Patents by Inventor Marie-Christine Chartier-Harlin

Marie-Christine Chartier-Harlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Implication of a known gene named cp2/lsf-lbp-1 in alzheimer's desease
    Publication number: 20030190631
    Abstract: This invention concerns a method of predicting an increased risk of a human subject of developing Alzheimer's disease comprising assaying for a mutation within the ADN sequence of the CP2/LSF/LBP-1 gene including the region controlling the expression of said gene.
    Type: Application
    Filed: June 27, 2002
    Publication date: October 9, 2003
    Inventors: Marie Christine Chartier-Harlin, Philippe Amovel, Jean-Charles Lambert, Louisa Araria
  • Test and model for Alzheimer's disease
    Publication number: 20030165958
    Abstract: Model systems of Alzheimer's disease comprise a DNA sequence encoding an amyloid precursor protein (APP) isoform or fragment that has an amino acid substitution. The substituted amino acid may be other than valine at the amino acid position corresponding to amino acid residue position 717 of APP770. Methods of determining genetic predisposition to Alzheimer's disease are also disclosed.
    Type: Application
    Filed: February 3, 2003
    Publication date: September 4, 2003
    Applicant: Elan Pharmaceuticals
    Inventors: John Anthony Hardy, Marie-Christine Chartier-Harlin, Alison Mary Goate, Michael John Owen, Michael John Mullan
  • Method for diagnosing Alzheimer disease
    Patent number: 6391553
    Abstract: The invention concerns a method for diagnosing Alzheimer disease, consisting in demonstrating one or several mutations in the genomic DNA region regulating the expression of the apolipoprotein E gene, inducing a modification of the apolipoprotein E gene, with respect to a control population or a modification of the expression relative to the alleles of the apolipoprotein E gene.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: May 21, 2002
    Assignees: Institut Pasteur de Lille, Institut National de la Santa et de la Recherche Medicale (Inserm)
    Inventors: Marie-Christine Chartier-Harlin, Jean-Charles Lambert, Philippe Amouyel
  • Transgenic mouse expressing an APP-FAD DNA sequence
    Patent number: 6300540
    Abstract: Model systems of Alzheimer's disease comprise a DNA sequence encoding an amyloid precursor protein (APP) isoform or fragment that has an amino acid substitution. The substituted amino acid may be other than valine at the amino acid position corresponding to amino acid residue position 717 of APP770. Methods of determining genetic predisposition to Alzheimer's disease are also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 9, 2001
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: John Anthony Hardy, Marie-Christine Chartier-Harlin, Alison Mary Goate, Michael John Owen, Michael John Mullan
  • Genetic markers used jointly for the diagnosis of Alzheimer's disease, and diagnostic method and kit
    Patent number: 5942392
    Abstract: Combined use of at least two genetic markers selected from apolipoprotein E, D19S178 and apolipoprotein CII, for the diagnosis of Alzheimer's disease, especially apolipoprotein .epsilon.4, long apolipoprotein CII (30.+-.3 repeat patterns (CA) and short D19S178 (less than 167.+-.4 nucleotides) alleles. The invention also concerns a method for the diagnosis of Alzheimer's disease and a kit for carrying out said method.
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: August 24, 1999
    Assignees: Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale
    Inventors: Philippe Amouyel, Marie-Christine Chartier-Harlin
  • APP770 mutant in alzheimer's disease
    Patent number: 5877015
    Abstract: Model systems of Alzheimer's disease comprise a DNA sequence encoding an amyloid precursor protein (APP) isoform or fragment that has an amino acid substitution. The substituted amino acid may be other than valine at the amino acid position corresponding to amino acid residue position 717 of APP770. Methods of determining genetic predisposition to Alzheimer's disease are also disclosed.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: March 2, 1999
    Assignee: Imperial College of Science, Technology of Medicine
    Inventors: John Anthony Hardy, Marie-Christine Chartier-Harlin, Alison Mary Goate, Michael John Owen, Michael John Mullan