Abstract: The present invention relates to a non-destructive method comprising placing a tissue sample on a porous matrix, centrifuging the tissue sample under a negative pressure, applying a vacuum on the tissue sample, and collecting extracted extracellular vesicles from the tissue sample. The method does not cause physical rupturing of the tissue sample and maintains integrity of the tissue sample for further histopathological analysis. Moreover, the invention also provides a method of inducing an immune response of a host by immune sensitization using harvested extracellular vesicles.

Abstract: A visualization fluid composition is provided to enhance visualization and analysis of samples. The visualization fluid composition includes a low molecular weight ester, ether, or formate moiety, a volatile organic liquid chemical component, stabilization components, preservation components; and an image color adjusting moiety.

Abstract: Laser Capture Microdissection devices and methods are provided. A Laser Capture Microdissection device contains a transmissive film and a transfer film. The transmissive film includes a first material configured to transmit laser energy. The transfer film includes a second material configured to absorb UV-laser energy. The transfer film contains an absorptive substance to absorb UV-laser energy and convert it into heat.

Abstract: A liquid including an organic component, a stabilization component, and a preservation component is provided. The organic component, the stabilization component, and the preservation component are different components. The organic component present in the liquid includes a volatile organic solution with a refractive index of 1.5 or below. Further, the liquid is a visualization solution that provides a resolving power of a lens by 1/1.5.

Abstract: An embodiment relates to a reagent buffer comprising a zwitterionic sulfonic solution, a non-ionic surfactant solution, and a buffer solution, wherein the reagent buffer has a pH range of about 7.0 to about 8.0 and a circular dichroism with an absorbance peak more than 0 at 190 nm and 225 nm. In an embodiment, the reagent buffer is configured to be a reagent buffer for a lateral flow immunoassay for detection of COVID-19.