Patents by Inventor Marioara Mendelovici

Marioara Mendelovici has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline ziprasidone HCl and processes for preparation thereof
    Patent number: 7678799
    Abstract: Provided is crystalline ziprasidone HCl and processes for preparation thereof.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: March 16, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Anna Balanov, Judith Aronhime, Boaz Gome, Tamas Koltai, Natalia Shenkar, Marioara Mendelovici, Ehud Amir
  • Processes for preparation of ziprasidone
    Patent number: 7667037
    Abstract: Provided are processes for preparing ziprasidone from CEI and BIPT.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: February 23, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Gideon Pilarsky, Natalia Shenkar, Marioara Mendelovici, Tamar Nidam, Anna Balanov
  • METHODS FOR PREPARING ESZOPICLONE CRYSTALLINE FORM A, SUBSTANTIALLY PURE ESZOPICLONE AND OPTICALLY ENRICHED ESZOPICLONE
    Publication number: 20100029943
    Abstract: The present invention provides methods for preparing eszopiclone Form A, substantially chemically pure eszopiclone, or eszopiclone with low level(s) of residual solvent(s). The present invention also provides eszopiclone with low level(s) of residual solvent(s). The present invention also provides a process for optical enrichment of eszopiclone free base. For instance, one of the embodiments of the invention is directed to a method of preparing eszopiclone Form A, wherein the method comprises crystallizing eszopiclone free base from a solvent selected from the group consisting of isopropanol (IPA), methyl isobutyl ketone (MIBK), acetone, n-butanol, i-butanolisobutanol, 2-butanol, tetrahydrofuran (THF), dimethyl carbonate, methanol, ethanol, ethyl lactate, dimethylformamide (DMF), carbon tetrachloride, toluene, iso-butyl acetate and mixtures thereof.
    Type: Application
    Filed: September 24, 2009
    Publication date: February 4, 2010
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Marioara MENDELOVICI, Anita LIBERMAN, Alex MAINFELD, Nina FINKELSTEIN
  • Processes for preparing sertraline
    Patent number: 7518018
    Abstract: Provided are processes for the preparation of sertraline and sertraline hydrochloride.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: April 14, 2009
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Harish Ranjan, Sanjay Nayal, Pankaj Singh, Vinod Kumar Kansal, Marioara Mendelovici
  • Polymorphs of eszopiclone malate
    Publication number: 20090076272
    Abstract: The present invention provides crystalline Eszopiclone malate form II, crystalline Eszopiclone form V, processes from preparing the crystalline Eszopiclone malate form II or V, pharmaceutical compositions comprising the crystalline Eszopiclone malate form II or V and methods of treating insomnia comprising administering the crystalline Eszopiclone malate form II or V.
    Type: Application
    Filed: November 7, 2008
    Publication date: March 19, 2009
    Inventors: Marioara Mendelovici, Anita Lieberman, Tamas Koltai
  • Racemization process of R-zopiclone
    Publication number: 20090018336
    Abstract: In one of the embodiments, the present invention provides a racemization process comprising: removing the organic solvent from a mother liquor comprising R-zopiclone malate, eszopiclone malate and an organic solvent to obtain a mixture of R-zopiclone malate and eszopiclone malate; mixing the mixture with water to obtain a solution; neutralizing R-zopiclone malate and eszopiclone malate in the solution to obtain a precipitate of R-zopiclone and eszopiclone; filtering the precipitate; mixing the precipitate of R-zopiclone and eszopiclone with DBU and an organic inert solvent having a boiling point of at least 80° C.; heating; and cooling to obtain a zopiclone racemate.
    Type: Application
    Filed: June 25, 2008
    Publication date: January 15, 2009
    Inventors: Nina Finkelstein, Marioara Mendelovici
  • Methods for preparing eszopiclone
    Publication number: 20080287447
    Abstract: Methods for the preparation of crystalline eszopiclone free base in water, in the absence of organic solvents, are provided. The methods are more environmentally acceptable than prior art methods, and produce eszopiclone free base essentially free of residual organic solvent.
    Type: Application
    Filed: January 31, 2008
    Publication date: November 20, 2008
    Inventors: Nina Finkelstein, Marioara Mendelovici, Revital Ramaty, Alex Mainfeld
  • Amorphous eletriptan hydrobromide and process for preparing it and other forms of eletriptan hydrobromide
    Publication number: 20080287519
    Abstract: The invention encompasses amorphous eletriptan hydrobromide, processes for preparing it and pharmaceutical compositions of it. The invention also relates to processes for preparing other forms of eletriptan hydrobromide such as Form ? and Form ?.
    Type: Application
    Filed: May 1, 2008
    Publication date: November 20, 2008
    Inventors: Marioara Mendelovici, Eli Lancry, Rinat Moshkovits-Kaptsan
  • Sertraline hydrochloride form II and methods for the preparation thereof
    Publication number: 20080287550
    Abstract: The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be produced from sertraline hydrochloride solvate and hydrate forms, and crystallized from new solvent systems. Pharmaceutical compositions containing sertraline hydrochloride Form II and methods of treatment using such pharmaceutical compositions are also disclosed.
