Patents by Inventor Marianne Bruggeman

Marianne Bruggeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mouse ? light chain locus
    Patent number: 7541513
    Abstract: The present invention provides in a first aspect a mouse in which the ?(lambda) light chain locus has been functionally silenced. In one embodiment, the mouse ? light chain locus was functional silenced by deletion of gene segments coding for the ? light chain locus. In a further aspect, a mouse containing functionally silenced ? and ? (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: June 2, 2009
    Assignee: Translocus Limited
    Inventors: Marianne Bruggeman, Xiangang Zou
  • Mouse lambda light chain locus
    Publication number: 20050060763
    Abstract: The present invention provides in a first aspect a mouse in which the ? (lambda) light chain locus has been functionally silenced. In one embodiment, the mouse ? light chain locus was functional silenced by deletion of gene segments coding for the ? light chain locus. In a further aspect, a mouse containing functionally silenced ? and ? (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
    Type: Application
    Filed: June 21, 2002
    Publication date: March 17, 2005
    Inventors: Marianne Bruggeman, Xiangang Zou