Patents by Inventor Mark Andrew Fleming

Mark Andrew Fleming has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220046872
    Abstract: A stackable modular planter includes an open top plant box with a base and four side walls adapted to receive a growing medium and plants. The open top plant box has a first width. An irrigation box below the open top plant box base has a second width larger than the first width. The irrigation box can be filled with irrigation fluid. An open top hopper on one side of the open top plant box on top of the irrigation box can receive irrigation fluid which drains into the irrigation box. An overflow drain aperture in the irrigation box lets excess irrigation fluid flow. When a plurality of the stackable modular planters are stacked above another planter, excess irrigation can flow from the overflow aperture into the hopper of the planter below.
    Type: Application
    Filed: February 7, 2020
    Publication date: February 17, 2022
    Inventors: Richard Alexander Sabin, Mark Andrew Fleming
  • Publication number: 20140308242
    Abstract: The invention relates to biomarkers measurable in a human subject that have prognostic value with respect to efficacy of therapeutic treatments for Hepatitis C viral infection. The markers also are believed to have value for diagnosis liver health/liver damage.
    Type: Application
    Filed: October 21, 2011
    Publication date: October 16, 2014
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Mark Andrew Fleming, Brain J. Hare, Daniel Chelsky, Rene Allard, Eustache Paramithiotis
  • Patent number: 7527952
    Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: May 5, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Keith P. Wilson, Michael D. Sintchak, Mark Andrew Fleming, David M. Armistead
  • Patent number: 7216041
    Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: May 8, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Keith P. Wilson, Michael D. Sintchak, Mark Andrew Fleming, David M. Armistead
  • Patent number: 7065452
    Abstract: The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: June 20, 2006
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David M. Armistead, Matthew James Fitzgibbon, Mark Andrew Fleming, James P. Griffith, Eunice E. Kim, Joseph L. Kim, Michael D. Sintchak, John Allan Thomson, Keith P. Wilson
  • Patent number: 6128582
    Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: October 3, 2000
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Keith P. Wilson, Michael D. Sintchak, Mark Andrew Fleming, David M. Armistead
  • Patent number: 5978740
    Abstract: The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
    Type: Grant
    Filed: August 9, 1995
    Date of Patent: November 2, 1999
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David M. Armistead, Matthew James Fitzgibbon, Mark Andrew Fleming, James P. Griffith, Eunice E. Kim, Joseph L. Kim, Michael D. Sintchak, John Allan Thomson, Keith P. Wilson