Abstract: An emergency evacuation system is configured to be stored in a compartment below an exit door of an aircraft. The emergency evacuation system includes a first floatation device including an internal inflator, and a second floatation device including an open inflation system. The second floatation device is coupled to the first floatation device.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain aldehyde dehydrogenase inhibitor compounds (also referred to herein as “ALDHI compounds”), that, inter alia, inhibit aldehyde dehydrogenase enzyme ALDH1A3. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit ALDH1A3 enzyme; to treat disorder (e.g., diseases) that are ameliorated by the inhibition of ALDHIA3 enzyme; to treat a proliferative disorder, cancer, obesity, diabetes, a cardiovascular disorder, etc.

Abstract: Embodiments of negative pressure wound therapy systems and methods are disclosed. In one embodiment, an apparatus includes a wound dressing, negative pressure source, user interface, sensor, and control circuitry. The user interface can receive an activation input. The sensor can detect whether the wound dressing is positioned over a wound. The control circuitry can cause supply of negative pressure in response to receipt of the activation input and a determination that the sensor detects that the wound dressing is positioned over the wound. In addition, the control circuitry can prevent supply of negative pressure in response to a determination that the sensor does not detect that the wound dressing is positioned over the wound.

Abstract: Disclosed herein are systems and methods for neural interfaces. Neural interfaces may form minimally invasive and high-scalable bidirectional brain-computer interfaces, which may be used in the treatment of a variety of disorders of the brain and nervous system. Disclosed are methods for a minimally invasive technique for implanting neural interfaces, a neural interface configured to be placed between the brain and the dura and configured to record from and/or stimulate the cortical surface. Also disclosed are methods for attaching a plurality of microelectrode arrays to form a neural interface device, and fabricating neural interfaces including microelectrode arrays and pockets to facilitate their insertion. The disclosed systems and methods also include neural decoding techniques.

Abstract: A housing of a device comprises a screw boss that extends outwardly from a first base plate proximate to a corner of the housing. Additionally, the housing of the device includes a force dissipation member. The force dissipation member includes a central portion that is sized to detachably attach around the screw boss. The force dissipation member further includes at least two arms that extend outwardly from the central portion, wherein each arm of the at least two arms is attached to a different side of the two walls of the housing.

Abstract: A needle-free injector system includes a needle-free injector configured to deploy a dose of a treatment to a patient as an injection event, a gyroscope configured to monitor an orientation of the needle-free injector during the injection event, and a processor configured to perform steps of detecting that an actuator of the needle-free injector has deployed the dose in the injection event, monitoring a signal from the gyroscope during the injection event, determining an orientation of the needle-free injector during the injection event based on the signal from the gyroscope, determining whether the injection event was a treatment event including a successful delivery of the dose to the patient based on the orientation of the needle-free injector during the injection event, and transmitting information regarding the injection event to a server.

Abstract: Low carbon dioxide-emitting processes and systems for steam cracking hydrocarbons to produce products such as ethylene are described. The processes and systems involve cracking the feed in a furnace that is configured to burn a hydrogen-rich fuel, which produces less carbon dioxide than methane, which is typically used as fuel for such furnaces. The hydrogen-rich stream can be isolated and recycled from the cracker tail gas.

Abstract: A system, method, and computer-readable medium are disclosed for browser based polling of jobs used to build a web page of a web application. A web browser builds the web page of the web application and connects with one or more web services for jobs used to build the web page of the web application. A reusable service from a library is downloaded and is used at the web browser to poll the jobs as they are received from the web services. Polling the jobs is performed until download is complete. The web page application is updated when the download is complete.

Abstract: Methods for restoring blood flow in occluded blood vessels using an apparatus having a self-expandable distal segment that is pre-formed to assume a superimposed structure in an unconstrained condition but can be made to take on a volume-reduced form making it possible to introduce it with a microcatheter and a push wire arranged at the proximal end, with the distal segment in its superimposed structure assuming the form of a longitudinally open tube and having a mesh structure of interconnected strings or filaments or struts. In a preferred embodiment, the distal segment has a tapering structure at its proximal end where the strings or filaments or struts converge at a connection point.

Abstract: Devices, systems, and methods for delivering an expandable member to a treatment site within a blood vessel are disclosed herein. According to some embodiments, a delivery system includes a core member and a coupling assembly carried by the core member. The coupling assembly may include an engagement member configured to engage an inner surface of an expandable member extending over the coupling assembly to facilitate delivery of the expandable member from an elongated shaft and/or resheathing of the expandable member into the elongated shaft. The engagement member can be movable between a radially compressed configuration and a radially expanded configuration.

