Patents by Inventor Mark Cancilla
Mark Cancilla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
Patent number: 11932854Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.Type: GrantFiled: October 25, 2021Date of Patent: March 19, 2024Assignee: Sirna Therapeutics, Inc.Inventors: Mark Cancilla, James John Cunningham, William Michael Flanagan, Henry J. Haringsma, Denise M. Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron T. Willingham -
Patent number: 11854664Abstract: Embodiments of the present invention provide a computer-implemented system and method for generating and searching a database containing all of the potential substructures (e.g., metabolites) of a chosen complex molecule based on minimum cleavable units (MCUs) of the chosen complex molecule, wherein each record in the generated database suitably defines the molecular weight and physical arrangement of each substructure. Embodiments of the invention also provide a user interface and a search engine for searching the database based on a query molecular weight (or query molecular weight range) to identify all of the substructures having a total molecular weight matching the query molecular weight or range. Embodiments of the invention are also capable of transmitting to a display device operated by an end user a description and/or a graphical representation of every identified substructure of the chosen complex molecule.Type: GrantFiled: June 11, 2019Date of Patent: December 26, 2023Assignee: Merck Sharp & Dohme LLCInventors: Arthur Fridman, Ansuman Bagchi, Xiang Yu, Mark Cancilla
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RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (SINA)
Publication number: 20220195433Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (MAO against target gene expression.Type: ApplicationFiled: October 25, 2021Publication date: June 23, 2022Inventors: Mark Cancilla, James John Cunningham, William Michael Flanagan, Henry J. Haringsma, Denise M. Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron T. Willingham -
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
Patent number: 11193126Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.Type: GrantFiled: April 6, 2018Date of Patent: December 7, 2021Assignee: SIRNA THERAPEUTICS, INC.Inventors: Mark Cancilla, James John Cunningham, William Michael Flanagan, Henry J. Haringsma, Denise M. Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron T. Willingham -
Publication number: 20210265024Abstract: Embodiments of the present invention provide a computer-implemented system and method for generating and searching a database containing all of the potential substructures (e.g., metabolites) of a chosen complex molecule based on minimum cleavable units (MCUs) of the chosen complex molecule, wherein each record in the generated database suitably defines the molecular weight and physical arrangement of each substructure. Embodiments of the invention also provide a user interface and a search engine for searching the database based on a query molecular weight (or query molecular weight range) to identify all of the substructures having a total molecular weight matching the query molecular weight or range. Embodiments of the invention are also capable of transmitting to a display device operated by an end user a description and/or a graphical representation of every identified substructure of the chosen complex molecule.Type: ApplicationFiled: June 11, 2019Publication date: August 26, 2021Applicant: Merck Sharp & Dohme Corp.Inventors: Arthur FRIDMAN, Ansuman BAGCHI, Xiang YU, Mark CANCILLA
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Publication number: 20210257046Abstract: Embodiments of the present invention avoid the processing problems associated with using conventional computer systems for identifying and characterizing all of the substructures (e.g., metabolites) of large complex molecules by using a defined minimum cleavable unit (MCU) and an MCU graph for a chosen molecule, as well as a “cut vertex” in the MCU graph for the chosen molecule. The system splits the MCU graph of the chosen molecule at the specified cut vertex to produce two separate MCU graph components (i.e., a first MCU subgraph and a second MCU subgraph) of the chosen molecule, and generates and traverses a first line graph component and a second line graph component, respectively, for the two MCU subgraph components with a graph traversing algorithm to generate and store in memory a first database of substructures and molecular weights for the first component, and a second database of substructures and molecular weights for the second line graph component.Type: ApplicationFiled: June 11, 2019Publication date: August 19, 2021Applicant: Merck Sharp & Dohme Corp.Inventors: Arthur FRIDMAN, Ansuman BAGCHI, Xiang YU, Mark CANCILLA
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RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
Publication number: 20180362977Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.Type: ApplicationFiled: April 6, 2018Publication date: December 20, 2018Inventors: Mark Cancilla, James John Cunningham, William Michael Flanagan, Henry J. Haringsma, Denise M. Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron T. Willingham -
Patent number: 10107798Abstract: Herein is described a method to rapidly screen a large chemical space for a compound that binds to a target protein through an iterative fragment assembly approach that can be performed at low reagent cost and without requiring purification of the assembled product. The method employs a library of test ligands each of which comprise a ‘bait’ molecule, which is known from prior art or prior screening to have some intrinsic affinity for the target protein, and a test moiety.Type: GrantFiled: March 25, 2009Date of Patent: October 23, 2018Assignee: SUNESIS PHARMACEUTICALS, INC.Inventors: Stig Hansen, Daniel Erlanson, Mark Cancilla
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Publication number: 20180238863Abstract: Herein are described methods of chemical synthesis.Type: ApplicationFiled: January 12, 2018Publication date: August 23, 2018Applicant: Sunesis Pharmaceuticals, Inc.Inventors: Stig Hansen, Daniel Erlanson, Mark Cancilla
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RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
Patent number: 9970005Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.Type: GrantFiled: December 30, 2015Date of Patent: May 15, 2018Assignee: SIRNA THERAPEUTICS, INC.Inventors: Mark Cancilla, James John Cunningham, William Michael Flanagan, Henry J. Haringsma, Denise M. Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron T. Willingham -
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
Publication number: 20160264964Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.Type: ApplicationFiled: December 30, 2015Publication date: September 15, 2016Applicant: SIRNA THERAPEUTICS, INC.Inventors: Mark Cancilla, James John Cunningham, Michael William Flanagan, Henry J. Haringsma, Denise M. Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron T. Willingham -
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
Patent number: 9260471Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.Type: GrantFiled: October 25, 2011Date of Patent: February 16, 2016Assignee: Sirna Therapeutics, Inc.Inventors: Mark Cancilla, James J. Cunningham, Michael W. Flanagan, Henry J. Haringsma, Denise Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron Willingham -
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
Publication number: 20130217756Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.Type: ApplicationFiled: October 25, 2011Publication date: August 22, 2013Applicant: MERCK SHARP & DOHME CORP.Inventors: Mark Cancilla, James John Cunningham, Michael W. Flanagan, Henry J. Haringsma, Denise M. Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron T. Willingham -
Patent number: 5858047Abstract: An apparatus for shaping heat softened glass sheets includes a shaping station to receive a heat softened glass sheet to be shaped, first and second transfer stations positioned along opposing sides of the shaping station, and first and second cooling stations positioned adjacent a corresponding transfer station. An upper vacuum mold having first and second downwardly facing, shaped sheet engaging surfaces moves between the transfer stations and within the shaping station. The sheet engaging surfaces of the vacuum mold each have a shaped configuration generally corresponding to a final desired shaped of a glass sheet to be shaped. Heat softened glass sheets are positioned within the shaping station and moved into engagement with one of the sheet engaging surfaces to shape the sheet. Vacuum is drawn along the sheet engaging surface to hold the shaped sheet thereagainst.Type: GrantFiled: February 26, 1996Date of Patent: January 12, 1999Assignee: PPG Industries, Inc.Inventors: Robert G. Frank, Mark A. Cancilla