Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: To restore consistency of a digital twin database, identifiers with metadata imported from various data sources are processed by an encoder, which computes latent representations of the identifiers that are compared by an efficient similarity metric. If the respective similarity score exceeds a threshold, a match is detected between the identifiers. In that case, the digital twin database is updated by aligning the first identifier and the second identifier. This matching algorithm for equipment identifiers updates the digital twin data automatically and continuously by aligning identifiers which refer to the same piece of equipment. The updates flow directly into the digital twin database, thereby removing the manual effort. Using approximate nearest neighbor methods is highly efficient, especially for large plants. The encoder is implemented as an autoencoder which relies only on unlabeled training data.

Abstract: The spray dried plasma by the nature of its characteristics and the process by which it is made allows for a dried plasma with reduced pathogens. It has at least three aspects of pathogen reduction that results in a plasma product with reduced or no pathogens. The first aspect relates to a spray drying disposable and machine that eliminates or minimizes the introduction of pathogens into the spray drying process and is referred to as the anti-contamination process. The second aspect of pathogen reduction relates to the spray drying process and parameters that reduces pathogens that may be present in the donor plasma, and/or inhibit pathogen growth and/or pathogen proliferation introduced by the donor plasma. The third aspect results in reduced pathogens occurring during storage of the dried plasma wherein the manufacturing and storage conditions are such that pathogens are reduced, and/or pathogen growth and/or pathogen proliferation are inhibited.

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the mean size of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment.

Abstract: A method of treating plasma with a pretreatment solution that has a physiologically compatible spray dry stable acidic substance (SDSAS) and an amino acid, prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.

Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof.

Abstract: A method and an apparatus for optimizing diagnostics of rotating equipment is provided. The apparatus includes a device for providing status information about status of the rotating equipment over a series of time windows whereby status can be derived from sensor features of at least one available sensor taking measurements during a predefinable time period, a device for using deep learning which combines provided historic sensor information with sequence of events data indicating warnings and/or alerts of the rotating equipment, whereby status information is supplemented with via deep learning predicted probabilities whether a warning and/or an alert has occurred within a time window, device for providing an amount of textual diagnostic knowledge cases, device for extracting semantic information on text features from the textual diagnostic knowledge cases, and device for combining status information and semantic information into a unified representation enabling optimization of the diagnostics.

Abstract: Provided is a method for determining output data for a plurality of text documents, including the steps of: providing a feature matrix as input data; wherein the feature matrix includes information about frequencies of a plurality of features within the plurality of text documents; clustering the feature matrix using a clustering algorithm into at least one clustering matrix; wherein the at least one clustering matrix includes information about the cluster membership of each document of the plurality of documents or each feature of the plurality of features, assigning at least one score to each feature of the plurality of features based on the at least one clustering matrix; ranking the plurality of features based on their assigned scores; and outputting the ranked features as output data. A corresponding computer program product and system is also provided.

Abstract: Provided is a method for determining output data for a plurality of text documents, including the steps of: providing a feature matrix as input data ; wherein the feature matrix includes information about frequencies of a plurality of features within the plurality of text documents; clustering the feature matrix using a clustering algorithm into at least one clustering matrix ; wherein the at least one clustering matrix includes information about the cluster membership of each document of the plurality of documents or each feature of the plurality of features, assigning at least one score to each feature of the plurality of features based on the at least one clustering matrix; ranking the plurality of features based on their assigned scores; and outputting the ranked features as output data. A corresponding computer program product and system is also provided.

Abstract: In an aspect, a kit of parts is provided for assembling at least a portion of a character figure. The kit includes first and second kit member each having a body having a representation of a body portion of the character figure thereon. The first kit member has a hook extending outwardly from the body, and the second kit member body has a first hook-receiving aperture which has an interior surface that frictionally engages the exterior surface of the first hook, and is free of any bight pass-through members that engage the bight of the first hook to prevent removal of the first kit member from the second kit member. The kit members are joinable together to form at least a portion of a character figure. The bight of the first hook permits the first kit member to be hung on a first storage bar.

Abstract: A method and an apparatus for optimizing diagnostics of rotating equipment, in particular a gas turbine is provided.

Abstract: A detachable garment or accessory is provided for a toy. The detachable garment or accessory includes at least a first front part and a second rear part pivotably or hingedly movable relative to each other via pivot or hinge means provided on or associated with the parts between an open position, wherein the garment or accessory can be attached to or removed from at least part of the toy, and a closed position, wherein the garment or accessory can be secured to the toy. Each of the at least first front part and second rear part include a top edge, a base edge and lateral edges. The pivot or hinge means provided between one or more of the lateral edges of said front and rear parts allow at least a portion of the lateral edges of the parts to be separated to form the open position and moved towards each other to form the closed position.

Abstract: The invention provides a security system and method for use in a communications network, said network comprising means to allow a plurality of devices to communicate over the network wherein at least one device is a machine to machine (M2M) operated device and at least one other device is a human operated device, said security system comprising: means to capture data traffic originating from the plurality of devices on the network; means for analysing the data traffic; and means for identifying at least one of the M2M operated devices on the network wherein the system is configured to dynamically adapt to different data traffic patterns on the network.

Abstract: The invention provides a network security method and system for use in a communications network, said network comprising a plurality of devices adapted to communicate over the network, at least one device capable of downloading or uploading an application over the network, said system comprises means for data capture on the network by receiving data from a first data source and a second data source; means for analysing comprising means for correlating data arising from network behaviour of at least one device obtained from the first data source and data from a second data source and means for generating a data structure; and based on said analyses of the generated data structure, means for identifying applications on devices which are behaving suspiciously.

Abstract: The invention provides a security system and method for use in a communications network, said network comprising means to allow a plurality of devices to communicate over the network wherein at least one device is a machine to machine (M2M) operated device and at least one other device is a human operated device, said security system comprising: means to capture data traffic originating from the plurality of devices on the network; means for analysing the data traffic; and means for identifying at least one of the M2M operated devices on the network wherein the system is configured to dynamically adapt to different data traffic patterns on the network.

Abstract: A detachable garment or accessory for a toy. The garment or accessory includes at least a first front part and a second rear part movable relative to each other via pivot or hinge means on or associated with the parts between an open position, wherein the garment or accessory can be attached to or removed from at least part of the toy, and a closed position, wherein the garment or accessory can be secured to the toy. Each part includes a top edge, a base edge and lateral edges. The pivot or hinge provided between one or more of the lateral edges of the front and rear parts allow at least a portion of the lateral edges of the parts to be separated to form the open position and moved towards each other to form the closed position.

Abstract: Suction Apparatus is provided including a body portion having at least a first suction surface for attachment to a suitable surface in use via suction. An aperture or channel is defined in said at least first suction surface.

Abstract: Toy apparatus is provided including a playbase (22) and at least a first toy member (16) movable relative to said playbase between at least first (36) and second (90) positions via movement means. The movement means are arranged so as to separate the at least first toy member a spaced distance apart from a surface of the playbase in moving said toy member between the at least first and second positions.

Abstract: Toy apparatus is provided including a playbase (22) and at least a first toy member (16) movable relative to said playbase between at least first (36) and second (90) positions via movement means.

Abstract: A microscope rheometer for measuring shear and compression properties of biological samples is disclosed. The apparatus allows a sample of biological tissue to be strained controllably while fluorescently stained cells, or other markers, within the material are imaged with a fluorescence microscope and the applied forces are measured with a strain gauge. Using the rheometer, it is possible to obtain the shear and compression stiffness of a material as a function of position.