Patents by Inventor Marios M. Polycarpou

Marios M. Polycarpou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7857976
    Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller can monitor patient parameters, such as heart rate and blood pressure, and adjust the pumping rates accordingly. The supervisory controller uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller corrects temporal variations in the flow rate based upon an adaptive law and a control law.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: December 28, 2010
    Assignee: Children's Hospital Medical Center
    Inventors: John J. Bissler, Marios M. Polycarpou, Nat Hemasilpin, Efrain O. Morales
  • Patent number: 7785463
    Abstract: A system, program product and method continuously optimize an ultrafiltration rate during an extracorporeal renal replacement process by modeling physiological and actual rate data. The system maps the sensed, physiological data to a mathematical model to assess the data in terms of the ultrafiltration rate. The model provides parameters used to predict where the treatment is headed based on current conditions. The system processes the parameters in terms of preset criteria to generate the optimized ultrafiltration rate. Where the system is networked, communication of the data may be accomplished using remote and online communication techniques.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: August 31, 2010
    Assignee: Children's Hospital Medical Center
    Inventors: John J. Bissler, Nat Hemasilpin, Marios M. Polycarpou
  • Publication number: 20100038317
    Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller can monitor patient parameters, such as heart rate and blood pressure, and adjust the pumping rates accordingly. The supervisory controller uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller corrects temporal variations in the flow rate based upon an adaptive law and a control law.
    Type: Application
    Filed: October 19, 2009
    Publication date: February 18, 2010
    Applicant: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventors: John J. Bissler, Marios M. Polycarpou, Nat Hemasilpin, Efrain O. Morales
  • Patent number: 7539580
    Abstract: A computer implemented method for examining data from a chemical analyzer for artifactual results is provided. A set of rules are established to identify artifactual results based upon experience with the analyzer. Each rule can be associated with a sample collection or testing problem which potentially caused the artifactual result. Using these rules, output data from the analyzer can be tested to see if any of the rules are satisfied. If a rule is satisfied, then an artifactual result can be indicated, as well as the potential cause of the artifactual result. An output file can be created which indicates the artifactual data samples and the potential artifactual causes. The rules file and output file may be provided in a user-friendly format, such as in a spreadsheet or database application format.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: May 26, 2009
    Assignee: University of Cincinnati
    Inventors: Amadeo J. Pesce, Marios M. Polycarpou, Zhong Wang, Goce Dimeski, Peter Hickman
  • Patent number: 6925391
    Abstract: A method and apparatus for examining data from a chemical analyzer for artifactual results. A set of rules are established to identify artifactual results based upon experience with the analyzer. Moreover, each rule can be associated with a sample collection or testing problem which potentially caused the artifactual result. Using these rules, output data from the analyzer can be tested to see if any of the rules are satisfied. If a rule is satisfied, then an artifactual result can be indicated, as well as the potential cause of the artifactual result. An output file can be created which indicates the artifactual data samples and the potential artifactual causes. Preferably, the rules are provided in a user-modifiable data file, so that the rules may be modified based upon additional experience.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: August 2, 2005
    Assignees: University of Cincinnati, The State of Queensland
    Inventors: Amadeo J. Pesce, Marios M. Polycarpou, Zhong Wang, Goce Dimeski, Peter Hickman
  • Patent number: 6780322
    Abstract: A multipurpose hemofiltration system (10) and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system (10) continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller (160) can monitor patient parameters, such as heart rate (120) and blood pressure (130), and adjust the pumping rates accordingly. The supervisory controller (160) uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller (162) corrects temporal variations in the flow rate based upon an adaptive law and a control law.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: August 24, 2004
    Assignee: Children's Hospital Medical Center
    Inventors: John J. Bissler, Marios M. Polycarpou, Nat Hemasilpin, Efrain O. Morales