Patents by Inventor Marian Major

Marian Major has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis C virus neutralizing antibody
    Patent number: 9399672
    Abstract: A specific epitope on the surface of the hepatitis C virus that induces a neutralizing antibody response in vivo and neutralizing monoclonal antibodies that bind specifically to the epitope are disclosed. The antibodies block hepatitis C virus from infecting cells.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: July 26, 2016
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Hongying Duan, Stephen M. Feinstone, Marian Major, Pei Zhang
  • HEPATITIS C VIRUS NEUTRALIZING ANTIBODY
    Publication number: 20150118242
    Abstract: A specific epitope on the surface of the hepatitis C virus that induces a neutralizing antibody response in vivo and neutralizing monoclonal antibodies that bind specifically to the epitope are disclosed. The antibodies block hepatitis C virus from infecting cells.
    Type: Application
    Filed: May 16, 2013
    Publication date: April 30, 2015
    Inventors: Hongying Duan, Stephen M. Feinstone, Marian Major, Pei Zhang
  • Neutralization of HCV
    Patent number: 8603468
    Abstract: Aspects of the present invention concern compositions that induce and/or improve an immune response to hepatitis C virus (HCV). Methods of making and using compositions that include epitopes of the HCV E2 structural protein involved in promoting or inhibiting neutralization of HCV are provided.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: December 10, 2013
    Assignee: The United States of America, as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Pei Zhang, Marian Major, Stephen Feinstone
  • LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS
    Publication number: 20100247522
    Abstract: Aspects of the present invention concern compositions that induce and/or improve an immune response to hepatitis C virus (HCV). Methods of making and using compositions that include epitopes of the HCV E2 structural protein involved in promoting or inhibiting neutralization of HCV are provided.
    Type: Application
    Filed: November 4, 2008
    Publication date: September 30, 2010
    Inventors: Pei Zhang, Marian Major, Stephen Feinstone
  • Modified HCV peptide vaccines
    Publication number: 20060275322
    Abstract: Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L?A substitution at amino acid position 139, an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2, and a fragment of an HCV core polypeptide having fewer amino acids than the entire HCV core polypeptide and comprising the amino acid sequence of SEQ ID NO: 1. Also provided are nucleic acids which encode the peptides and polypeptides of this invention, vectors comprising the nucleic acids of this invention and cells comprising the vectors and nucleic acids of this invention. Further provided are methods of producing an immune response in a subject and/or treating or preventing HCV infection in a subject, comprising administering to the subject, or to a cell of the subject, any of the compositions of this invention.
    Type: Application
    Filed: May 5, 2006
    Publication date: December 7, 2006
    Inventors: Jay Berzofsky, Pablo Sarobe, Stephen Feinstone, Marian Major
  • Modified HCV peptide vaccines
    Publication number: 20050129705
    Abstract: Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L?A substitution at amino acid position 139, an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2, and a fragment of an HCV core polypeptide having fewer amino acids than the entire HCV core polypeptide and comprising the amino acid sequence of SEQ ID NO:1. Also provided are nucleic acids which encode the peptides and polypeptides of this invention, vectors comprising the nucleic acids of this invention and cells comprising the vectors and nucleic acids of this invention. Further provided are methods of producing an immune response in a subject and/or treating or preventing HCV infection in a subject, comprising administering to the subject, or to a cell of the subject, any of the compositions of this invention.
    Type: Application
    Filed: February 2, 2004
    Publication date: June 16, 2005
    Inventors: Jay Berzofsky, Stephen Feinstone, Marian Major, Pablo Sarobe