Abstract: A pump subsystem for fluid delivery (e.g., in a wearable patch pump) is provided wherein pumping action is generated by linear piston movement that pulls a plug, which is interconnected to the piston between two mechanical extremes or end stops in a telescopic or variable volume fluid chamber. Such interconnection enables piston and plug to move a certain distance with respect to each other that corresponds to a predefined swept volume of the pump subsystem. Telescoping-like effect of relative piston and plug movement provides for intake and discharge of fluid with respect to the fluid chamber. Movement of plug within piston can be enabled by the friction of seals placed on the plug, which serve to provide resistance to piston motion and therefore force translation motion of the plug to lag relative to the piston translation motion during portions of the pump cycle.

Abstract: Pump subsystem for fluid delivery (e.g., in a wearable patch pump) comprises a fluid chamber with pumping motion and a valve shaft assembly with valving motion, both being driven by the same drive mechanism. Fluid chamber has variable volume chamber provided by a piston driven by the drive mechanism and translated relative to a plug in the pump housing. Piston extends the fluid chamber during an intake stroke and retracts the fluid chamber during a discharge stroke. Valve assembly has at least one valve shaft controllably translated by the drive mechanism to selectively align a first throughway with an opening in the pump chamber and a fluid intake port for an intake stroke to draw fluid into the fluid chamber, and align a second throughway with the opening in the pump hamber and a fluid discharge port for an discharge stroke to discharge fluid from the fluid chamber.

Abstract: The present disclosure relates to systems and methods for providing cybersecurity functionality to computer implemented inventions such as Internet of Thing (IoT) systems and object devices, and more specifically, to an improved cybersecurity system, method and capabilities for the protecting IoT and similar devices through non-discriminatory vendor/supplier independent distribution of secure predetermined IoT syndication data to unidentified and non-registered IoT devices, through the use of a passive data distribution technology and out-of-band, system-to-device distribution channel and no peer-to-peer stateless relationship with the receiving device and using Quality of Service (QoS) and enabling the determination as to whether there is any suspicious activity occurring and prohibiting the IoT device from taking any customer-defined action without have a separately provided authentication.

Abstract: Provided herein are certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to treat certain diseases, such as liver fibrosis, e.g., in the setting of NASH or ASH.

Abstract: This invention is directed to a medical device having an elongate shaft having a distal end and a controller coupled to the shaft. A control member can extend through at least part of the elongate shaft and at least part of the controller, wherein the control member in a tensioned configuration can be moveable by the controller to control the distal end of the shaft and the control member can be slack in an untensioned configuration. A tensioning mechanism can be configured to move relative to at least one of the elongate shaft and the controller to tension the control member and automatically lock the control member in the tensioned configuration.

Abstract: An apparatus and related methods for constructing articles with cured pressure-sensitive adhesives comprising (i) a coater that applies a curable adhesive to a membrane; (ii) a cross-linking apparatus adapted to receive said membrane with said curable adhesive, said cross-linking apparatus comprising a light source positioned a first predetermined height above an aperture plate having an aperture therethrough, wherein said aperture plate is positioned a second predetermined height, said first predetermined height and said second predetermined height selected to define an exposure area of light emitted from said light source on to said curable adhesive to form a composite product; and (iii) a roll adapted to receive said composite product, said roll adapted to control a speed at which said membrane with said curable adhesive is exposed to light from said light source.

Abstract: Provided herein are certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. He conjugates are useful to treat certain diseases, such as acromegaly.

Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Abstract: An apparatus and related methods for constructing articles with cured pressure-sensitive adhesives comprising (i) a coater that applies a curable adhesive to a membrane; (ii) a cross-linking apparatus adapted to receive said membrane with said curable adhesive, said cross-linking apparatus comprising a light source positioned a first predetermined height above an aperture plate having an aperture therethrough, wherein said aperture plate is positioned a second predetermined height, said first predetermined height and said second predetermined height selected to define an exposure area of light emitted from said light source on to said curable adhesive to form a composite product; and (iii) a roll adapted to receive said composite product, said roll adapted to control a speed at which said membrane with said curable adhesive is exposed to light from said light source.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.

