Abstract: A machine for forming packing templates includes a infeed mechanism that can feed multiple feeds of sheet material into the machine without repositioning the infeed mechanism or forming creases or bends in the sheet material. The machine also includes a separation and cutting systems with one or more cutting tables and biased knives that cut the sheet material packaging templates. The machine also includes creasing roller(s) that forms creases in the sheet material. The machine also includes a system for reducing or eliminating the impact of irregularities in the sheet material.

Abstract: The disclosure relates to a control device (60A, 60B) for a bicycle (1000), comprising a support body (2) for being fixed to a handlebar (33) of the bicycle (1000), a lever (3) movably arranged relative to the support body (2), and a sensing device arranged to transmit a signal upon actuation thereof. The lever (3) is movable relative to the support body (2) from a neutral position to a braking position for initiating a braking action, and from the neutral position to a first actuation position in which the lever (3) actuates the sensing device. The lever (3) is movable from the neutral position to the braking position in a first direction. The lever (3) is also movable from the neutral position to the first actuation position in a second direction different from the first direction.

Abstract: The invention relates to antibodies against the Platelet Derived Growth Factor Receptor beta (PDGFR ?), and the use thereof in diagnostic and/or therapeutic applications. In particular, it provides a (VHH) antibody that specifically binds PDGFR ? with an apparent binding affinity of less than 10 nM, preferably less than 5 nM, and which does not activate PDGFR ?. Also provided are PDGFR ? antibodies and conjugates thereof, and their application in the targeted delivery of a diagnostic agent, a therapeutic agent or a combination thereof to a tissue in a subject, in particular to fibrotic tissue comprising activated myofibroblasts.

Abstract: The invention relates to the field of medicine. In particular, the present invention relates to the use of 2-iminobiotin for use in the treatment of stroke, wherein 2-iminobiotin is administered in combination with a fibrinolytic drug. The invention in particular relates to the use of 2-iminobiotin for use in the treatment of acute ischemic stroke is due to vessel occlusion eligible for endovascular mechanical thrombectomy.

Abstract: In the measurement of properties of a wafer substrate, such as Critical Dimension or overlay a sampling plan is produced defined for measuring a property of a substrate, wherein the sampling plan comprises a plurality of sub-sampling plans. The sampling plan may be constrained to a predetermined fixed number of measurement points and is used to control an inspection apparatus to perform a plurality of measurements of the property of a plurality of substrates using different sub-sampling plans for respective substrates, optionally, the results are stacked to at least partially recompose the measurement results according to the sample plan.

Abstract: A method may include acquiring NMR data and sonic data for a borehole in a subsurface geologic region; inverting the NMR data and the sonic data to determine volume fractions for a number of classes of pore types, where the classes include shape and size-based classes; and characterizing the subsurface geologic region based on the volume fractions for the number of classes.

Abstract: A multi-channel LED driver for driving an LED fixture, wherein the multi-channel LED driver comprising a plurality of output channels, wherein each output channel is connectable to an LED or LED string of the LED fixture, the multi-channel LED driver comprising: a plurality of power converters, each power converter being associated with an output channel of the plurality of output channels, wherein each power converter comprises a switch, and wherein each power converter converts an input power at an input terminal to a current at a respective output channel of the multi-channel LED driver, a comparator configured to compare a current signal representing the current measured at an output channel by a current measurement element with a reference signal representing a current set point for the output channel, and wherein the comparator generates an output signal to control the switch of the power converter associated with the output channel, a controller arranged to determine successive, for each of the plur

Abstract: Apparatus and methods of forming boxes from template blanks includes moving the blank forward on a drive line while one or more side panel fingers raise and lower various side panels of the blank in an alternating fashion. One or more holders maintain the side panels in position as the blank moves forward on the drive line. The raised and lowered side panels rigidify various panels from which they extend. The rigidified panels may be less susceptible to bending along false scores that extend transversely across the blank during folding and bending steps of the box forming process.

Abstract: Recycled carbon fibers are processed by rotational tumbling in a mixture with binder material to prepare fiber-containing particles having a dual-tapered shape and general alignment of fibers with a longitudinal direction of the particles. Bulk products including such fiber-containing particles are compounded with polymer and pelletized to prepare fiber-reinforced composite pellets, which are useful for applications such as injection molding to prepare molded products of carbon fiber-reinforced composite material with recycled carbon fibers.

