Abstract: The present invention relates to genetically modified B cells and their uses thereof, for example, for the treatment of a variety of diseases and disorders, including cancer, heart disease, inflammatory disease, muscle wasting disease, neurological disease, and the like. In certain embodiments, the invention relates to an isolated modified B cell (“CAR-B cell), capable of expressing a chimeric receptor (“CAR-B receptor”), wherein said chimeric receptor comprises (a) an extracellular domain; (b) a transmembrane domain; and (c) a cytoplasmic domain that comprises at least one signaling domain. In various embodiments, the invention comprises an isolated modified B cell, wherein said B cell is capable of expressing and secreting a payload, wherein the payload is not naturally expressed in a B cell or is expressed at higher levels than is naturally expressed in a B cell. In various embodiments, the payload is an antibody or fragment thereof.

Abstract: An improved process for fabricating expanded thermoplastic polymers (eTP) starting from non-expanded TP is disclosed whereby said process has improved thermal control, uses preferably environmentally friendly foaming gasses, avoids anisotropy and sticking of the eTP during the processing and minimises the duration of the charging step.

Abstract: Systems, methods, and media for actions in distributed computing by receiving trigger event specification that defines a trigger event that will cause a notification to be transmitted. A determination is made whether the trigger event has occurred. Responsive to the determination that the trigger event has occurred, a notification is generated. Excess data is removed from the notification. The notification, with the excess data removed, is sent.

Abstract: Creating, executing, and managing flow plans by performing at least the following: presenting on a display an action instance associated with a flow plan within an action designer user interface, wherein the action designer user interface comprises: an action outline component that includes an input graphical element, one or more step instance graphical element, and an action graphical element, wherein one of the graphical elements is highlighted within the action outline component; and an action window adjacent to the action outline component, wherein the action window comprises one or more input fields that dynamically change based on a user selection of one of the graphical elements within the action outline component, and present a window to select from a list of pre-existing step instance types for a step instance.

Abstract: Systems, methods, and media for actions in distributed computing by receiving trigger event specification that defines a trigger event that will cause a notification to be transmitted. A determination is made whether the trigger event has occurred. Responsive to the determination that the trigger event has occurred, a notification is generated. Excess data is removed from the notification. The notification, with the excess data removed, is sent.

Abstract: Systems, methods, and media for actions in distributed computing by receiving trigger event specification that defines a trigger event that will cause a notification to be transmitted. A determination is made whether the trigger event has occurred. Responsive to the determination that the trigger event has occurred, a notification is generated. Excess data is removed from the notification. The notification, with the excess data removed, is sent.

Abstract: An improved process for fabricating expanded thermoplastic polymers (eTP) starting from non-expanded TP is disclosed whereby said process has improved thermal control, uses preferably environmentally friendly foaming gasses, avoids anisotropy and sticking of the eTP during the processing and minimises the duration of the charging step.

Abstract: Creating, executing, and managing flow plans by performing at least the following: presenting on a display an operational view of an executing flow plan within an operational view user interface that includes: a flow plan graphical outline associated with the executing flow plan, wherein the flow plan graphical outline comprises a trigger instance graphical element for a trigger instance, at least one action instance graphical element for at least one action instance, and at least one step instance graphical element for at least one step instance; one or more state indicators adjacent to the flow plan graphical outline that provide an overall state of the trigger instance, the action instance, and the step instance; and one or more metrics relating to executing the trigger instance, the action instance, and the step instance.

Abstract: Systems, methods, and media for actions in distributed computing by receiving trigger event specification that defines a trigger event that will cause a notification to be transmitted. A determination is made whether the trigger event has occurred. Responsive to the determination that the trigger event has occurred, a notification is generated. Excess data is removed from the notification. The notification, with the excess data removed, is sent.

Abstract: Creating, executing, and managing flow plans by performing at least the following: presenting on a display an action instance associated with a flow plan within an action designer user interface, wherein the action designer user interface comprises: an action outline component that includes an input graphical element, one or more step instance graphical element, and an action graphical element, wherein one of the graphical elements is highlighted within the action outline component; and an action window adjacent to the action outline component, wherein the action window comprises one or more input fields that dynamically change based on a user selection of one of the graphical elements within the action outline component, and present a window to select from a list of pre-existing step instance types for a step instance.

Abstract: Provided herein are genetic markers for predicting response to antipsychotic treatment. Genotyping of the disclosed SNPs can be used to predict response to antipsychotic drugs in patients suffering from schizophrenia. There is provided method of treating a subject with an antipsychotic medication comprising obtaining genetic information from the subject comprising the sequence of SNPs rs6923761, rs2300615, and rs1042044 to provide the GLP1 R Antipsychotic Response Phenotype (GARP) genetic signature of the subject; and administering an antipsychotic medication to the subject based on the GARP genetic signature of the subject.

Abstract: The invention includes method of determining if a subject is at risk for developing schizophrenia (SZ), schizotypal personality disorder (SPD), or schizoaffective disorder (SD).