Abstract: An outer container forms a windowed conduit holding an inner tray aligned within the windowed conduit. A containment membrane is supported in the tray window. A pair of frangible sheathes covering each end of the windowed conduit. The containment membrane is filled with content(s) to be delivered and the membrane secured within the inner tray. The tray is held within the outer container such that the containment membrane is positioned within the container such that it may be eventually delivered through a first outer window. The first outer window is positioned on one side of the container and covered with a first frangible element. A second outer window is aligned with the first window at the opposite side of the container forming the conduit. A second frangible element covers the second window such that the containment membrane sits between the pair of aligned windows.

Abstract: Disclosed herein are methods for identifying a subject as having serrated colorectal cancer (CRC), and models of human serrated CRC. Also provided herein are methods for treating serrated CRC in the subject.

Abstract: The p62 protein has been analyzed and identified as the significant contributor to several metabolic pathways that lead to metabolic syndrome, Alzheimer's Disease, and other related diseases. The absence of the p62 protein has a profound effect on the accumulation of tau protein, amyloid beta protein and an increase in blood insulin levels. The accumulation of tau protein and amyloid beta protein in neurological tissues is a hallmark of neurological metabolic diseases such as Alzheimer's Disease and related dementias. Moreover, increase blood insulin levels is an indicator of insulin resistance in mammals. Accordingly, the present invention provides a method for screening a mammal for metabolic disease comprising the step of detecting the absence of the p62 protein.