Abstract: A collapsible protective helmet (10) comprises an impact-resistant base body (11) intended to encircle the head of a wearer and an impact-resistant crown (12) coupled to the base body by coupling means to be movable between a protective position in which the crown is supported by the base body in an orientation in which the crown covers the top of the head of the wearer and a stored position inverted relative to the protective position in which the crown is supported by, but nested in, the base body. The helmet further comprises releasable locking means for locking the base body (11) and crown (12) together in each of the two positions of the crown.

Abstract: An apparatus (200) and method for preparing a cylindrical object having a protective surface coating, such as a necked can (100), for decorating thereon using a printing technique. According to the method, a primer is applied onto the surface coating, and the primer is then dried to form a surface for decorating the object. The apparatus comprises a priming station (260) for applying a primer onto said surface coating, and a drying station (270) for drying the primer.

Abstract: The present disclosure provides an apparatus for handling objects. The apparatus comprises a carrying device (104) that is configured to move along a track (102). A handling device (224) is adapted to hold an object (108) and is mounted to the carrying device (104) such that it is rotatable with respect to the carrying device about a handling axis (226). A drive device (310) is disposed at a position along the track (102) and configured to produce a torque around a drive axis. The carrying device (104) can be moved along the track (102) in a direction perpendicular to the drive axis into and out of a drive position. In the drive position, the handling axis (226) of the handling device (224) is in substantial alignment with the drive axis of the drive device (310) whereupon the drive device induces a torque in the handling device (224) causing the handling device to rotate, thereby causing the object (108) held by the handling device to rotate.

Abstract: The invention provides an antifungal composition comprising an antifungal compound of formula R—S+(R?)2 or R—N+(R?)3 wherein R is C17-C32 straight chain or branched alkyl; and each R? is independently methyl, ethyl, propyl, isopropyl or butyl; and uses of said composition as antifungal agents.

Abstract: Certain embodiments of the invention provide a cationic lipid of formula (I): wherein R1, R2, R3 and R4 are defined as described herein, as well as methods of making these lipids. Certain embodiments of the invention also provide nucleic acid-lipid particles comprising a cationic lipid of formula (I), methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.

Abstract: A printing system for printing on an outer surface of a tubular object is provided. The printing system comprises at least one printing station for printing on the outer surface of the tubular object (100); and at least one holding device for holding the tubular object during a printing process. The holding device comprises: a substantially annular gripper ring (200) adapted to be partially inserted into a tubular object. The gripper ring comprises a radially compressible portion (201) configured to securely engage with an inner surface of the tubular object. The radially compressible portion exerts a radially outward mechanical restoring force when compressed.

Abstract: A system for transmitting rotational motion between a driving element and a driven element comprises a driving element that is coupled to a torque input that causes the driving element to rotate about a drive axis. The driving element comprises a first magnetic element. A driven element is configured to rotate about a driven axis. The driven element comprises a second magnetic element. Both the first magnetic element and second magnetic element are susceptible to a magnetic field, and at least one of the first and second magnetic element produces a magnetic field. A magnetic interaction between the first magnetic element and the second magnetic element couples the rotational motion of the driving element and the rotational motion of the driven element. The driving and driven elements are coupled at a predetermined rotational orientation with respect to each other.

Abstract: The invention provides PEG-conjugated lipids of formula (I): A-B-C (I) wherein A, B, and C have any of the values defined in the specification, as well as compositions comprising the PEG-conjugated lipids of formula (I), nucleic acid lipid nanoparticles comprising the PEG-conjugated lipids of formula (I), and methods of using the PEG-conjugated lipids of formula (I), the compositions, and the nucleic acid nanoparticles.

Abstract: A device assembly having a syndicated data service interface that is communicatively coupled to a vendor-specific syndicated data application platform and having an installed vendor specific syndicated data application, with the interface receiving point-to-multipoint non-addressed transport bearer channels of different syndicated data channel transport networks initially only including the monitoring of the syndicated data channels and not decoding the syndicated data messages or syndicated data informational data contained therein, identifying from the transport bearer channels a received syndicated data channel having an syndicated data channel identifier of the specific syndicated data device, and reading the syndicated data messages within the received syndicated data channel and extracting the syndicated data supplier-independent informational data from the syndicated data message and providing the extracted syndicated data informational data to at least one of the installed vendor specific syndicated d

Abstract: The invention provides conjugates that comprise a bivalent targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates, compositions comprising the bidentate targeting ligands and the conjugates, as well as methods for targeting therapeutic nucleic acids with the bidentate conjugates. The conjugates are useful to target therapeutic nucleic acids.