Patents by Inventor Mark Bonyhadi

Mark Bonyhadi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6867041
    Abstract: The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and/or stimulate cells that maximizes stimulation and/or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: March 15, 2005
    Assignee: XCYTE Therapies, Inc.
    Inventors: Ronald Berenson, Che Law, Mark Bonyhadi, Narinder Saund, Stewart Craig, Alan Hardwick, Dale Kalamasz, David McMillen
  • Publication number: 20040241162
    Abstract: The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.
    Type: Application
    Filed: January 20, 2004
    Publication date: December 2, 2004
    Applicant: XCYTE Therapies, Inc.
    Inventors: Ronald J. Berenson, Che Law, Mark Bonyhadi, Narinder Saund, Stewart Craig, Alan Hardwick, Dale Kalamasz, David McMillen, Harjinder Singh Chana
  • Publication number: 20040224402
    Abstract: The present invention relates generally to methods for generating, expanding, and isolating antigen-specific T cells. Compositions of antigen-specific T cells activated and expanded by the methods herein are further provided.
    Type: Application
    Filed: December 19, 2003
    Publication date: November 11, 2004
    Applicant: XCYTE Therapies, Inc.
    Inventors: Mark Bonyhadi, Dale Kalamasz
  • Patent number: 6797514
    Abstract: The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and stimulate cells that maximizes stimulation and/or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: September 28, 2004
    Assignee: Xcyte Therapies, Inc.
    Inventors: Ronald Berenson, Che Law, Mark Bonyhadi, Narinder Saund, Stewart Craig, Alan Hardwick, Dale Kalamasz, David McMillen
  • Publication number: 20040175373
    Abstract: The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g. autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
    Type: Application
    Filed: December 5, 2003
    Publication date: September 9, 2004
    Applicant: XCYTE Therapies, Inc.
    Inventors: Ronald Berenson, Mark Bonyhadi, Dale Kalamasz
  • Publication number: 20040151704
    Abstract: The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g. autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
    Type: Application
    Filed: June 24, 2003
    Publication date: August 5, 2004
    Applicant: XCYTE Therapies, Inc.
    Inventors: Ronald Berenson, Mark Bonyhadi, Dale Kalamasz
  • Publication number: 20040005298
    Abstract: The present invention relates generally to methods for stimulating, activating, and maintaining or increasing the polyclonality of expressed TCRs in a population of T cells. In the various embodiments, cells are stimulated with a surface, wherein the surface has attached thereto one or more agents that ligate a cell surface moiety of at least a portion of the T cells and stimulates at least a portion of the T cells, yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement.
    Type: Application
    Filed: February 7, 2003
    Publication date: January 8, 2004
    Applicant: XCYTE Therapies, Inc.
    Inventors: Mark Bonyhadi, Ronald J. Berenson
  • Publication number: 20030235908
    Abstract: The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.
    Type: Application
    Filed: January 22, 2003
    Publication date: December 25, 2003
    Applicant: XCYTE Therapies, Inc.
    Inventors: Ronald Berenson, Che Law, Mark Bonyhadi, Narinder Saund, Stewart Craig, Alan Hardwick, Dale Kalamasz, David McMillen, Harjinder Singh Chana
  • Publication number: 20030124122
    Abstract: The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and/or stimulate cells that maximizes stimulation and/or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement.
    Type: Application
    Filed: April 26, 2002
    Publication date: July 3, 2003
    Applicant: XCYTE Therapies, Inc.
    Inventors: Ronald Berenson, Che Law, Mark Bonyhadi, Narinder Saund, Stewart Craig, Alan Hardwick, Dale Kalamasz, David McMillen
  • Publication number: 20030119185
    Abstract: The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.
    Type: Application
    Filed: June 28, 2002
    Publication date: June 26, 2003
    Applicant: XCYTE Therapies, Inc.
    Inventors: Ronald Berenson, Che Law, Mark Bonyhadi, Narinder Saund, Stewart Craig, Alan Hardwick, Dale Kalamasz, David McMillen, Harjinder Singh Chana
  • Publication number: 20030082806
    Abstract: The present invention relates to methods for maturing antigen-presenting cells, and more particularly, to methods for maturing dendritic cells. Methods for generating mature and/or maturing antigen-presenting cells in vitro and in vivo are disclosed. The present invention also relates to compositions of cells, including mature antigen-presenting cells and/or activated T cells and their use in generating immune responses in vivo, and inhibiting the development of or preventing infectious diseases and cancers.
    Type: Application
    Filed: April 29, 2002
    Publication date: May 1, 2003
    Applicant: XCYTE Therapies, Inc.
    Inventors: Ronald Jay Berenson, Mark Bonyhadi, Stewart Craig, Dale Kalamasz, Tatsue Monji
  • Publication number: 20030022210
    Abstract: The present invention relates to methods for the use of T cells or supernatants therefrom, and more particularly, activated T cells, in facilitating and/or regulating the differentiation, de-differentiation, maturation, organization, repair, and regeneration of various cells/tissues. Methods for inducing tissue repair and regeneration in vitro and in vivo are disclosed. The present invention also relates to compositions of cells, including activated T cells and/or cells resulting from the co-culture with activated T cells, and their use in inducing tissue repair and regeneration in vivo.
    Type: Application
    Filed: June 3, 2002
    Publication date: January 30, 2003
    Inventors: Mark Bonyhadi, Ron Berenson
  • Publication number: 20020119568
    Abstract: The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and stimulate cells that maximizes stimulation and/or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement.
    Type: Application
    Filed: September 20, 2001
    Publication date: August 29, 2002
    Inventors: Ronald Berenson, Che Law, Mark Bonyhadi, Narinder Saund, Stewart Craig, Alan Hardwick, Dale Kalamasz, David McMillen
  • Publication number: 20020058019
    Abstract: The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and stimulate cells that maximizes stimulation and/or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement.
    Type: Application
    Filed: February 26, 2001
    Publication date: May 16, 2002
    Inventors: Ronald Berenson, Che Law, Mark Bonyhadi, Narinder Saund, Stewart Craig, Alan Hardwick, Dale Kalamasz, David McMillen