Abstract: Embodiments of the disclosure include devices and systems for using an end effector. In an embodiment, a medical device may include an articulation section. The articulation section may be operatively associated with an elongate articulation member configured to move the articulation section, wherein the articulation section can be configured to receive part of a conductive member. The medical device may also include an end effector. The end effector may include an electrode and a non-conductive section encasing a junction between the electrode and the conductive member, wherein the non-conductive section can be moveably coupled to the articulation section and can be fixedly coupled to the elongate articulation member.

Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Abstract: The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provided cationic lipids that are useful for preparing the compositions of the invention.

Abstract: The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provided cationic lipids that are useful for preparing the compositions of the invention.

Abstract: A loading basket is secured at its proximal end to a portion of a delivery device. The stent engages with the interior of the stent basket when loaded onto the delivery device to prevent shifting or movement of the stent during delivery of the stent to a desired location within the bodily lumen. In at least one embodiment, the loading basket has a proximal end, a distal end, and a braided surface. The loading basket comprises a proximal end portion, a proximal transition portion, a body portion, a distal transition portion, a distal end portion, and an angled inward distal end. When loaded onto the delivery device, the outer surface of the stent contacts at least the angled inward distal end of the delivery device and movement of the stent is prevented.

Abstract: A handheld device in an audio and video system including a system for receiving and processing video and/or audio signals, a system for displaying a virtual image to a user, and a system for producing sounds audible to a user. The handheld device also incorporates a shroud to block ambient light when the handheld unit is engaged with the user's face. As a result, the user may hear sounds produced from the received audio signals. Further the user may see the virtual images produced from the received video signals when the handheld device is engaged with the users face.

Abstract: A video/audio system includes an interface device that receives a plurality of audio and video signals from a plurality of sources. The interface device combines these signals into various combinations and transmits the combinations to a receiver. The receiver is configured to interface one of the combinations of signals with a user. In this regard, the receiver allows the user to select one of the combinations, and in response, the receiver separates the video signal(s) of the selected combination from the audio signal(s) of the selected combination. Then, the receiver renders the video signal(s) via a display device and produces a sound defined by the audio signal(s) via a speaker. Accordingly, the user is able to control which set of audio and video signals are interfaced with the user.

Abstract: The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The lipid particles comprise a cationic lipid, a non-cationic lipid, and an mRNA molecule that is encapsulated within the lipid particle. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provides cationic lipids that are useful for preparing the compositions of the invention.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.

Abstract: Exercise apparatus can include first, second, third and fourth elongated frame members each defining a first, second, third, and fourth frame portion each comprising interior and exterior perimeters. The first frame member can include first, second, third, and fourth segments. The first frame portion can encompass first and second open interior regions. The third frame member can adjoin the first frame member at first and second points on the first frame member and span from the first point to the second point. The fourth frame member can adjoin the first frame member at spaced third and fourth points on the first frame member and span from the third point to the fourth point.

Abstract: A compound which is a compound of formula (I) or any salt thereof: wherein R1 is a Ci-C6 alkyl group, R2 is H or a Ci-C6 alkyl group, R3 is H or a Ci-C6 alkyl group, and n is an integer from 0 to 5.

Abstract: A handheld device in an audio and video system including a system for receiving and processing video and/or audio signals, a system for displaying a virtual image to a user, and a system for producing sounds audible to a user. The handheld device also incorporates a shroud to block ambient light when the handheld unit is engaged with the user's face. As a result, the user may hear sounds produced from the received audio signals. Further the user may see the virtual images produced from the received video signals when the handheld device is engaged with the users face.

Abstract: A fastener system for composite structure providing electromagnetic energy (EME) protection incorporates a fastener having a head with an engagement surface and a shank having a threaded end. A nut is received on the threaded end of the fastener, with the nut also having an engagement surface. At least one of the head engagement surface and the nut engagement surface incorporates a reduced area portion for engagement of a first mating surface or second mating surface, respectively.

Abstract: The application discloses integrated air suspension and platform lifting systems that utilize an existing air supply for lifting one or more platforms installed in a trailer or hauling vehicle. An apparatus for lifting a rear gate or platform of a trailer or a hauling vehicle is disclosed that includes an actuating mechanism operable to pivot the platform between a lowered position (e.g., where the end of the platform is in contact with the ground) and a range of raised positions (e.g., where the platform is raised to meet an elevated platform such as a loading dock). The lifting mechanisms for raising and lowering the platform(s) may utilize a pressurized gas supply from a compressor. In some embodiments, the lifting mechanism may be supplied with pressurized air from a compressor of a brake system of a tractor. In some embodiments a separate locking mechanism is provided to hold the platform in place after the lifting system has moved it into a desired position.

Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Abstract: A mandrel for manufacturing a stent from a single wire includes a cylindrical member having a plurality of pins at a proximal end region, a plurality of pins at a distal end region, and a plurality of indentations between the proximal pins and the distal pins. These indentations form a helical pattern on the outer surface of the cylindrical member. The single wire is wrapped around every proximal pin and distal pin on the mandrel by following the indentations in the mandrel. The single wire is slid through the indentation under any crossing section of wire and over the next crossing section of wire in an under-over pattern.

Abstract: Endoscopes and methods for making and using endoscopes. An example endoscope includes a handle portion and a shaft portion. The shaft portion may include one or more channels. A catheter and/or wire locking member may be coupled to a channel.

Abstract: A joint fastening system employs a lock bolt having a pull stem and locking threads inserted through a bore in a joint having fay sealant between layers. A collar is received over the pull stem to engage the threads, the collar producing tension on the threads to generate clamp force sufficient for fay sealant squeeze out.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract: Embodiments of the disclosure include devices and systems for using an end effector. In an embodiment, a medical device may include an articulation section. The articulation section may be operatively associated with an elongate articulation member configured to move the articulation section, wherein the articulation section can be configured to receive part of a conductive member. The medical device may also include an end effector. The end effector may include an electrode and a non-conductive section encasing a junction between the electrode and the conductive member, wherein the non-conductive section can be moveably coupled to the articulation section and can be fixedly coupled to the elongate articulation member.