Abstract: This bioreactor comprises two enclosures (60,62) connected by first and second porous carbon tube (66,68) for the circulation of the nutrient medium (19) and immersed in the culture medium (9), internal mineral, microporous membranes (70) located in each first and second tube for ensuring the passage of the nutrient medium to the culture mdium and whilst serving as a barrier for contaminants, external, mineral, microporous membranes (72) located outside each first and second tube for ensuring the passage of the nutrient medium to the culture medium and while serving as barrier for the cells and the proteins contained in the culture medium, at least one porous mineral tube (86) for the extraction of the substances produced by the cells, which is isolated from the two enclosures and equipped with an external, microporous, mineral membrane impermeable to the cells, but permeable to the macromolecules produced in the culture medium.