Patents by Inventor Mariana Resnicoff

Mariana Resnicoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of tumors with oligonucleotides directed to insulin-like growth factor-I receptors (IGF-IR)
    Patent number: 6541036
    Abstract: A method of inducing resistance to or regression of tumor growth comprising placing tumor cells in culture in vitro or ex vivo supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a diffusion chamber, thereby producing a cell-containing chamber, inserting the chamber into a human for a therapeutically effective time, thereby inducing resistance to or regression of tumor growth.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: April 1, 2003
    Assignee: Thomas Jefferson University
    Inventors: David W. Andrews, Renato L. Baserga, Mariana Resnicoff, David Abraham
  • Method of inducing resistance to tumor growth
    Patent number: 6506415
    Abstract: A method of inducing resistance to tumor growth comprising placing tumor cells in culture in vitro supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a diffusion chamber, thereby producing a cell-containing chamber, inserting the chamber into a mammal for a therapeutically effective time, thereby inducing resistance to tumor growth. The pro-apoptotic agents include nucleic acid molecules, proteins or peptides, non-proteins or non-polynucleotide compounds, and a physical conditions.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: January 14, 2003
    Assignee: Thomas Jefferson University
    Inventors: Renato Baserga, David Abraham, Mariana Resnicoff
  • MHC peptides and methods of use
    Publication number: 20020165136
    Abstract: MHC or HLA Class I peptides and compositions thereof are provided for the specific induction of apoptosis of cancer cells in a patient. Methods of treating cancer cells in patients suffering from cancer employing the MHC or HLA Class I peptides of the invention. Also provided are methods of identifying MHC or HLA Class I peptides and variants thereof capable of killing cancerous cells in vivo in a patient suffering from cancer.
    Type: Application
    Filed: April 17, 2001
    Publication date: November 7, 2002
    Applicant: Thomas Jefferson University
    Inventors: Renato L. Baserga, Mariana Resnicoff, Ziwei Huang
  • Method of inducing resistance to tumor growth
    Patent number: 6312684
    Abstract: A method of inducing resistance to tumor growth comprising placing tumor cells in culture in vitro supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a diffusion chamber, thereby producing a cell-containing chamber, inserting the chamber into a mammal for a therapeutically effective time, thereby inducing resistance to tumor growth. The pro-apoptotic agents include nucleic acid molecules, proteins or peptides, non-proteins or non-polynucleotide compounds, and a physical conditions.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: November 6, 2001
    Assignee: Thomas Jefferson University
    Inventors: Renato Baserga, David Abraham, Mariana Resnicoff
  • Method of inducing resistance to tumor growth
    Publication number: 20010022977
    Abstract: A method of inducing resistance to tumor growth comprising placing tumor cells in culture in vitro supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a diffusion chamber, thereby producing a cell-containing chamber, inserting the chamber into a mammal for a therapeutically effective time, thereby inducing resistance to tumor growth. The pro-apoptotic agents include nucleic acid molecules, proteins or peptides, non-proteins or non-polynucleotide compounds, and a physical conditions.
    Type: Application
    Filed: April 11, 2001
    Publication date: September 20, 2001
    Applicant: Thomas Jefferson University
    Inventors: Renato Baserga, David Abraham, Mariana Resnicoff
  • MHC peptides and methods of use
    Patent number: 6218363
    Abstract: MHC or HLA Class I peptides and compositions thereof are provided for the specific induction of apoptosis of cancer cells in a patient. Methods of treating cancer cells in patients suffering from cancer employing the MHC or HLA Class I peptides of the invention. Also provided are methods of identifying MHC or HLA Class I peptides and variants thereof capable of killing cancerous cells in vivo in a patient suffering from cancer.
    Type: Grant
    Filed: August 28, 1996
    Date of Patent: April 17, 2001
    Assignee: Thomas Jefferson University
    Inventors: Renato L. Baserga, Mariana Resnicoff, Ziwei Huang
  • Inducing resistance to tumor growth with soluble IGF-1 receptor
    Patent number: 6084085
    Abstract: Individuals having tumors are treated with pharmaceutical compositions comprising expression vectors, preferably adenovirus or retroviruses, comprising nucleic acid molecules encoding soluble IGF-1R. Such vectors express soluble IGF-1R in tumor cells resulting in reversal of the transformed phenotype, induction of apoptosis, and inhibition of tumorigenesis.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: July 4, 2000
    Assignee: Thomas Jefferson University
    Inventors: Renato Baserga, Mariana Resnicoff, Consuelo D'Ambrosio, Andre Ferber
  • Method of inducing resistance to tumor growth
    Patent number: 5714170
    Abstract: A method of inducing resistance to tumor growth comprising placing tumor cells in culture supplemented with an agent in a diffusion chamber thereby producing a cell-containing chamber, inserting the chamber into a mammal for a therapeutically effective time, thereby inducing resistance to tumor growth.
    Type: Grant
    Filed: November 16, 1994
    Date of Patent: February 3, 1998
    Assignee: Thomas Jefferson University
    Inventors: Renato Baserga, David Abraham, Mariana Resnicoff