Patents by Inventor Mario Michieletti

Mario Michieletti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of pteridine derivatives
    Patent number: 8809553
    Abstract: The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: August 19, 2014
    Assignee: Dipharma Francis S.r.l.
    Inventors: Emanuele Attolino, Mario Michieletti, Davide Rossi, Pietro Allegrini
  • PROCESS FOR THE PREPARATION OF PTERIDINE DERIVATIVES
    Publication number: 20130090474
    Abstract: The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.
    Type: Application
    Filed: June 13, 2011
    Publication date: April 11, 2013
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Emanuele Attolino, Mario Michieletti, Davide Rossi, Pietro Allegrini
  • PROCESS FOR THE PREPARATION OF FOSINOPRIL AND INTERMEDIATES THEREOF
    Publication number: 20120142939
    Abstract: The present invention relates to a process for the preparation of intermediates useful in the synthesis of [1[S(R)],2?,4?]-4-cyclohexyl-1-[[[2-methyl-1-oxypropoxy)propoxy](4-phenylbutyl phosphinyl]acetyl]L-proline, and the synthesis thereof, in particular as sodium salt (fosinopril sodium).
    Type: Application
    Filed: November 1, 2011
    Publication date: June 7, 2012
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Pietro ALLEGRINI, Emanuele ATTOLINO, Alessandro DE MARCO, Fausto GORASSINI, Mario MICHIELETTI
  • Process for the preparation of Sitagliptin
    Patent number: 8097724
    Abstract: A process for the preparation of a compound of formula (I) such as 2(R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]-7(8H)-pyrazinyl]-1-(2,4,5-trifluorophenyl)-2-butanamine, or a salt thereof, in the anhydrous or hydrated form, either as a mixture of enantiomers, or as a single (R) or (S) enantiomer, comprising the conversion of a compound of formula (II), or a salt thereof, either as a single (R) or (S) enantiomer or as a mixture thereof wherein X is hydrogen, hydroxy, C1-C8 alkyl, C1-C4 alkoxy, aryl, amino, N3 or halogen; into a compound of formula (I), and if desired, the separation of a single enantiomer of formula (I) from the racemic mixture, and/or, if desired, the conversion of a compound of formula (I) into a salt thereof, or vice versa.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: January 17, 2012
    Assignee: Dipharma Francis S.r.l.
    Inventors: Pietro Allegrini, Emanuele Attolino, Gianmaria Dell'Anna, Mario Michieletti
  • PROCESS FOR THE PREPARATION OF SITAGLIPTIN
    Publication number: 20100331541
    Abstract: A process for the preparation of 2(R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]-7(8H)-pyrazinyl]-1-(2,4,5-trifluorophenyl)-2-butanamine and intermediates useful for the synthesis thereof.
    Type: Application
    Filed: March 19, 2010
    Publication date: December 30, 2010
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Pietro ALLEGRINI, Emanuele ATTOLINO, Gianmaria DELL'ANNA, Mario MICHIELETTI
  • PROCESS FOR THE SYNTHESIS OF FOSINOPRIL AND INTERMEDIATES THEREOF
    Publication number: 20100297711
    Abstract: Process for the preparation of intermediates useful in the synthesis of [1[S(R)],2?,4?]-4-cyclohexyl-1-[[[(2-methyl-1-oxypropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline, and the synthesis thereof, in particular as sodium salt.
    Type: Application
    Filed: May 24, 2010
    Publication date: November 25, 2010
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Gabriele RAZZETTI, Sergio Riva, Pietro Allegrini, Mario Michieletti, Emanuele Attolino