Patents by Inventor Marilyn Khanna

Marilyn Khanna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High fidelity detection of nucleic acid differences by ligase detection reaction
    Patent number: 7244831
    Abstract: Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: July 17, 2007
    Assignees: Cornell Research Foundation, Inc., Purdue Research Foundation
    Inventors: Francis Barany, Jianying Luo, Marilyn Khanna, Donald E. Bergstrom
  • High fidelity detection of nucleic acid differences by ligase detection reaction
    Publication number: 20050037346
    Abstract: Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
    Type: Application
    Filed: April 1, 2003
    Publication date: February 17, 2005
    Inventors: Francis Barany, Jianying Luo, Marilyn Khanna, Donald Bergstrom
  • Thermostable DNA ligase mutants
    Patent number: 6576453
    Abstract: Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: June 10, 2003
    Assignees: Cornell Research Foundation, Inc., Purdue Research Foundation
    Inventors: Francis Barany, Jianying Luo, Marilyn Khanna, Donald E. Bergstrom
  • High fidelity detection of nucleic acid differences by ligase detection reaction
    Publication number: 20030082545
    Abstract: Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
    Type: Application
    Filed: August 10, 2001
    Publication date: May 1, 2003
    Inventors: Francis Barany, Jianying Luo, Marilyn Khanna, Donald E. Bergstrom
  • High fidelity detection of nucleic acid differences by ligase detection reaction
    Patent number: 6312892
    Abstract: Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: November 6, 2001
    Assignees: Cornell Research Foundation, Inc., Purdue Research Foundation
    Inventors: Francis Barany, Jianying Luo, Marilyn Khanna, Donald E. Bergstrom