Patents by Inventor Mariena V. Mattson

Mariena V. Mattson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-(1-thienylcycloalkyl)alkenylamines for treatment of neurotoxic injury
    Patent number: 5604255
    Abstract: Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an N-(1-thienylcycloalkyl)alkenylamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula ##STR1## wherein R.sup.1 is one or more groups selected from hydrido, alkyl of one to about five carbon atoms, cycloalkyl of three to about five carbon atoms, alkenyl of two to about five carbon atoms, hydroxyl and alkoxy; wherein each of R.sup.2 is one or more groups selected from hydrido, alkyl of one to about five carbon atoms, cycloalkyl of three to about five carbon atoms, alkenyl of two to about five carbon atoms, hydroxyl, oxo and alkoxy; wherein R.sup.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: February 18, 1997
    Assignees: The United States of America as represented by the Department of Health and Human Services, G. D. Searle & Co.
    Inventors: Kenner C. Rice, Arthur E. Jacobson, Andrew Thurkauf, Mariena V. Mattson, Thomas L. O'Donohue, Patricia C. Contreras, Nancy M. Gray
  • N-(1-thienylcycloalkyl)alkenylamines for treatment of neurotoxic injury
    Patent number: 5401755
    Abstract: Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an N-(1-thienylcycloalkyl)alkenylamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 are defined in specification.
    Type: Grant
    Filed: October 8, 1991
    Date of Patent: March 28, 1995
    Assignees: G. D. Searle & Co., National Institutes of Health
    Inventors: Kenner C. Rice, Arthur E. Jacobson, Andrew Thurkauf, Mariena V. Mattson, Thomas L. O'Donohue, Patricia C. Contreras, Nancy M. Gray
  • 5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treatment of epilepsy and cocaine addiction
    Patent number: 5196415
    Abstract: This invention is in the field of clinical neurology and relates specifically to compounds, compositions and methods for treatment of patients with generalized epilepsy or partial (symptomatic) epilepsy using compounds of the formula: ##STR1## This invention also relates to compounds, compositions and methods of treatment for drug craving in patients addicted to cocaine.
    Type: Grant
    Filed: January 29, 1992
    Date of Patent: March 23, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: James A. Monn, Andrew Thurkauf, Shunichi Yamaguchi, Michael A. Rogawski, Kenner C. Rice, Mariena V. Mattson, Arthur E. Jacobson
  • Metaphit and related compounds as acylating agents for the (3H)phencyclidine receptors
    Patent number: 4762846
    Abstract: A derivative of phencyclidine (1) bearing an isothiocyanate moiety on the meta position of the aromatic ring (3; Metaphit as methanesulfonate and HCl salt) has been synthesized and identified as a rapid and specific site-directed acylating agent of the [.sup.3 H]-phencyclidine binding site in rat brain homogenates. Additional related compounds to Metaphit are Thiophit (oxalate salt), Ethylphit (HCl salt), and Isopropylphit (HCl salt).
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: August 9, 1988
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kenner C. Rice, Michael F. Rafferty, Arthur E. Jacobson, Patricia Contreras, Thomas L. O'Donohue, Ralph A. Lessor, Mariena V. Mattson
  • Metaphit, a specific acylating agent for the [.sup.3 H] phencyclidine
    Patent number: 4598153
    Abstract: A derivative of phencyclidine (1) bearing an isothiocyanate moiety of the meta position of the aromatic ring (2; Metaphit) has been synthesized and identified as a rapid and specific site-directed acylating agent of the [.sup.3 H]-phencyclidine binding site in rat brain homogenates.
    Type: Grant
    Filed: December 19, 1984
    Date of Patent: July 1, 1986
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kenner C. Rice, Michael F. Rafferty, Arthur E. Jacobson, Patricia Contreras, Thomas L. O'Donohue, Ralph A. Lessor, Mariena V. Mattson