Abstract: Expandable devices for occluding bifurcation aneurysms are disclosed herein. Several of the embodiments are directed towards an expandable device comprising a mesh configured to be deployed at a treatment site including blood vessel bifurcation of a human patient so that the mesh extends across a neck of an aneurysm and prevents or limits blood flow through the mesh and into the aneurysm. The mesh can comprise one or more circumferentially discontinuous portions so that, when the device is deployed at the treatment site, the device does not substantially impede flow from a parent blood vessel to two or more branching blood vessels. Systems and methods for delivering an expandable device of the present technology are also disclosed herein.

Abstract: Field-configurable optical devices and methods are disclosed. In one example, a field-configurable optical device includes a housing defining an enclosure, an input port located at the housing, a pass-through port located at the housing, a plurality of output ports located at the housing, a splitter disposed within the enclosure, a plurality of couplers within the enclosure, each coupler including an input, a first output, and a second output. Each coupler has a power splitting ratio between the first output and the second output that is different from the other couplers. An input port fiber optic jumper assembly within the enclosure. A pass-through port fiber optic jumper assembly is within the enclosure. Moving the input port fiber optic jumper assembly and the pass-through port fiber optic jumper assembly from a first coupler to a second coupler of the plurality of couplers changes the power splitting ratio of the field-configurable optical device.

Abstract: Devices for treating vascular defects and associated systems and methods are disclosed herein. In some embodiments, for example, an occlusive device for treating an aneurysm includes a tubular structure having a first end portion with a first opening, a second end portion with a second opening, and a mesh surface extending between the first and second end portions. The occlusive device also includes a plurality of spiral struts coupled to the first end portion of the tubular structure and extending over the first opening. When the occlusive device is deployed within the aneurysm, the tubular structure and the plurality of spiral struts can be configured to self-expand such that the plurality of spiral struts span a neck of the aneurysm substantially within a single plane and the mesh surface of the tubular structure engages a wall of the aneurysm near the neck.

Abstract: The present disclosure concerns a bearing for a piston rod body for a drug delivery device. The bearing has an axis and comprises a first and a second surface which are spaced apart in the direction of the axis and a third surface, wherein the third surface connects the first and the second surface, wherein an opening is provided in each of the first and the third surface, and wherein the opening in the first surface is connected to the opening in the third surface. Further, the present disclosure concerns a piston rod body and a piston rod arrangement comprising said bearing and the piston rod body.

Abstract: Methods for restoring blood flow in occluded blood vessels using an apparatus having a self-expandable distal segment that is pre-formed to assume a superimposed structure in an unconstrained condition but can be made to take on a volume-reduced form making it possible to introduce it with a microcatheter and a push wire arranged at the proximal end, with the distal segment in its superimposed structure assuming the form of a longitudinally open tube and having a mesh structure of interconnected strings or filaments or struts. In a preferred embodiment, the distal segment has a tapering structure at its proximal end where the strings or filaments or struts converge at a connection point.

Abstract: The present invention pertains an onboard device for checking the quality of DEF in a work machine, comprising a flow channel configured to fluidly connect a DEF inlet with a DEF tank. The flow channel comprises a DQS configured to be brought into contact with DEF passing through the flow channel.

Abstract: A system, method, and computer-readable medium are disclosed for browser based polling of jobs used to build a web page of a web application. A web browser builds the web page of the web application and connects with one or more web services for jobs used to build the web page of the web application. A reusable service from a library is downloaded and is used at the web browser to poll the jobs as they are received from the web services. Polling the jobs is performed until download is complete. The web page application is updated when the download is complete.

Abstract: Methods for restoring blood flow in occluded blood vessels using an apparatus having a self-expandable distal segment that is pre-formed to assume a superimposed structure in an unconstrained condition but can be made to take on a volume-reduced form making it possible to introduce it with a microcatheter and a push wire arranged at the proximal end, with the distal segment in its superimposed structure assuming the form of a longitudinally open tube and having a mesh structure of interconnected strings or filaments or struts. In a preferred embodiment, the distal segment has a tapering structure at its proximal end where the strings or filaments or struts converge at a connection point.

Abstract: Compounds of formula (I): wherein Het, Het1, Het2, A4, A5, Z1, R1, R2 and R3 are as defined in the description. Medicaments.