    Type: Application
    Filed: May 2, 2008
    Publication date: November 20, 2008
    Inventors: Eduard Schwartz, Tamar Nidam, Anita Liberman, Marioara Mendelovici, Judith Aronhime
  • Amorphous ziprasidone mesylate
    Publication number: 20080214566
    Abstract: Provided is amorphous form of ziprasidone mesylate and process for its preparation. Also provided is a process for preparing ziprasidone mesylate dihydrate needle crystals.
    Type: Application
    Filed: May 2, 2008
    Publication date: September 4, 2008
    Inventors: Judith Aronhime, Marioara Mendelovici, Sigalit Levi, Alex Mainfeld, Amir Gold
  • Processes for preparing sertraline
    Publication number: 20080183015
    Abstract: Provided are processes for the preparation of sertraline and sertraline hydrochloride.
    Type: Application
    Filed: January 9, 2008
    Publication date: July 31, 2008
    Inventors: Harish Ranjan, Sanjay Nayal, Pankaj Singh, Vinod Kumar Kansal, Marioara Mendelovici
  • Sertraline hydrochloride polymorphs
    Publication number: 20080176949
    Abstract: The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X may be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.
    Type: Application
    Filed: March 21, 2008
    Publication date: July 24, 2008
    Inventors: Eduard Schwartz, Tamar Nidam, Anita Liberman, Marioara Mendelovici, Judith Aronhime, Claude Singer, Evgeni Valdman
  • Processes for preparation of polymorphic form II of sertraline hydrochloride
    Publication number: 20080161607
    Abstract: Provided are processes for preparation of crystalline sertraline hydrochloride Form II substantially free of other polymorphic forms of sertraline hydrochloride, preferably on an industrial scale.
    Type: Application
    Filed: March 5, 2008
    Publication date: July 3, 2008
    Inventors: Ronen Borochovitch, Marioara Mendelovici, Tamar Nidam, Ruth Tenengauzer, Julia Hrakovsky, Judith Aronhime
  • Processes for preparing sertraline
    Publication number: 20080114071
    Abstract: Provided are processes for the preparation of sertraline and sertraline hydrochloride.
    Type: Application
    Filed: January 9, 2008
    Publication date: May 15, 2008
    Inventors: Harish Ranjan, Sanjay Nayal, Pankaj Singh, Vinod Kumar Kansal, Marioara Mendelovici
  • Processes for preparing sertraline
    Publication number: 20080114188
    Abstract: Provided are processes for the preparation of sertraline and sertraline hydrochloride.
    Type: Application
    Filed: January 9, 2008
    Publication date: May 15, 2008
    Inventors: Harish Ranjan, Sanjay Nayal, Pankaj Singh, Vinod Kumar Kansal, Marioara Mendelovici
  • Polymorphic form B2 of ziprasidone base
    Publication number: 20080091018
    Abstract: Provided is a crystalline form of ziprasidone base and processes for its preparation.
    Type: Application
    Filed: December 4, 2007
    Publication date: April 17, 2008
    Inventors: Judith Aronhime, Marioara Mendelovici, Tamas Koltai, Rinat Moshkovits-Kaptsan, Tamar Nidam
  • Polymorphic forms of ziprasidone HCl and processes for their preparation
    Publication number: 20080090835
    Abstract: Provided are various polymorphic forms of ziprasidone HCl and processes for their preparation.
    Type: Application
    Filed: December 3, 2007
    Publication date: April 17, 2008
    Inventors: Tamas Koltai, Lilach Hedvati, Marioara Mendelovici, Tamar Nidam
  • Polymorphic forms of ziprasidone HCI and processes for their preparation
    Publication number: 20080091020
    Abstract: Provided are various polymorphic forms of ziprasidone HCl and processes for their preparation.
    Type: Application
    Filed: December 3, 2007
    Publication date: April 17, 2008
    Inventors: Tamas Koltai, Lilach Hedvati, Marioara Mendelovici, Tamar Nidam
  • Polymorphic form B2 of Ziprasidone base
    Publication number: 20080091019
    Abstract: Provided is a crystalline form of ziprasidone base and processes for its preparation.
    Type: Application
    Filed: December 4, 2007
    Publication date: April 17, 2008
    Inventors: Judith Aronhime, Marioara Mendelovici, Tamas Koltai, Rinat Moshkovits-Kaptsan, Tamar Nidam
  • Polymorphic form B2 of ziprasidone base
    Publication number: 20080091017
    Abstract: Provided is a crystalline form of ziprasidone base and processes for its preparation.
    Type: Application
    Filed: December 4, 2007
    Publication date: April 17, 2008
    Inventors: Judith Aronhime, Marioara Mendelovici, Tamas Koltai, Rinat Moshkovits-Kaptsan, Tamar Nidam