Patents by Inventor Mark Aaron Emalfarb
Mark Aaron Emalfarb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11981889Abstract: The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica, capable of producing elevated amounts of nicotinamide riboside.Type: GrantFiled: October 25, 2022Date of Patent: May 14, 2024Assignee: Dyadic International (USA), Inc.Inventors: Mark Aaron Emalfarb, Ronen Tchelet, Kari Tapio Koivuranta, Marja Hannele Ilmén, Sandra Castillo, Paula Jouhten
-
Publication number: 20230313121Abstract: The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica, having reduced activity or expression of KEX2 and/or ALP7, said filamentous fungi is capable of producing elevated amounts and stability of an exogenous protein.Type: ApplicationFiled: May 13, 2021Publication date: October 5, 2023Inventors: Marika Vitikainen, Anne Huuskonen, Andriy Kovalchuk, Christopher Landowski, Ronen Tchelet, Mark Aaron Emalfarb, Markku Saloheimo
-
Publication number: 20230183638Abstract: The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica, capable of producing elevated amounts of nicotinamide riboside.Type: ApplicationFiled: October 25, 2022Publication date: June 15, 2023Inventors: Mark Aaron Emalfarb, Ronan Tchelet, Kari Tapio Koivuranta, Marja Hannele Ilmén, Sandra Castillo, Paula Jouhten
-
Publication number: 20220106616Abstract: The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica capable of producing cannabinoids and precursors thereof, particularly of producing cannabigerolic acid (CBGA) and/or cannabigerovarinic acid (CBGVA) and products thereof, including tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabidivarinic acid (CBDVA), and use thereof for producing said precursors and cannabinoids.Type: ApplicationFiled: February 10, 2020Publication date: April 7, 2022Inventors: Mark Aaron EMALFARB, Ronen TCHELET, Gabor KERESZTES, Marja Hannele ILMEN, Outi Mirjami KOIVISTOINEN, Kari Tapio KOIVURANTA, Paula JOUHTEN, Sandra CASTILLO
-
Patent number: 8871493Abstract: A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.Type: GrantFiled: September 17, 2012Date of Patent: October 28, 2014Assignee: Dyadic International (USA), Inc.Inventors: Mark Aaron Emalfarb, Richard Paul Burlingame, Philip Terry Olson, Arkady Panteleimonovich Sinitsyn, Martine Parriche, Jean Christophe Bousson, Christine Marie Pynnonen, Peter Jan Punt, Cornelia Marie Johanna Van Zeijl
-
Publication number: 20140127788Abstract: A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.Type: ApplicationFiled: September 17, 2012Publication date: May 8, 2014Inventors: Mark Aaron Emalfarb, Richard Paul Burlingame, Philip Terry Olson, Arkady Panteleimonovich Sinitsyn, Martine Parriche, Jean Christophe Bousson, Christine Marie Pynnonen, Peter Jan Punt, Cornelia Maria Johanna Van Zeijl
-
Publication number: 20130143271Abstract: The invention pertains to novel proteins corresponding to Chrysosporium glycosyl hydrolases of families 7 and 10, exhibiting a minimum aminoacid identity of 70 and 75%, respectively, with the amino acid sequence of SEQ ID No's 2 and 4, and to a protein corresponding to a Chrysosporium glyceraldehyde phosphate dehydrogenase, exhibiting at least 86% amino acid identity with the partial amino acid sequence of SEQ ID No. 6. The invention further relates to nucleic acid sequences encoding these proteins, and especially to promoter sequences regulating the expression of the corresponding genes. The preferred host for expressing these genes is a fungus, especially a Chrysosporium strain.Type: ApplicationFiled: March 14, 2011Publication date: June 6, 2013Inventors: Mark Aaron Emalfarb, Peter Jan Punt, Cornelia Maria Johanna Van Zeijl
-
Patent number: 8268585Abstract: A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.Type: GrantFiled: March 13, 2008Date of Patent: September 18, 2012Assignee: Dyadic International (USA), Inc.Inventors: Mark Aaron Emalfarb, Richard Paul Burlingame, Philip Terry Olson, Arkady Panteleimonovich Sinitsyn, Martine Parriche, Jean Christophe Bousson, Christine Marie Pynnonen, Peter Jan Punt, Cornelia Maria Johanna Van Zeijl
-
Publication number: 20110237485Abstract: The subject invention relates to novel compositions of neutral and/or alkaline cellulase and methods for obtaining neutral and/or alkaline cellulase compositions from Chrysosporium cultures, in particular Chrysosporium lucknowense. This invention also provides mutants and methods of generating mutants of Chrysosporium capable of producing neutral and/or alkaline cellulase. This invention also relates to the genes encoding the enzymes comprising the neutral and/or alkaline cellulase composition. In addition, this invention provides methods of culturing Chrysosporium to produce neutral and/or alkaline cellulases. The neutral and/or alkaline cellulase compositions of the subject invention can be used in a variety of processes including stone washing of clothing, detergent processes, deinking, color brightening, depilling and biobleaching of paper and pulp and treatment of waste streams.Type: ApplicationFiled: February 21, 2011Publication date: September 29, 2011Inventors: Mark Aaron Emalfarb, Irina Vladimirovna Solovjeva, Arie Ben-Bassat, Richard P. Burlingame, Vladimir Mikhaylovich Chernoglazov, Oleg Nicolaevich Ocounev, Philip T. Olson, Arkady Panteleimonovich Sinitsyn
-
Patent number: 7906309Abstract: The invention pertains to novel proteins corresponding to Chrysosporium glycosyl hydrolases of families 7 and 10, exhibiting a minimum aminoacid identity of 70 and 75%, respectively, with the amino acid sequence of SEQ ID No's 2 and 4, and to a protein corresponding to a Chrysosporium glyceraldehyde phosphate dehydrogenase, exhibiting at least 86% amino acid identity with the partial amino acid sequence of SEQ ID No. 6. The invention further relates to nucleic acid sequences encoding these proteins, and especially to promoter sequences regulating the expression of the corresponding genes. The preferred host for expressing these genes is a fungus, especially a Chrysosporium strain.Type: GrantFiled: April 17, 2001Date of Patent: March 15, 2011Assignee: Dyadic International (USA), Inc.Inventors: Mark Aaron Emalfarb, Peter Jan Punt, Cornelia Maria Johanna Van Zeijl
-
Patent number: 7892812Abstract: A computer-based method and apparatus for the analysis specification and support of work processes. The system is designed to support multiple interdependent decisions, at least some of which require collaboration among multiple participants (116). Work processes are modeled using an application framework (99) used to develop abstract, decision (100) process models. The decision (100) process models are used as a pattern to instantiate concrete process models that incorporate the work defined by the abstract process. The process model is then used to instantiate project models that incorporate the required work from the process. The project models are used to direct and guide the behavior of the participants (116) in the work process.Type: GrantFiled: September 30, 1997Date of Patent: February 22, 2011Assignee: Dyadic International (USA), Inc.Inventors: Mark Aaron Emalfarb, Irina Vladimirovna Solovjeva, Arie Ben-Bassat, Richard P. Burlingame, Vladimir Mikhaylovich Chernoglazov, Oleg Nicolaevich Ocounev, Philip T. Olson, Arkady Panteleimonovich Sinitsyn
-
Publication number: 20080194005Abstract: A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.Type: ApplicationFiled: March 13, 2008Publication date: August 14, 2008Inventors: Mark Aaron EMALFARB, Richard Paul Burlingame, Philip Terry Olson, Arkady Panteleimonovich Sinitsyn, Martine Parriche, Jean Christophe Bousson, Christine Marie Pynnonen, Peter Jan Punt, Cornelia Maria Johanna Van Zeijl
-
Patent number: 7399627Abstract: A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.Type: GrantFiled: March 21, 2003Date of Patent: July 15, 2008Assignee: Dyadic International (USA), Inc.Inventors: Mark Aaron Emalfarb, Richard Paul Burlingame, Philip Terry Olson, Arkady Panteleimonovich Sinitsyn, Martine Parriche, Jean Christophe Bousson, Christine Marie Pynnonen, Peter Jan Punt, Cornelia Marie Johanna Van Zeijl
-
Publication number: 20040002136Abstract: A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.Type: ApplicationFiled: March 21, 2003Publication date: January 1, 2004Inventors: Mark Aaron Emalfarb, Richard Paul Burlingame, Philip Terry Olson, Arkady Panteleimonovich Sinitsyn, Martine Parriche, Jean Christophe Bousson, Christine Marie Pynnonen, Peter Jan Punt, Cornelia Maria Johanna Van Zeijl
-
Publication number: 20030187243Abstract: The invention pertains to novel proteins corresponding to Chrysosporium glycosyl hydrolases of families 7 and 10, exhibiting a minimum aminoacid identity of 70 and 75%, respectively, with the amino acid sequence of SEQ ID No's 2 and 4, and to a protein corresponding to a Chrysosporium glyceraldehyde phosphate dehydrogenase, exhibiting at least 86% amino acid identity with the partial amino acid sequence of SEQ ID No. 6. The invention further relates to nucleic acid sequences encoding these proteins, and especially to promoter sequences regulating the expression of the corresponding genes. The preferred host for expressing these genes is a fungus, especially a Chrysosporium strain.Type: ApplicationFiled: April 11, 2003Publication date: October 2, 2003Inventors: Mark Aaron Emalfarb, Peter Jan Punt, Cornelia Maria Johanna Van Zeijl
-
Publication number: 20030157595Abstract: A computer-based method and apparatus for the analysis specification and support of work processes. The system is designed to support multiple interdependent decisions, at least some of which require collaboration among multiple participants (116). Work processes are modeled using an application framework (99) used to develop abstract, decision (100) process models. The decision (100) process models are used as a pattern to instantiate concrete process models that incorporate the work defined by the abstract process. The process model is then used to instantiate project models that incorporate the required work from the process. The project models are used to direct and guide the behavior of the participants (116) in the work process.Type: ApplicationFiled: June 3, 1999Publication date: August 21, 2003Inventors: MARK AARON EMALFARB, IRINA VLADIMIROVNA SOLOVJEVA, ARIE BEN-BASSAT, RICHARD P. BURLINGAME, VLADIMIR MIKHAYLOVICH CHERNOGLAZOV, OLEG NICOLAEVICH OCOUNEV, PHILIP T. OLSON, ARKADY PANTELEIMONOVICH SINITSYN
-
Patent number: 6015707Abstract: The subject invention relates to novel compositions of neutral and/or alkaline cellulase and methods for obtaining neutral and/or alkaline cellulase compositions from Chrysosporium cultures, in particular Chrysosporium lucknowense. This invention also provides mutants and methods of generating mutants of Chrysosporium capable of producing neutral and/or alkaline cellulase. This invention also relates to the genes encoding the enzymes comprising the neutral and/or alkaline cellulase composition. In addition, this invention provides methods of culturing Chrysosporium to produce neutral and/or alkaline cellulases. The neutral and/or alkaline cellulase compositions of the subject invention can be used in a variety of processes including stone washing of clothing, detergent processes, deinking and biobleaching of paper & pulp and treatment of waste streams.Type: GrantFiled: June 29, 1998Date of Patent: January 18, 2000Assignee: Mark A. EmalfarbInventors: Mark Aaron Emalfarb, Arie Ben-Bassat, Arkady Panteleimonovich Sinitsyn
-
Patent number: 5811381Abstract: The subject invention relates to novel compositions of neutral and/or alkaline cellulase and methods for obtaining neutral and/or alkaline cellulase compositions from Chrysosporium cultures, in particular Chrysosporium lucknowense. This invention also provides mutants and methods of generating mutants of Chrysosporium capable of producing neutral and/or alkaline cellulose. This invention also relates to the genes encoding the enzymes comprising the neutral and/or alkaline cellulase composition. In addition, this invention provides methods of culturing Chrysosporium to produce neutral and/or alkaline cellulases. The neutral and/or alkaline cellulase compositions of the subject invention can be used in a variety of processes including stone washing of clothing, detergent processes, deinking and biobleaching of paper & pulp and treatment of waste streams.Type: GrantFiled: October 10, 1996Date of Patent: September 22, 1998Assignee: Mark A. EmalfarbInventors: Mark Aaron Emalfarb, Arie Ben-Bassat, Richard P. Burlingame, Vladimir Mikhaylovich Chernoglazov, Oleg Nicolaevich Okounev, Philip T. Olson, Arkady Panteleimonovich Sinitsyn, Irina Vladimirovna Solovjeva