Patents by Inventor Mario I. Romero-Ortega
Mario I. Romero-Ortega has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230338029Abstract: A nerve regeneration system includes a nerve guide having a proximal end and a distal end. The system includes nerve growth factor configured to enhance the growth of axons and associated nerve tissue. The nerve growth factor has a first concentration nearer to a proximal end and a second growth factor concentration nearer to a distal end. The second growth factor concentration is higher than the first growth factor concentration. The system includes myelination factor configured to enhance myelination of the grown axons. The myelination factor has a first myelination factor concentration nearer to the proximal end, a third myelination factor concentration nearer to the distal end, and a second myelination factor concentration between the first myelination factor concentration and the third myelination factor concentration. The second myelination factor concentration is higher than the first myelination factor and higher than the third myelination factor concentration.Type: ApplicationFiled: April 5, 2023Publication date: October 26, 2023Inventors: Mario I. Romero-Ortega, David Constantine, Jeffrey Petruska
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Publication number: 20230149709Abstract: A method and/or system controls bladder function of a patient having a symptom related to overactive bladder (OAB) or stress unitary incontinence (SUI). The symptom related to OAB is produced by a natural OAB signal generated by the patient's body. To that end, the method couples an electrode to a prescribed somatic motor nerve (e.g., the perineal nerve) associated with the pelvic floor, and then transmits, via the electrode, an OAB control signal to the prescribed somatic motor nerve. The OAB control signal is configured to activate the pelvic floor in a prescribed manner to mitigate the effect of the natural OAB signal on the pelvic floor.Type: ApplicationFiled: November 12, 2022Publication date: May 18, 2023Inventors: Mario I. Romero-Ortega, David Constantine
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Publication number: 20220305253Abstract: The present disclosure provides methods of making and applying metalized graphene fibers in bioelectronics applications. For example, platinized graphene fibers may be used as an implantable conductive suture for neural and neuro-muscular interfaces in chronic applications. In some embodiments, an implantable electrode includes a multi-layer graphene-fiber core, an insulative coating surrounding the multi-layer graphene-fiber core, and a metal layer disposed between the multi-layer graphene-fiber core and the insulative coating.Type: ApplicationFiled: March 17, 2022Publication date: September 29, 2022Inventors: Mario I. Romero-Ortega, Gordon G. Wallace, Maria Gonzalez-Gonzalez, Rouhollah Ali Jalili
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Patent number: 11260147Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.Type: GrantFiled: May 11, 2020Date of Patent: March 1, 2022Assignee: Board of Regents, The University of Texas SystemInventors: Mario I. Romero-Ortega, Parisa Lotfi, Benjamin R Johnston, Swarupnarayan Dash, Joselito Razal, Gordon Wallace
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Publication number: 20200268934Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.Type: ApplicationFiled: May 11, 2020Publication date: August 27, 2020Inventors: Mario I. ROMERO-ORTEGA, Parisa LOTFI, Benjamin R. JOHNSTON, Swarupnarayan DASH, Joselito RAZAL, Gordon WALLACE
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Publication number: 20200237867Abstract: In one aspect, methods of promoting asymmetric nerve growth and/or regeneration are described herein. In some embodiments, such a method comprises exposing a population of transected or severed nerves to a first molecular growth cue and to a second molecular growth cue. The population of transected nerves comprises one or more nerves of a first nerve type and one or more nerves of a second nerve type differing from the first nerve type. Additionally, the first molecular growth cue preferentially promotes growth of the first nerve type, as compared to the second nerve type. Similarly, the second molecular growth cue preferentially promotes growth of the second nerve type, as compared to the first nerve type. Moreover, the first molecular growth cue is spatially separated from the second molecular growth cue.Type: ApplicationFiled: October 12, 2018Publication date: July 30, 2020Inventors: Mario I ROMERO-ORTEGA, Sanjay ANAND, Nesreen ALSMADI, Geetanjali S BENDALE
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Patent number: 10646617Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.Type: GrantFiled: March 5, 2018Date of Patent: May 12, 2020Assignee: Board of Regents, The University of Texas SystemInventors: Mario I. Romero-Ortega, Parisa Lotfi, Benjamin R. Johnston, Swarupnarayan Dash, Joselito Razal, Gordon Wallace
