Publication number: 20040043382
Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
Type:
Application
Filed:
March 7, 2002
Publication date:
March 4, 2004
Inventors:
Muralidhara Padigaru, Kimberly A. Spytek, Suresh G. Shenoy, Raymond J. Taupier, Carol E. A. Pena, Li Li, Bryan D. Zerhusen, Vladimir Y. Gusev, Weizhen Ji, Linda Gorman, Charles E. Miller, Ramesh Kekuda, Meera Patturajan, Esha A. Gangolli, Corine A.M. Vernet, Xiaojia Sasha Guo, Velizar T. Tchernev, Elma R. Fernandes, Stacie J. Casman, Uriel M. Malyankar, Valerie Gerlach, Yi Liu, David W. Anderson, Steven K. Spaderna, Elina Catterton, Mario W. Leite, Haihong Zhong, John P. Alsobrook, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess
Publication number: 20040043928
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
August 1, 2002
Publication date:
March 4, 2004
Inventors:
Ramesh Kekuda, Charles E. Miller, Meera Patturajan, Carol E. A. Pena, Daniel K. Rieger, Richard A. Shimkets, Bryan D. Zerhusen, Li Li, Weizhen Ji, Muralidhara Padigaru, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Linda Gorman, Mario W. Leite, Corine A.M. Vernet, David W. Anderson, Xiaojia Sasha Guo, Mei Zhong, Valerie Gerlach, Luca Rastelli, Tord Hjalt, Kimberly A. Spytek, Shlomit R. Edinger, Karen Ellerman, Uriel M. Malyankar, John R. MacDougall, David J. Stone, John P. Alsobrook, Denise M. Lepley, Catherine E. Burgess, Kumud Majumder, Adam R. Wolenc, Glennda Smithson, Jason C. Baumgartner
Publication number: 20040038230
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
November 4, 2002
Publication date:
February 26, 2004
Inventors:
John P. Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, John S. Chant, Andrei Chapoval, Amitabha Chaudhuri, Shlomit R. Edinger, Andrew Eisen, Esha A. Gangolli, Valerie Gerlach, Xiaojia Sasha Guo, Weizhen Ji, Nikolai V. Khramtsov, Mario W. Leite, Li Li, Peter S. Mezes, Isabelle Millet, Chean Eng Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Luca Rastelli, Daniel K. Rieger, Kerry E. Quinn Senger, Glennda Smithson, Steven K. Spaderna, Kimberly A. Spytek, David J. Stone, Nancy Twomlow, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Mei Zhong
Publication number: 20040030110
Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
Type:
Application
Filed:
April 2, 2002
Publication date:
February 12, 2004
Inventors:
Xiaojia (Sasha) Guo, Ramesh Kekuda, Charles E. Miller, Uriel M. Malyankar, Kimberly A. Spytek, Meera Patturajan, Xiaohong Liu, Vladimir Y. Gusev, Li Li, Corine A.M. Vernet, Bryan D. Zerhusen, Linda Gorman, Suresh G. Shenoy, Carol E. A. Pena, Glennda Smithson, Catherine E. Burgess, Valerie Gerlach, Muralidhara Padigaru, Richard A. Shimkets, Esha A. Gangolli, Raymond J. Taupier, Stacie J. Casman, Weizhen Ji, David W. Anderson, Mario W. Leite, Luca Rastelli, Shlomit R. Edinger, David J. Stone, John R. MacDougall, Mark E. Rothenberg, Ann Mazur, Isabelle Millet, John A. Peyman, Karen Ellerman
Publication number: 20040018555
Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
Type:
Application
Filed:
June 3, 2002
Publication date:
January 29, 2004
Inventors:
David W. Anderson, Bryan D. Zerhusen, Li Li, Mei Zhong, Stacie J. Casman, Valerie Gerlach, Richard A. Shimkets, Linda Gorman, Carol E. A. Pena, Ramesh Kekuda, Meera Patturajan, Kimberly A. Spytek, Mario W. Leite, Luca Rastelli, John R. MacDougall, Raymond J. Taupier, Xiaojia Sasha Guo, Charles E. Miller, Suresh G. Shenoy, Tord Hjalt, Edward Z. Voss, Ferenc L. Boldog, Uriel M. Malyankar, Muralidhara Padigaru, Weizhen Ji, Glennda Smithson, Shlomit R. Edinger, Isabelle Millet, Karen Ellerman
Publication number: 20040014053
Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
August 1, 2002
Publication date:
January 22, 2004
Inventors:
Bryan D. Zerhusen, Meera Patturajan, Ramesh Kekuda, Charles E. Miller, Daniel K. Rieger, Carol E.A. Pena, Richard A. Shimkets, Li Li, Constance Berghs, Mei Zhong, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Muralidhara Padigaru, Glennda Smithson, Weizhen Ji, Linda Gorman, Corine A.M. Vernet, Mario W. Leite, Xiaojia Sasha Guo, David W. Anderson, Kimberly A. Spytek, Valerie Gerlach, Catherine E. Burgess, Nikolai V. Khramtsov, Tatiana Ort, Karen Ellerman, Luca Rastelli, Michele L. Agee, Amitabha Chaudhuri, John S. Chant, Vincent A. DiPippo, Shlomit R. Edinger, Andrew J. Eisen, Esha A. Gangolli, Loic Giot, Chean Eng Ooi, Mark E. Rothenberg, Steven K. Spaderna, Tord Hjalt, Xiaohong Liu, Raymond J. Taupier, Elina Catterton, Suresh G. Shenoy