Abstract: Provided is an apparatus (100) for transporting sweat droplets (112) to a sensor. The apparatus comprises a chamber (102) for filling with sweat. The chamber has an inlet (104) lying adjacent the surface of the skin (106), which inlet permits sweat to enter and fill the chamber. The chamber has an outlet (114) from which a sweat droplet protrudes once the chamber has been filled. The apparatus further comprises a fluid transport assembly which is designed to enable the sweat droplet protruding from the outlet to become detached from the outlet of the chamber. The sweat droplet is subsequently transported by the fluid transport assembly to the sensor. Once the protruding droplet has been released from the outlet, the outlet is made available for a subsequent sweat droplet to protrude therefrom upon further filling of the chamber.

Abstract: Provided is a system (300) for determining a sweat rate per gland and measuring biomarker concentration. The system comprises an apparatus and a sensor (166). The apparatus receives sweat from the skin and transports the sweat as discrete sweat droplets to the sensor. The sensor senses each of the counted sweat droplets. The system further comprises a processor which counts the number of sensed sweat droplets during a time period. The processor also determines time intervals between consecutive sensed sweat droplets, and receives a measure of the volume of each of the counted sweat droplets. The time intervals and the measure of the volume are then used by the processor to identify sweat burst and rest periods of the sweat gland or glands producing the sweat. This identification process necessarily involves assigning the sweat burst and rest periods to the sweat gland or glands, such that the processor is permitted to determine the number of sweat glands involved in producing the sweat.

Abstract: The present invention relates to a compound of formula (I) or a tautomer thereof, wherein R1, R2, R3, R4 and R5, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of epilepsy and/or neurodegenerative diseases.

Abstract: A one-part room temperature vulcanisable (RTV) silicone composition is provided. The one-part RTV silicone composition comprises a polyorganosiloxane polymer comprising at least two hydrolysable groups per molecule, anhydrous reinforcing filler(s), cross-linker(s), a tin (iv) based condensation catalyst and one or more low molecular weight linear or branched nitrogen containing compounds. The compounds are selected from amidines, guanidines and other alkyl amines and alkyl polyamines. The composition is designed to be storable for at least 6 months at a temperature (T° C.) in a range of between 0° C. and 25° C. inclusive.

Abstract: A system predicts user intent to take an action and delivers content items to the user that match that intent. A plurality of features or attributes for each tracking pixel in a set of tracking pixels can be acquired based on content items and landing pages associated with each tracking pixel. For example, features for a tracking pixel can be determined based on information associated with a content item that enabled a user to access a landing page from which the tracking pixel was fired or triggered. In this example, features for the tracking pixel can also be determined based on information associated with the landing page. The features for the tracking pixels can be utilized to train a machine learning model. The machine learning model can be trained to predict whether or not a particular user intends to produce a conversion (e.g., make a purchase).

Abstract: The invention relates to a hydraulic system for a vehicle transmission, comprising: a hydraulic circuit arranged for generating a pressure, a hydraulic actuator arranged for engaging a park lock system, wherein the hydraulic actuator is hydraulically connected to the hydraulic circuit for actuation of the hydraulic actuator using the pressure, and a back-up system configured to keep the pressure above a predetermined pressure threshold for maintaining an actuation of the hydraulic actuator for a predetermined period of time in case of an operational interruption of a transmission control unit of the vehicle.

Abstract: Disclosed is a compressor of a dual-flow aircraft turboshaft engine extending longitudinally along an axis X, the compressor comprising a low-pressure compressor, a high-pressure compressor and an intermediate casing axially connecting the low-pressure compressor and the high-pressure compressor, the high-pressure compressor comprising an inlet guide stator comprising a retaining ring, an outer high-pressure compressor casing and a plurality of vanes, the compressor comprising an immobilising device comprising at least one first member secured to the intermediate casing and at least one second member secured to the retaining ring and configured to cooperate with the first member in order to prevent tangential movement while allowing axial movement and radial movement of the retaining ring relative to the intermediate casing according to the axis X.