Abstract: The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.

Abstract: Systems and methods are provided for secure messaging with constrained user actions. An example method includes causing presentation of an interactive user interface, the interactive user interface enabling messaging with end users, each end user being associated with a respective phone number. Selection of a particular end user is received via the interaction user interface and the interactive user interface is updated to include a selectable option which triggers transmission of a standardized consent message to a particular phone number associated with the particular end user. User input is received which indicates receipt of externally provided affirmative consent. The interactive user interface is updated, with the updated interactive user interface including an input portion configured to receive arbitrary information for transmission to the particular phone number.

Abstract: The present disclosure generally provides nutritional compositions that are useful for promoting beneficial bacteria in the gastrointestinal tract of a Cesarean-section (C-section)-delivered infant. The nutritional composition can include a prebiotic composition comprising human milk oligosaccharides (HMO), milk fat globule membrane (MFGM), and galacto-oligosaccharides (GOS) and/or polydextrose (PDX). The present disclosure also provides methods for promoting the growth of beneficial microbiota in the gastrointestinal tract of C-section-delivered infants comprising administering to a C-section-delivered infant the disclosed nutritional composition.

Abstract: The present disclosure generally relates to pediatric nutritional compositions including galacto-oligosaccharide and human milk oligosaccharide or a precursor thereof. Further, the nutritional compositions may include GOS in combination with a first human milk oligosaccharide or precursor thereof and a second human milk oligosaccharide or precursor thereof. The disclosed nutritional compositions advantageously modify gut microbiome and improve select markers of immunity, brain structure, and gut function.

Abstract: An implantable device for treating disc degenerative disease and arthritis of the spine. The implant is sized for placement into an intravertebral disc space. The implant has a body with a predetermined, defined, repeating, three-dimensional pattern at least partially on at least one of its surfaces. The pattern is adapted to create a surface area of bone-contacting features that enhance in-growth and biological attachment to a biocompatible material. Also disclosed are process steps for making the implant.

Abstract: An implantable device for treating disc degenerative disease and arthritis of the spine. The implant is sized for placement into an intravertebral disc space. The implant has a body with a predetermined, defined, repeating, three-dimensional pattern at least partially on at least one of its surfaces. The pattern is adapted to create a surface area of bone-contacting features that enhance in-growth and biological attachment to a biocompatible material. Also disclosed are process steps for making the implant.

Abstract: Disclosed is a printed circuit board (PCB) layout for increasing the ability of the PCB to transfer heat away from a component mounted thereon. The locations of signal vias in the PCB are selected so as to define continuous pathways in a PCB heat sink layer. This allows heat to be effectively conducted away from thermal vias connected to heat sink layer, thereby preventing PCB-mounted components from overheating.

Abstract: A method and apparatus for testing the seal between a container and a flexible lid by measuring the lid's deflection. In the disclosed embodiment, an actuator impacts the lid and activates an alarm if the lid is not securely attached to the container.

Abstract: A method and apparatus for transferring products from one conveyor to another. Guide rails direct products into substantial contact with a push bar. The push bar pushes the products from one conveyor belt to another conveyor belt in a smooth and efficient manner, thereby significantly reducing the possibility of damaging the products.