Patents by Inventor Marina Ziche

Marina Ziche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compound B as an angiogenic agent in combination with human growth factors
    Patent number: 7223732
    Abstract: Compound B is shown to promote angiogenesis, specifically, budding of capillaries. The combination of Compound B and with human growth factor, such as bFGF, shows synergistic angiogenetic effects.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: May 29, 2007
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Marina Ziche, Silvia Donini, Francesco Borelli
  • Polypeptides derived from endostatin exhibiting antiangiogenic activity
    Patent number: 6921749
    Abstract: Polypeptides with sequence corresponding or homologous to that of endostatin, having inhibiting activity on angiogenesis, are useful in the treatment of angiogenesis-dependent tumors.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: July 26, 2005
    Assignees: Universita' Degli Studi di Milano, Universita' Degli Studi di Firenze
    Inventors: Francesco Chillemi, Pierangelo Francescato, Marina Ziche
  • Compound B as an angiogenic agent in combination with human growth factors
    Publication number: 20050153892
    Abstract: The present invention refers to the use of Compound B as angiogenic agent in combination with human growth factors.
    Type: Application
    Filed: December 10, 2004
    Publication date: July 14, 2005
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Marina Ziche, Silvia Donini, Francesco Borrelli
  • Nitric oxide donors based on metallic centers
    Patent number: 6897218
    Abstract: A metal complex of a piperazineNONOate derivative of the formula: wherein a) R1 and R2 independently represent hydrogen, linear or branched (C1-C4) alkyl, optionally substituted by 1 or 2 groups selected from the group consisting of hydroxy, (C1-C4) alkoxy, (C1-C4) alkylthio, amino, (C1-C4) alkylamino, di-(C1-C4) alkylamino, carboxy, carbo(C1-C4) alkoxy, aryl, aryloxy, arylthio; or b) R1 and R2 taken together, represent one of the following groups ?CR3-aryl, where R3 represents hydrogen, (C1-C4) linear or branched chain alkyl, optionally substituted by 1 or 2 groups selected from the group consisting of hydroxy, carboxy, aryl; n represents a whole number ranging from 2 to 4; M+ represents a cation of a transition metal or zinc; x represents a whole number which varies from 1 to 3, and indicates the charge units of the cation of the transition metal or of the zinc in relation to its stable oxidation state; A ? represents an inorganic or organic anion which forms stable salts with the NONOate metal complex
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: May 24, 2005
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Luigi Casella, Marina Ziche
  • Compound B as angiogenic agent in combination with human growth factors
    Patent number: 6855684
    Abstract: The present invention refers to the use of Compound B as angiogenic agent in combination with human growth factors.
    Type: Grant
    Filed: January 9, 2001
    Date of Patent: February 15, 2005
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Marina Ziche, Silvia Donini, Francesco Borrelli
  • Nirtic oxide donors based on metallic centres
    Publication number: 20040029854
    Abstract: The invention relates to ligand complexes characterised by the presence of a piperazineNONOate residue with metal cations where the cations derive from a transition metal or zinc in a stable oxidation state. These complexes are nitric oxide donors and exert an endothelio-protective effect on the coronary district and stimulate re-endothelialization and angiogenesis processes. The invention comprises a preparation process and the therapeutic use of said compounds.
    Type: Application
    Filed: April 23, 2003
    Publication date: February 12, 2004
    Inventors: Luigi Casella, Marina Ziche
  • Compound B as angiogenic agent in combination with human growth factors
    Publication number: 20010031733
    Abstract: The present invention refers to the use of Compound B as angiogenic agent in combination with human growth factors.
    Type: Application
    Filed: January 9, 2001
    Publication date: October 18, 2001
    Inventors: Marina Ziche, Silvia Donini, Francesco Borrelli