Patents by Inventor Marie-France Penet

Marie-France Penet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Theranostic imaging agents and methods of use
    Patent number: 10029023
    Abstract: The present invention provides targeted nanoplex molecules which carry multimodality imaging reporters together with target enzyme inhibitors such as siRNAs and target prodrug enzymes, that are useful for theranostic imaging of cells and diseases, including, for example, various cancers, and including metastatic prostate cancer. The nanoplex molecules of the present invention provide a platform technology toward many cancer subtypes and alternative therapeutic targets. Downregulation of specific pathways using targeted enzyme inhibitors further provides unique opportunities to target cancer cells selectively while sparing normal tissue. The nanoplex molecule platform described herein has the ability to deliver multiple siRNA enzyme inhibitors. Methods of diagnosis and treatment of various diseases are also included.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: July 24, 2018
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin Pomper, Zaver Bhujwalla, Zhihang Chen, Cong Li, Sridhar Nimmagadda, Marie-France Penet, Sangeeta Ray
  • THERANOSTIC IMAGING AGENTS AND METHODS OF USE
    Publication number: 20140178300
    Abstract: The present invention provides targeted nanoplex molecules which carry multimodality imaging reporters together with target enzyme inhibitors such as siRNAs and target prodrug enzymes, that are useful for theranostic imaging of cells and diseases, including, for example, various cancers, and including metastatic prostate cancer. The nanoplex molecules of the present invention provide a platform technology toward many cancer subtypes and alternative therapeutic targets. Downregulation of specific pathways using targeted enzyme inhibitors further provides unique opportunities to target cancer cells selectively while sparing normal tissue. The nanoplex molecule platform described herein has the ability to deliver multiple siRNA enzyme inhibitors. Methods of diagnosis and treatment of various diseases are also included.
    Type: Application
    Filed: March 30, 2012
    Publication date: June 26, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin Pomper, Zaver Bhujwalla, Zhihang Chen, Cong Li, Sridhar Nimmagadda, Marie-France Penet, Sangeeta Ray
  • Method of treatment of an inflammatory disorder with a Vanin-1 antagonist
    Publication number: 20040247524
    Abstract: The present invention relates to the screening of Vanin-1 antagonists useful for the treatment of an inflammatory disorder, in particular intestinal inflammation, and to a method treatment of an inflammatory disorder with such a Vanin-1 antagonist.
    Type: Application
    Filed: June 5, 2003
    Publication date: December 9, 2004
    Inventors: Philippe Naquet, Franck Galland, Florent Martin, Max De Reggi, Bouchra Di Reggi, Marie-France Penet, Giuseppina Pitari, Sylvestro Dupre