Abstract: Provided herein are apparatuses, systems, and methods useful for continuous thermolysis of carbonaceous matter. In certain aspects and embodiments, the invention presents continuous thermolysis of carbonaceous matter in a controlled temperature and steam environment to produce a low volatility char, with subsequent steam activation of the char under pressure producing activated carbon and pressurized syn-gas, all of which are carried out in a reactor system including one or more vessels. The syn-gas is enriched in hydrogen in a high temperature shift reactor and separated in a pressurized swing adsorber to provide a pressurized pure hydrogen stream and a low-pressure combustible tail gas.

Abstract: Snapshots from a first LSU (R1) on a first storage system (A1) may be replicated to a second replica LSU (R2) on a second storage system (A2), for example, concurrently to remotely replicating (e.g., synchronously) write operations for R1 to R2. A process, P, on A1 executing the replication of the snapshots from R1 to R2 may be a separate process than the one or more processes on A1 executing remote replication of write operations for R1 to R2. During a consistency window on A1, outstanding write operations for R1 at the time the consistency window opened may be logged, and a pair of snapshots, SS11 and SS12 may be activated on R1 and R2, respectively. After the consistency window has closed, the SS12 snapshot metadata and snapshot data may be updated based on the outstanding write operations.

Abstract: The present disclosure provides platforms, systems, media, and methods for capturing clinical cases and expert-derived treatment rationales to facilitate biomedical decision making, which can include virtual clinical trials that continuously learn from the experiences of all patients, on all treatments, and all the time. Algorithms such as Bayesian machine learning methods can be applied to coordinate such virtual trials.

Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

Abstract: Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.

Abstract: A filtration system includes an air cleaner housing and a filter element. The air cleaner housing includes a base and a removable cover. At least one of the base or the cover defines a cavity and a protrusion extending into the cavity. The filter element is disposed within the cavity. The filter element includes a plurality of media blocks each including a pleated filter media. The plurality of media blocks are arranged in arch shapes of approximately equal inner radii. The plurality of media blocks are coupled to each other along opposing edges that extend along a pleat direction of the pleated filter media. The media blocks together define at least one void that extends along the protrusion. The protrusion occupies a portion of the void.

Abstract: The present disclosure provides methods and diagnostic tools comprising classifiers and indicator cells that respond differentially to a sample derived from a subject having a disease or cancer, such as lung cancer, as compared to a control or normal sample. Also disclosed herein are methods of detecting a multicomponent gene expression readout from a genetically identical population of cells.

Abstract: A pumping system for performing a borehole operation including pumping a fluid into a borehole. The system may include a motor, a transmission, a pump, and a control system. The motor, transmission, and pump may each include sensors. The transmission may be operatively coupled to the motor. The pump may be operatively coupled to the transmission and configured to pump fluid into the borehole. The control system may be in communication with the motor sensors, the transmission sensors, and the pump sensors. The control system may be configured to monitor the operation of the motor, the transmission, and the pump, determine if at least one of the motor, the transmission, or the pump is operating outside of predetermined parameters, and determine at least one component of the motor, the transmission, or the pump that is most likely to cause the operation to be outside of the predetermined parameters.

Abstract: The invention provides an improved fishing guide, specifically the tip top guide style. The guide consists of a single continuous piece of wire, bent in a manner to create a guide foot, guide ring, an elbow where the wires remain parallel after bending away from the vertical guide foot either inwards towards the guide ring, or outwards away from the guide ring, and a barrier on the rear portion of the guide above the guide foot that prevents the line from sliding between the two wires emerging from the guide foot. This protects the line from pinch points that are common in tip top style guides made of a single wire.

Abstract: A forming system includes a femtosecond laser and a control unit that includes one or more processors operatively connected to the femtosecond laser. The femtosecond laser is configured to emit laser pulses onto an inner surface of a face sheet of an acoustic inner barrel. The acoustic inner barrel includes an acoustic core comprising an array of hexagonal cells attached to an outer surface of the face sheet that is opposite the inner surface. The control unit is configured to control the femtosecond laser to laser drill a plurality of perforations in the face sheet via emitting laser pulses at pulse durations between about 100 femtoseconds and about 10,000 femtoseconds and at frequencies over 100,000 Hz.

Abstract: The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a body portion, a first endplate, and a second endplate, the first and second endplates capable of being moved in a direction away from the body portion into an expanded configuration or capable of being moved towards the body portion into an unexpanded configuration. The fusion device is capable of being deployed and installed in both configurations.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: Antenna elements include a metallic square ring patch and a metallic square ring slot to transmit or receive radio frequency (RF) signals. The antenna elements use several dielectric layers that are separated by a low-dielectric foam layer upon which the square ring patch is positioned. The antenna elements may be arranged into an antenna array that is tunable to collectively generate or receive RF signals to and from airborne and mobile vehicles with an agile, electronically scanning antenna array beam, with no moving parts. The antenna array includes a top section to communicate RF signals; a bottom section to generate a desired RF signal; and a foam layer between the top and bottom sections to separate the ring patch from the ring slot. High isolation between the top section and the bottom section allows the antenna elements to be used in higher gain and high-power arrays without adverse feedback issues.

Abstract: A joint spacer therapeutically maintains separation of bones of a joint. A carriage is slideably retained within the frame and has at least one ramped surface. An actuator screw is threadably engaged with the frame, and rotatably connected to the carriage, to cause the carriage to slideably move within the frame when the actuator screw is rotated. First and second endplates engage the bones of the joint, and each has at least one ramped surface that is mateable with the ramped surface of the carriage, whereby when the carriage is slideably moved by rotation of the actuator screw, the endplates ramped surface slides against the carriage ramped surface to cause the endplates to move along an axis transverse to the longitudinal axis of the frame, to increase the height of the spacer. Piercing elements are connected to the carriage to pierce bone of the joint when the carriage is moved.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: A document handler system and method includes timed operation functionality in which the manufacturer of the document handler may input coded information in the document handler to establish a timed operation of the document handler which may be contingent on continued payments for use of the document handler. Alternatively, or in addition, the timed operation may be used to establish an appropriate warranty period during which the manufacturer is obligated to provide repairs, modification and/or support for the document handler.

Abstract: A reinforcing system for a vessel that can contain water is described. The system includes a shell for containing water, the shell having one or more jets extending therethrough from an inside of the shell to an outside of the shell, and a structural support layer on an underside of the shell. The structural support layer can include: an inner layer of rigidizer applied to the underside of the shell, a central low density core, and an outer layer of rigidizer applied to the central low-density core. The structural support layer can extend from a bottom side of the underside of the shell, across at least one sidewall of the underside of the shell, and form at least one rib along the sidewall of the underside of the shell.

Abstract: An air handling unit has an interior wall configured to selectively retain a removable component of the air handling unit. An air handling unit has an interior wall configured as a drain pan. An air handling unit has an outer skin joined to the interior wall, an insulator disposed between the interior wall and the outer skin, and the interior wall has a mounting channel configured to selectively retain a removable component of the air handling unit.

Abstract: Systems and methods for the dynamic selection of IP address in email platforms, and the synchronization of hostnames and IP addresses in such platforms, are disclosed.

Abstract: The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a body portion, a first endplate, and a second endplate, the first and second endplates capable of being moved in a direction away from the body portion into an expanded configuration or capable of being moved towards the body portion into an unexpanded configuration. The fusion device is capable of being deployed and installed in both configurations.