Patents by Inventor Mark A. Perrella

Mark A. Perrella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN LUNG STEM CELLS AND USES THEREOF
    Publication number: 20130216508
    Abstract: Embodiments of the invention relate to human stem cells and their therapeutic use in the treatment and/or prevention of lung diseases. Provided herein are compositions comprising c-kit positive human lung stem cells and methods of preparing and using c-kit positive human lung stem cells for the treatment and/or prevention of lung diseases.
    Type: Application
    Filed: October 5, 2011
    Publication date: August 22, 2013
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Piero Anversa, Mark Perrella, Annarosa Leri, Jan Kajstura
  • METHODS OF TREATING CARDIAC DISORDERS
    Publication number: 20110044947
    Abstract: The invention feature methods and compositions for treating ischemic and reperfusuin related injury such as cardiac disorders.
    Type: Application
    Filed: March 25, 2010
    Publication date: February 24, 2011
    Inventors: Victor Dzau, Luis G. Melo, Mark A. Perrella, Reitu Agrawal
  • Inhibiting formation of atherosclerotic lesions
    Publication number: 20090012020
    Abstract: The invention features a method of inhibiting formation of atherosclerotic lesions by administering to a mammal, e.g., a human patient who has been identified as suffering from or at risk of developing atherosclerosis, a compound that reduces expression or activity of AFABP.
    Type: Application
    Filed: June 4, 2007
    Publication date: January 8, 2009
    Inventors: Mu-En Lee, Mei Lee, Edgar Haber, Carol Haber, Mark A. Perrella, Gokhan S. Hotamisligil
  • Methods of treating cardiac disorders
    Publication number: 20070258951
    Abstract: The invention feature methods and compositions for treating ischemic aand reperfusuin related injury such as cardiac disorders.
    Type: Application
    Filed: November 20, 2006
    Publication date: November 8, 2007
    Inventors: Victor Dzau, Luis Melo, Mark Perrella, Reitu Agrawal
  • Methods of treating cardiac disorders
    Publication number: 20030022870
    Abstract: The invention feature methods and compositions for treating ischemic aand reperfusuin related injury such as cardiac disorders.
    Type: Application
    Filed: June 3, 2002
    Publication date: January 30, 2003
    Inventors: Victor Dzau, Luis G. Melo, Mark A. Perrella, Reitu Agrawal
  • Regulation of vascular smooth muscle cell heme oxygenase-1
    Patent number: 5888982
    Abstract: The invention features a method of inhibiting sepsis-associated hypotension in a mammal which includes the steps of identifying a mammal suffering from or at risk of developing sepsis and administering to the mammal a compound which inhibits expression of inducible heme oxygenase (HO-1). Also disclosed are screening assays useful for identifying a compound capable of inhibiting HO-1 expression or enzymatic activity.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: March 30, 1999
    Assignee: President and Fellows of Harvard College
    Inventors: Mark A. Perrella, Mu-En Lee