Patents by Inventor Mario Huesca

Mario Huesca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl imidazoles and their use as anti-cancer agents
    Patent number: 10080739
    Abstract: Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: September 25, 2018
    Assignee: Aptose Biosciences Inc.
    Inventors: Mario Huesca, Raed Al-Qawasmeh, Aiping H. Young, Yoon Lee, Lisa Lock
  • SMALL MOLECULE INHIBITORS OF GP120-MEDIATED HIV INFECTION AND METHODS OF USE
    Publication number: 20180179166
    Abstract: Small molecule inhibitors GP120-mediated HIV infections, methods for identifying the same, and methods and uses employing of these compounds in treatment, inhibition or prevention of HIV infection are provided. The compounds have a structure according to Formula (I), and comprise a pharmacophore functionally corresponding with pharmacophore (I) of FIG. 2.
    Type: Application
    Filed: March 24, 2015
    Publication date: June 28, 2018
    Inventors: Clifford LINGWOOD, Mario HUESCA, Raveendra DAYAM, Shamshair SINGH
  • 2-SUBSTITUTED IMIDAZO[4,5-D]PHENANTHROLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER
    Publication number: 20160176876
    Abstract: The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumour cells or non-small cell lung cancer cells.
    Type: Application
    Filed: February 29, 2016
    Publication date: June 23, 2016
    Inventors: Yoon LEE, Howard CUKIER, Venkata NEDUNURI, Robert PERALTA, Mario HUESCA, Aiping H. YOUNG
  • 2-substituted imidazo[4,5-D]phenanthroline derivatives and their use in the treatment of cancer
    Patent number: 9309247
    Abstract: The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumor cells or non-small cell lung cancer cells.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: April 12, 2016
    Assignee: LORUS THERAPEUTICS INC.
    Inventors: Yoon Lee, Howard Cukier, Venkata Nedunuri, Robert Peralta, Mario Huesca, Aiping H. Young
  • 2-SUBSTITUTED IMIDAZO[4,5-D]PHENANTHROLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER
    Publication number: 20160031883
    Abstract: The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumour cells or non-small cell lung cancer cells.
    Type: Application
    Filed: March 20, 2014
    Publication date: February 4, 2016
    Inventors: Yoon LEE, Howard CUKIER, Venkata NEDUNURI, Robert PERALTA, Mario HUESCA, Aiping H. YOUNG
  • ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS
    Publication number: 20150374669
    Abstract: Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents.
    Type: Application
    Filed: January 22, 2015
    Publication date: December 31, 2015
    Inventors: Mario HUESCA, Raed AL-QAWASMEH, Aiping H. YOUNG, Yoon LEE, Lisa LOCK
  • 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents
    Patent number: 8987305
    Abstract: The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: March 24, 2015
    Assignee: Aptose Biosciences Inc.
    Inventors: Raed H. Al-Qawasmeh, Aiping H. Young, Mario Huesca, Yoon S. Lee
  • Aryl imidazoles and their use as anti-cancer agents
    Patent number: 8969372
    Abstract: Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: March 3, 2015
    Assignee: Aptose Boisciences Inc.
    Inventors: Mario Huesca, Raed Al-Qawasmeh, Aiping H. Young, Yoon Lee
  • 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS
    Publication number: 20130177632
    Abstract: The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
    Type: Application
    Filed: February 27, 2013
    Publication date: July 11, 2013
    Inventors: Raed H. Al-Qawasmeh, Aiping H. Young, Mario Huesca, Yoon S. Lee
  • 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents
    Patent number: 8394815
    Abstract: The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: March 12, 2013
    Assignee: Lorus Therapeutics Inc.
    Inventors: Raed H. Al-Qawasmeh, Aiping H. Young, Mario Huesca, Yoon S. Lee
  • 2-indolyl imidazo [4,5-d] phenanthroline derivatives and their use in the treatment of cancer
    Patent number: 8148392
    Abstract: 2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula (I) and methods of using same in the treatment of cancer, in particular, solid cancers and leukemia are provided. Pharmaceutical compositions comprising the compounds are also provided.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: April 3, 2012
    Assignee: Lorus Therapeutics Inc.
    Inventors: Mario Huesca, Aiping H. Young, Yoon Lee, Aye Aye Khine, Jim A. Wright, Lisa Lock, Raed Al-Qawasmeh
  • 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS
    Publication number: 20110152337
    Abstract: The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
    Type: Application
    Filed: December 22, 2010
    Publication date: June 23, 2011
    Applicant: LORUS THERAPEUTICS INC.
    Inventors: RAED H. AL-QAWASMEH, AIPING H. YOUNG, MARIO HUESCA, YOON S. LEE
  • 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents
    Patent number: 7884120
    Abstract: The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: February 8, 2011
    Assignee: Lorus Therapeutics Inc.
    Inventors: Raed Al-Qawasmeh, Aiping H. Young, Mario Huesca, Yoon Lee
  • 2-Indolyl Imidazo [4,5-d] Phenanthroline Derivatives and Their Use in the Treatment for Cancer
    Publication number: 20100168417
    Abstract: 2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula I that are capable of intracellular chelation of transition metals and of exerting antiproliferative effects in cancer cells, that are cytostatic and/or cytotoxic, are provided. Compounds of Formula I can also induce apoptosis in cancer cells and are thus capable of exerting a cytotoxic effect on cancer cells. The compounds of Formula I are also capable of selectively inhibiting the proliferation of one or more of prostate cancer cells, colon cancer cells, non-small lung cancer cells and leukemia cells. The compounds of Formula I are also capable of increasing the expression of the zinc-regulated tumour suppressor, KLF4 and thus are useful in inhibiting the proliferation of cancer cells in which KLF4 functions as a tumour-suppressor, including, but not limited to, bladder cancer, cancers of the gastrointestinal tract and various leukemias.
    Type: Application
    Filed: May 25, 2006
    Publication date: July 1, 2010
    Inventors: Mario Huesca, Aiping H. Young, Yoon Lee, Aye Aye Khine, Jim A. Wright, Lisa Lock, Raed Al-Qawasmeh
  • Aryl imidazoles and their use as anti-cancer agents
    Publication number: 20080262015
    Abstract: Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents.
    Type: Application
    Filed: November 15, 2004
    Publication date: October 23, 2008
    Applicant: LORUS THERAPEUTICS INC.
    Inventors: Mario Huesca, Raed Al-Qawasmeh, Aiping Young, Yoon Lee
  • Aryl imidazoles and their use as anti-cancer agents
    Publication number: 20070123553
    Abstract: Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents.
    Type: Application
    Filed: November 15, 2004
    Publication date: May 31, 2007
    Applicant: LORUS THERAPEUTICS INC.
    Inventors: Mario Huesca, Raed Al-Qawasmeh, Aiping Young, Yoon Lee