Patents by Inventor Mark Boldin

Mark Boldin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of the function of fas receptors and other proteins
    Publication number: 20070154905
    Abstract: The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors that interfere with the proteolytic activity of MORT-1-binding proteins having proteolytic activity are provided, as well as a method of designing them.
    Type: Application
    Filed: September 18, 2006
    Publication date: July 5, 2007
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldin, Tanya Goncharov, Yury Golstev
  • Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors
    Patent number: 7186682
    Abstract: The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the FAS-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the FAS-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric FAS-Rs and oligomeric receptors having a mixture of TNF-Rs and FAS-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: March 6, 2007
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldin, Igor Mett, Eugene Varfolomeev
  • Modulators of the function of FAS/AP01 receptors
    Patent number: 7108999
    Abstract: Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: September 19, 2006
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldin, Eugene Varfolomeev, Igor Mett
  • Modulators of intracellular inflammation, cell death and cell survival pathways
    Publication number: 20050288225
    Abstract: A B1 protein, its isoforms, analogs, fragments and derivatives, are provided. The protein is useful in the modulation of intracellular inflammation, cell death and/or cell survival pathways.
    Type: Application
    Filed: May 17, 2005
    Publication date: December 29, 2005
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Mark Boldin, Nikolai Malinin
  • Modulators of the function of FAS/AP01 receptors
    Publication number: 20050013816
    Abstract: Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.
    Type: Application
    Filed: August 23, 2004
    Publication date: January 20, 2005
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldin, Eugene Varfolomeev, Igor Mett
  • Modulators of the function of FAS/APO1 receptors
    Patent number: 6808891
    Abstract: Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: October 26, 2004
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Mark Boldin, Eugene Varfolomeev, Igor Mett
  • Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors
    Publication number: 20040013646
    Abstract: The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the FAS-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the FAS-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric FAS-Rs and oligomeric receptors having a mixture of TNF-Rs and FAS-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.
    Type: Application
    Filed: January 24, 2003
    Publication date: January 22, 2004
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldin, Igor Mett, Eugene Varfolomeev
  • Modulators of the function of FAS receptors and other proteins
    Publication number: 20030219411
    Abstract: The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors that interfere with the proteolytic activity of MORT-1-binding proteins having proteolytic activity are provided, as well as a method of designing them.
    Type: Application
    Filed: February 20, 2003
    Publication date: November 27, 2003
    Applicant: Yeda Research and Development Co., LTD
    Inventors: David Wallach, Mark Boldin, Tanya Goncharov, Yury V. Golstev
  • Modulators of the function of FAS receptors and other proteins
    Patent number: 6586571
    Abstract: The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors which interfere with the proteolytic activity of MORT-1-biding proteins having proteolytic activity are provided as well as a method of designing them.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: July 1, 2003
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldin, Tanya Goncharov, Yury V. Golstev
  • Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors
    Patent number: 6579697
    Abstract: The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the FAS-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the FAS-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric FAS-Rs and oligomeric receptors having a mixture of TNF-Rs and FAS-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: June 17, 2003
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldin, Igor Mett, Eugene Varfolomeev
  • Modulators of the function of FAS/APO1 receptors
    Publication number: 20020082401
    Abstract: The MORT-1 protein, analogs thereof and fragments thereof bind with the intracellular domain of the FAS ligand receptor. DNA encoding such protein, analogs and fragments, may be used to make vectors and host cells in order to produce such proteins, analogs and fragments. The peptides may be formulated into pharmaceutical compositions for use in modulation of the FAS-R ligand effect on cells carrying a FAS-R.
    Type: Application
    Filed: April 3, 2001
    Publication date: June 27, 2002
    Applicant: Yeda Research and Development Company
    Inventors: David Wallach, Mark Boldin, Eugene Varfolomeev, Igor Mett
  • Modulators of the function of FAS receptors and other proteins
    Patent number: 6399327
    Abstract: The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors which interfere with the proteolytic activity of MORT-1-biding proteins having proteolytic activity are provided as well as a method of designing them.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: June 4, 2002
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldin, Tanya Goncharov, Yury V. Golstev
  • Modulators of the function of FAS/APO1 receptors
    Publication number: 20020058798
    Abstract: Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.
    Type: Application
    Filed: August 22, 2001
    Publication date: May 16, 2002
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldin, Eugene Varfolomeev, Igor Mett