Patents by Inventor Mark Carlsen
Mark Carlsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240148722Abstract: The present invention relates to compounds that bind to TDP-43 and may have a therapeutic effect in treating a human disease, such as amyotrophic lateral sclerosis, frontotemporal lobar degeneration, hippocampal sclerosis of aging, chronic traumatic encephalopathy, inclusion body myositis, Alzheimer's disease, and/or Alzheimer's disease related disorders.Type: ApplicationFiled: February 20, 2022Publication date: May 9, 2024Inventors: Randall J. BINDER, Marianne CARLSEN, Xiao JIN, Mark E. MCDONNELL, Allen B. REITZ, Camille REMEUR, Eric STROBEL, Huji TURDI
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Patent number: 11912659Abstract: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.Type: GrantFiled: April 16, 2021Date of Patent: February 27, 2024Assignee: The Wistar Institute of Anatomy and BiologyInventors: Troy E. Messick, Garry R. Smith, Allen B. Reitz, Paul M. Lieberman, Mark E. McDonnell, Yan Zhang, Marianne Carlsen, Shuai Chen
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Publication number: 20230221591Abstract: The invention generally relates to systems and methods for controlling molecules. In certain aspects, the invention provides a system for controlling molecules, the system comprising: a first light source; a second light source; an acousto-optic modulator (AOM) coupled to the second light source; and control circuitry. In certain embodiments, the control circuitry may be configured to: receive a signal from the first light source that is interrogating a location in a sample that may contain a target molecule; compare the signal received from the first light source to a preset signal; and in the event that the signal received from the first light source meets or exceeds the preset signal, then the target molecule is present at the location in the sample and the control circuitry causes the AOM to activate the second light source to transmit light onto the location in the sample that contains the target molecule.Type: ApplicationFiled: January 13, 2023Publication date: July 13, 2023Inventors: Chi Zhang, Mark Carlsen, Matthew Clark
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Patent number: 10409047Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.Type: GrantFiled: October 4, 2017Date of Patent: September 10, 2019Assignee: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen, Suhas Sreehari
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Publication number: 20180045939Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.Type: ApplicationFiled: October 4, 2017Publication date: February 15, 2018Applicant: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen, Suhas Sreehari
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Patent number: 9784960Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.Type: GrantFiled: June 10, 2015Date of Patent: October 10, 2017Assignee: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen, Suhas Sreehari
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Publication number: 20160004060Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.Type: ApplicationFiled: June 10, 2015Publication date: January 7, 2016Applicant: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen
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Publication number: 20120137224Abstract: A system and a method to provide a personalized feed to a user. Information regarding the user is obtained from the user via customization content. The customization content indicates various categories of content for the user to select from. In response to the user selecting his or her categories of interest, a feed personalization module selects content pieces whose associated categories match the user selected categories. The feed personalization module then provides a personalized feed including these content pieces to the user. The personalized feed is provided to the user via a unique identifier assigned to the user. Using the unique identifier, the user's actions with respect to the provided feed is tracked. The feed is further re-personalized according to the user's actions. The feed is also re-personalized based on an input from the user indicating the relevance of the feed to the user's interests.Type: ApplicationFiled: November 21, 2011Publication date: May 31, 2012Applicant: SIMPLEFEED, INC.Inventors: Hilding Mark Carlsen, Vitaly Eliashberg