Patents by Inventor Maria Victoria Montenegro-Chamorro
Maria Victoria Montenegro-Chamorro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6852484Abstract: The present inventors have discovered that Asparagine Synthase is essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Asparagine Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Asparagine Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: GrantFiled: December 10, 2001Date of Patent: February 8, 2005Assignee: Icoria, Inc.Inventors: Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarper, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd M. DeZwaan
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Patent number: 6806060Abstract: The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: GrantFiled: December 7, 2001Date of Patent: October 19, 2004Assignee: Icoria, Inc.Inventors: Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo
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Publication number: 20040146960Abstract: The present inventors have discovered that Trehalose-6-Phosphate Synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of Trehalose-6-Phosphate Synthase gene expression in fungi results in reduced pathogenicity (i.e. smaller, non-viable lesions). Thus, Trehalose-6-Phosphate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Trehalose-6-Phosphate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: November 7, 2003Publication date: July 29, 2004Inventors: Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Covington, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank
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Patent number: 6740498Abstract: The present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: GrantFiled: December 6, 2001Date of Patent: May 25, 2004Assignee: Paradigm Genetics, Inc.Inventors: Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer
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Patent number: 6733963Abstract: The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: GrantFiled: December 6, 2001Date of Patent: May 11, 2004Assignee: Paradigm Genetics, Inc.Inventors: Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer
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Patent number: 6723529Abstract: The present inventors have discovered that &agr;-Aminoadipate Reductase is essential for fungal pathogenicity. Specifically, the inhibition of &agr;-Aminoadipate Reductase gene expression in fungi results in no signs of successful infection or lesions. Thus, &agr;-Aminoadipate Reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit &agr;-Aminoadipate Reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: GrantFiled: November 9, 2001Date of Patent: April 20, 2004Assignee: Paradigm Genetics, Inc.Inventors: Matthew M. Tanzer, Jeffrey Shuster, Lisbeth Hamer, Kiichi Adachi, Todd M. DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy K. Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey
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Publication number: 20030228650Abstract: The present inventors have discovered that Methylenetetrahydrofolate reductase is essential for fungal pathogenicity. Specifically, the inhibition of Methylenetetrahydrofolate reductase gene expression in fungi results in an inability to form lesions and non-pathogenicity. Thus, Methylenetetrahydrofolate reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Methylenetetrahydrofolate reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: May 13, 2003Publication date: December 11, 2003Inventors: Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, M. DeZwaan Todd, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger
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Publication number: 20030228645Abstract: The present inventors have discovered that Chitin Synthase 2 is essential for fungal pathogenicity. Specifically, the inhibition of Chitin Synthase 2 gene expression in fungi results in no signs of successful infection or lesions. Thus, Chitin Synthase 2 can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Chitin Synthase 2 expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: May 12, 2003Publication date: December 11, 2003Inventors: Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, M. DeZwaan Todd, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro
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Publication number: 20030224472Abstract: The present inventors have discovered that Putrescine Aminopropyltransferase (SPE3) is essential for normal fungal pathogenicity. Specifically, the inhibition of Putrescine Aminopropyltransferase gene expression in fungi results in reduced pathogenicity on their host organism, producing smaller lesions that fail to spread across a leaf surface. Thus, Putrescine Aminopropyltransferase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Putrescine Aminopropyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: May 13, 2003Publication date: December 4, 2003Inventors: Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd M. DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty
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Publication number: 20030224970Abstract: The present inventors have discovered that S-adenosylmethionine decarboxylase (“SPE2”) is essential for normal fungal pathogenicity. Specifically, the inhibition of S-adenosylmethionine decarboxylase gene expression in fungi results in greatly reduced pathogenicity. Thus, S-adenosylmethionine decarboxylase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit S-adenosylmethionine decarboxylase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: May 12, 2003Publication date: December 4, 2003Inventors: Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd M. DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux
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Patent number: 6632631Abstract: The present inventors have discovered that homocitrate synthase is essential for fungal pathogenicity. Specifically, the inhibition of homocitrate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, homocitrate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit homocitrate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: GrantFiled: November 9, 2001Date of Patent: October 14, 2003Assignee: Paradigm Genetics, Inc.Inventors: Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd M. DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy K. Mahanty, Huaqin Pan, Amy Skalchunes, Rex W. Tarpey
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Publication number: 20030186837Abstract: The present inventors have discovered that Asparagine Synthase is essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Asparagine Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Asparagine Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: December 10, 2001Publication date: October 2, 2003Inventors: Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarper, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd M. DeZwaan
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Publication number: 20030180829Abstract: The present inventors have discovered that homocitrate synthase is essential for fungal pathogenicity. Specifically, the inhibition of homocitrate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, homocitrate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit homocitrate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: November 9, 2001Publication date: September 25, 2003Inventors: Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd M. DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy K. Mahanty, Huaqin Pan, Amy Skalchunes, Rex W. Tarpey
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Publication number: 20030148412Abstract: The present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: December 6, 2001Publication date: August 7, 2003Inventors: Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer
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Publication number: 20030143657Abstract: The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: December 6, 2001Publication date: July 31, 2003Inventors: Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer
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Publication number: 20030108979Abstract: The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: December 7, 2001Publication date: June 12, 2003Inventors: Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo
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Publication number: 20030104511Abstract: The present inventors have discovered that &agr;-Aminoadipate Reductase is essential for fungal pathogenicity. Specifically, the inhibition of &agr;-Aminoadipate Reductase gene expression in fungi results in no signs of successful infection or lesions. Thus, &agr;-Aminoadipate Reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit &agr;-Aminoadipate Reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: November 9, 2001Publication date: June 5, 2003Inventors: Matthew M. Tanzer, Jeffrey Shuster, Lisbeth Hamer, Kiichi Adachi, Todd M. DeZwaan, Sze-Chung (clive) Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy K. Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey