Patents by Inventor Mark Alan Breidenbach

Mark Alan Breidenbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
    Patent number: 10183998
    Abstract: The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: January 22, 2019
    Assignee: Redwood Bioscience, Inc.
    Inventors: Robyn M. Barfield, Mark Alan Breidenbach, Gregory W. deHart, David Rabuka
  • Aldehyde-tagged protein-based drug carriers and methods of use
    Patent number: 9879249
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: January 30, 2018
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Mark Alan Breidenbach
  • Aldehyde-Tagged Immunoglobulin Polypeptides and Methods of Use Thereof
    Publication number: 20170166639
    Abstract: The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
    Type: Application
    Filed: November 28, 2016
    Publication date: June 15, 2017
    Inventors: Robyn M. Barfield, Mark Alan Breidenbach, Gregory W. deHart, David Rabuka
  • Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
    Patent number: 9540438
    Abstract: The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: January 10, 2017
    Assignee: Redwood Bioscience, Inc.
    Inventors: Robyn M. Barfield, Mark Alan Breidenbach, Gregory W. deHart, David Rabuka
  • Aldehyde-Tagged Protein-Based Drug Carriers and Methods of Use
    Publication number: 20160160206
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Application
    Filed: December 4, 2015
    Publication date: June 9, 2016
    Inventors: David Rabuka, Mark Alan Breidenbach
  • Aldehyde-tagged protein-based drug carriers and methods of use
    Patent number: 9238878
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: January 19, 2016
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Mark Alan Breidenbach
  • Aldehyde-Tagged Immunoglobulin Polypeptides and Methods of Use Thereof
    Publication number: 20120183566
    Abstract: The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
    Type: Application
    Filed: January 13, 2012
    Publication date: July 19, 2012
    Inventors: Robyn M. Barfield, Mark Alan Breidenbach, Gregory W. deHart, David Rabuka
  • Aldehyde-Tagged Protein-Based Drug Carriers and Methods of Use
    Publication number: 20100210543
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Application
    Filed: February 16, 2010
    Publication date: August 19, 2010
    Inventors: David Rabuka, Mark Alan Breidenbach