Abstract: A method for controlling infections caused by protozoans, such as Cryptosporidium parvum, Plasmodium falciparum, and Leishmania donovani. The method comprises using syringomycin-family lipodepsipeptides, preferably syringomycins such as syringomycin E, to control or prevent infections caused by protozoans. The method is directed to therapeutic treatment of mammals, such as humans, exposed to protozoans, and additionally as a prophylactic treatment in immunocompromised subjects at high risk for contracting protozoan infections.

Abstract: A method for controlling infections caused by Cryptosporidium parvum. The method comprises using protease inhibiting compounds, preferably serine protease inhibitors, to inhibit excystation, invasion, and parasite maturation and development. The method is directed to therapeutic treatment of mammals, such as humans, exposed to C. parvum, and additionally as a prophylactic treatment in immunocompromised subjects at high risk for contracting cryptosporidiosis.

Abstract: The present invention relates to novel bacterial extract vaccines for use in veterinary medicine and to novel methods for preparing such vaccines. The bacteria responsible for a particular bacterially induced disease is contacted with a detergent so as to extract from the bacterial cells the antigens responsible for eliciting a protective immune response against the disease. Subsequently, the resultant antigen extract is dialyzed to remove the detergent. The antigen extract is then preferably combined with a vaccine enhancing adjuvant to provide an effective and inexpensive vaccine for veterinary application. The present invention provides for the preparation of a variety of vaccines which can be used to immunize animals against a variety of bacterially induced diseases.