oil hydrogenation for producing bio-lubricants or biodegradable plastics for producing copolymers, characterized in that it consists of an active phase composed of nickel, palladium and ruthenium, dispersed on a support including graphene layers less than 1 micron, the outer surface of which is covered with surfactant chains, and having a high activity and a very high selectivity for the cis-configuration of the 9-octadecenoic acid (cis-oleic acid).

Abstract: A real time radiation dosimeter includes a first electrode and a second electrode, such as cathode and anode electrodes. The second electrode is based on carbon nanomaterials, such as carbon nanotubes bucky paper, carbon nanotubes forest and graphene film. The dosimeter is connected to an electrometer, able to apply a bias voltage between the electrodes and to measure the collected charge. The manufactured detectors display an excellent linear response to dose. The dosimeter with nanotubes forest is able to collect charge also to zero voltage, allowing in vivo applications. The use of nanomaterials allows a miniaturized version of dosimeters.

Abstract: The present invention describes a new synthetic strategy that permits to produce 2D 1D, e OD hybrid organic-inorganic nanocrystals of tungsten/molybdenum chalcogenides. The innovative chemical approach is based on the thermal decomposition of a molecular precursor containing both metal and sulphur, in a mixture of long chain amines and/or fatty acids and/or long chain thiols. By the control of reaction conditions is possible to address the synthesis can be driven towards the formation of nanosystems with different morphologies such as sheets, particles, rods, tubes.

Abstract: The present invention introduces a small-size temperature sensor, which exploits a random or oriented network of un-functionalized, single or multi-walled, carbon nanotubes to monitor a wide range of temperatures. Such network is manufactured in the form of freestanding thin film with an electric conductance proven to be a monotonic function of the temperature, above 4.2 K. Said carbon nanotube film is wire-connected to a high precision source-measurement unit, which measures its electric conductance by a standard two or four-probe technique. Said temperature sensor has a low power consumption, an excellent stability and durability, a high sensitivity and a fast response; its manufacturing method is simple and robust and yields low-cost devices. Said temperature sensor, freely scalable in dimension, is suitable for local accurate measurements of rapidly and widely changing temperatures, while introducing a negligible disturb to the measurement environment.