Abstract: Novel pyrimidine N-oxide compounds and salts thereof, well suited for stimulating the growth of keratin fibers (e.g., the hair or the eyelashes) and/or limiting the loss thereof and/or increasing their density, have the formula (A): in which n is an integer ranging from 2 to 12; R1 is a linear or branched, saturated or unsaturated alkyl radical, optionally substituted with a group —OR?, —NR?R? or —COOR?, R1 having from 1 to 20 carbon atoms, or is NR?R?; R2 is hydrogen, —NR3R4, —OR3, or —SR3, wherein R3 and R4, which may be identical or different, are each a linear or branched, saturated or unsaturated alkyl radical, optionally substituted with a group —OR?, —NR?R? or —COOR?, R2 having from 1 to 20 carbon atoms, with the proviso that R3 and R4 may form part of a saturated or unsaturated ring member of 4 to 7 atoms, optionally containing at least one hetero atom; and R? and R?, which may be identical or different, are each hydrogen or a saturated, linear or branched C1-C3 alkyl radical.

Abstract: The invention concerns the use of an efficient amount of at least an extract of an least a plant of the Olea europaea species in a physiologically acceptable medium, in a composition or for preparing a composition, the extract or composition being designed to inhibit NO-synthase.

Abstract: The invention concerns relates to the use of an efficient amount of lipochroman-6, in a physiologically acceptable medium, in a composition or for preparing a composition, the lipochroman-6 or the composition being designed to inhibit NO-synthase.

Abstract: A method for treating a subject suffering from a disorder associated with NO and/or NO-synthase comprising administering to said subject an effective NO-synthase inhibiting amount of at least one extract of at least one plant of the species Vitis vinifera, in a physiologically acceptable medium.

Abstract: The invention relates to a composition intended for administration by the oral or topical route and comprising, in a physiologically acceptable medium, DHEA and/or a chemical or biological precursor or derivative of the latter, in combination with at least one NO-synthase inhibitor. This composition can be used for cosmetic purposes, for preventing or treating irritation of the skin and/or sensitive skin and/or for signs of cutaneous aging. In an alternative form, it can be used for treating the scalp and/or hair or as reducing composition. The NO-synthase inhibitor can be chosen in particular from: lipochroman-6, a grape extract, an olive tree extract, a Gingko biloba extract or epicatechin.

Abstract: The invention relates to the use of at least one modulator of aquaporin adipose (AQPap) in a cosmetic composition as slimming agent for reducing the volume of adipocytes and for enhancing the departure of glycerol from the adipocytes. It also relates to cosmetic compositions comprising a combination of at least one agent which modulates aquaporin adipose and of at least one lipolytic active agent.

Abstract: Novel pyrimidine N-oxide compounds and salts thereof, well suited for stimulating the growth of keratin fibers (e.g., the hair or the eyelashes) and/or limiting the loss thereof and/or increasing their density, have the formula (A): in which n is an integer ranging from 2 to 12; R1 is a linear or branched, saturated or unsaturated alkyl radical, optionally substituted with a group —OR?, —NR?R? or —COOR?, R1 having from 1 to 20 carbon atoms, or is NR?R?; R2 is hydrogen, —NR3R4, —OR3, or —SR3, wherein R3 and R4, which may be identical or different, are each a linear or branched, saturated or unsaturated alkyl radical, optionally substituted with a group —OR?, —NR?R? or —COOR?, R2 having from 1 to 20 carbon atoms, with the proviso that R3 and R4 may form part of a saturated or unsaturated ring member of 4 to 7 atoms, optionally containing at least one hetero atom; and R? and R?, which may be identical or different, are each hydrogen or a saturated, linear or branched C1-C3 alkyl radical.

Abstract: The present invention relates to the use of N-arylmethylene ethylenediaminetriacetates, N-arylmethylene iminodiacetates or N,N′-diarylmethylene ethylenediamineacetates, their salts or metal complexes to increase the production of nitric oxide in or on the skin or scalp or the mucous membranes as well as a procedure for the application of nitric oxide in or on the skin, the scalp or the mucous membranes. It also relates to a cosmetic treatment procedure which makes use of these compounds as donors of NO.

Abstract: The present invention relates to the use of mono- or di-esters of cinnamic acid or of one of its derivatives and vitamin C, in particular ascorbyl 2-O-cinnamate, to increase the production of nitric oxide in or on the skin or scalp or the mucous membranes as well as a procedure of application of nitric oxide in or on the skin, the scalp or the mucous membranes. It also relates to a cosmetic treatment procedure which makes use of these compounds as donors of NO.

Abstract: N,N′-bis(2-pyridyl)methyl-N,N′-bis(3,4,5-trimethoxybenzyl) ethylenediamine and therapeutic/cosmetic compositions comprised thereof are useful NO-synthase inhibitors, suited, inter alia, for slowing or even inhibiting cell differentiation and/or proliferation, and for inhibiting the degradation and/or destruction of cells.

Abstract: Ascorbyl 2-hexadecanoate and therapeutic/cosmetic compositions comprised thereof are useful NO-synthase inhibitors, suited, inter alia, for slowing or even inhibiting cell differentiation and/or proliferation, and for inhibiting the degradation and/or destruction of cells.

Abstract: The invention relates to a composition intended for administration by the oral or topical route and comprising, in a physiologically acceptable medium, DHEA and/or a chemical or biological precursor or derivative of the latter, in combination with at least one NO-synthase inhibitor.

Abstract: The invention concerns the use of an efficient amount of at least an extract of an least a plant of the Olea europaea species in a physiologically acceptable medium, in a composition or for preparing a composition, the extract or composition being designed to inhibit NO-synthase.

Abstract: The present invention relates to the use of an efficient amount of lipochroman-6, in a physiologically acceptable medium, in a composition or for preparing a composition, the lipochroman-6 or the composition being designed to inhibit NO-synthase.