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Publication number: 20190290902Abstract: In one aspect, a neuromodulation device is described herein. In some embodiments, a neuromodulation device comprises a chamber operable to receive a nerve, at least one electrode disposed in the chamber, and a channel defined by two walls. In some embodiments, the channel of the device is in fluid communication with an interior of the chamber and an external surface of the device. In another aspect, methods of neuromodulation are described herein. In some embodiments, methods described herein can use one or more neuromodulation devices described herein.Type: ApplicationFiled: May 16, 2019Publication date: September 26, 2019Applicant: Board of Regents, The University of Texas SystemInventors: Mario I. ROMERO-ORTEGA, Margarita MARTINEZ-GOMEZ
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Publication number: 20190143102Abstract: In one aspect, a neuromodulation device is described herein. In some embodiments, a neuromodulation device comprises a chamber operable to receive a nerve, at least one electrode disposed in the chamber, and a channel defined by two walls. In some embodiments, the channel of the device is in fluid communication with an interior of the chamber and an external surface of the device. In another aspect, methods of neuromodulation are described herein. In some embodiments, methods described herein can use one or more neuromodulation devices described herein.Type: ApplicationFiled: November 9, 2018Publication date: May 16, 2019Inventors: Mario I. ROMERO-ORTEGA, Stuart F. COGAN, Aswini KANNEGANTI
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Publication number: 20180193521Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.Type: ApplicationFiled: March 5, 2018Publication date: July 12, 2018Inventors: Mario I. ROMERO-ORTEGA, Parisa LOTFI, Benjamin R. JOHNSTON, Swarupnarayan DASH, Joselito RAZAL, Gordon WALLACE
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Patent number: 9950099Abstract: In one aspect, nerve growth inhibition devices are described herein. In some embodiments, a nerve growth inhibition device described herein comprises a tube having a proximal end and a distal end. A matrix material is disposed in the tube, and the matrix material comprises one or more microchannels. The proximal end of the tube comprises an opening operable to receive nerve tissue, the distal end of the tube is sealed, and the microchannels of the matrix material extend from the proximal end of the tube toward the distal end of the tube.Type: GrantFiled: February 18, 2014Date of Patent: April 24, 2018Assignee: Board of Regents, The University of Texas SystemInventors: Mario I. Romero-Ortega, Rafael Granja-Vasquez
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Patent number: 9931432Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.Type: GrantFiled: February 18, 2014Date of Patent: April 3, 2018Assignee: Board of Regents, The University of Texas SystemInventors: Mario I. Romero-Ortega, Parisa Lotfi, Benjamin R. Johnston, Swarupnarayan Dash, Joselito Razal, Gordon Wallace
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Publication number: 20160000965Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.Type: ApplicationFiled: February 18, 2014Publication date: January 7, 2016Inventors: Mario I. ROMERO-ORTEGA, Parisa LOTFI, Benjamin R. JOHNSTON, Swarupnarayan DASH, Joselito RAZAL, Gordon WALLACE
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Publication number: 20150374887Abstract: In one aspect, nerve growth inhibition devices are described herein. In some embodiments, a nerve growth inhibition device described herein comprises a tube having a proximal end and a distal end. A matrix material is disposed in the tube, and the matrix material comprises one or more microchannels. The proximal end of the tube comprises an opening operable to receive nerve tissue, the distal end of the tube is sealed, and the microchannels of the matrix material extend from the proximal end of the tube toward the distal end of the tube.Type: ApplicationFiled: February 18, 2014Publication date: December 31, 2015Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Mario I. ROMERO-ORTEGA, Rafael GRANJA-VAZQUEZ
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Publication number: 20080300691Abstract: A biomimetic biosynthetic nerve implant (BNI) casting device includes a matrix casting tube; a matrix casting tube protective shield comprising a male coupling portion joinable to a female coupling portion, wherein the joined portions encase the matrix casting tube; microchannel forming fibers; a fixing point for holding one end of the microchannel forming fibers; loading fiber guideholes for placement of the microchannel forming fibers; one or more ports for injection of matrix material into the casting tube; and a cell suspension loading well in fluid communication with the matrix casting tube when the device is fully assembled such that removing the fibers from the formed implant can draw fluid containing cells and/or other agents into the microchannels.Type: ApplicationFiled: November 13, 2007Publication date: December 4, 2008Applicant: Texas Scottish Rite Hospital for ChildrenInventors: Mario I. Romero-Ortega, Pedro Galvan-Garcia
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Publication number: 20030049839Abstract: A cell growth scaffold provides individual cell growth channels in a transparent body for microscopic observation of cells during growth.Type: ApplicationFiled: August 1, 2002Publication date: March 13, 2003Applicant: The University of Texas SystemInventors: Mario I. Romero-Ortega, Mauricio R. Delgado-Ayala, Pedro J. Galvan, Hua Liu