Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.

Abstract: Disclosed herein are compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed compositions can comprise a flavoring agent and polyethylene glycol. The disclosed compositions are superior to prior art compositions in that the disclosed compositions allow for higher tolerability, lower volumes, and improved patient compliance. In some embodiments, the composition comprises non-fermentable carbohydrates. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.

Abstract: A compression sock has a sock body including a top band, a sock front region, a sock rear region, and a sock bottom. A sweat ejection port is defined proximate the sock bottom. A sweat channel extends continuously from the top band to the ejection port. The sweat channel is made of a hydrophilic material embedded with ions effective to attract body sweat into the sweat channel. Separate cut-resistant front and rear shields may be integrated into front and rear regions of the sock.

Abstract: A gyroscopic device may be used as a power generator. In some embodiments there is provided a power generator which comprises a housing, a flywheel disposed within the housing and rotatable about an extending along a first axis, a precessional rotation assembly to implement rotation of the housing about a precessional axis of the flywheel, and a precessional generator to capture energy generated by the precessional rotation of the housing. Other embodiments may be described.

Abstract: Apparatuses, systems, and methods provide for high density laminated sheet windings in axial and radial flux configurations. According to embodiments described herein, motor components such as a rotor or stator include a number of stacked sheets of conductive material. The stacked sheets are electrically connected in series to create a winding. Each motor component includes a number of conductors spaced apart with apertures between. The motor components are stacked and configured with the conductors of one rotor or stator positioned within the apertures of the other rotor or stator to create a thin, high density conductor. A magnemotive force is created when the magnetic flux is positioned over the conductors.

Abstract: Apparatuses, systems, and methods provide for high density laminated sheet windings in axial and radial flux configurations. According to embodiments described herein, motor components such as a rotor or stator include a number of stacked sheets of conductive material. The stacked sheets are electrically connected in series to create a winding. Each motor component includes a number of conductors spaced apart with apertures between. The motor components are stacked and configured with the conductors of one rotor or stator positioned within the apertures of the other rotor or stator to create a thin, high density conductor. A magnemotive force is created when the magnetic flux is positioned over the conductors.

Abstract: Higher-order Halbach permanent magnet arrays that produce higher flux densities in the air gaps of electromotive machines are described. In one embodiment, a second order “Hyper” Halbach array includes a plurality of magnets arranged immediately adjacent to each other so as to define a rectangular matrix having rows and columns in which the respective magnetic fields of a first row of the array are arranged so as to define a conventional first order Halbach array, and, proceeding in a column direction of the array, the respective magnetic fields of the magnets of each of a second and succeeding rows of the array are respectively rotated counter-clockwise about an axis perpendicular to the column direction of the array through successive 90 degree rotations relative to those of the immediately preceding row.

Abstract: A gyroscopic device may be used as a power generator. In some embodiments there is provided a power generator which comprises a housing, a flywheel disposed within the housing and rotatable about an extending along a first axis, a precessional rotation assembly to implement rotation of the housing about a precessional axis of the flywheel, and a precessional generator to capture energy generated by the precessional rotation of the housing. Other embodiments may be described.

Abstract: Electric motor configurations are provided with Halbach arrays. In one example, an electric motor includes a first plurality of magnets arranged in a first Halbach array. The first plurality of magnets is configured to provide a first magnetic field that substantially exhibits a first Halbach flux distribution. A first plurality of electromagnets comprising a first plurality of coils are arranged in a second Halbach array. A controller is adapted to selectively direct current through the first plurality of coils to induce a second magnetic field to interact with the first magnetic field. The second magnetic field substantially exhibits a second Halbach flux distribution.

Abstract: Electric motor configurations are provided with Halbach arrays. In one example, an electric motor includes a first plurality of magnets arranged in a first Halbach array. The first plurality of magnets is configured to provide a first magnetic field that substantially exhibits a first Halbach flux distribution. A first plurality of electromagnets comprising a first plurality of coils are arranged in a second Halbach array. A controller is adapted to selectively direct current through the first plurality of coils to induce a second magnetic field to interact with the first magnetic field. The second magnetic field substantially exhibits a second Halbach flux distribution.

Abstract: Stimulant laxative in combination with an osmotic laxative produces safe and effective bowel and colon cleansing with a reduced volume of liquid input. Administering to a patient an oral stimulant laxative, such as bisacodyl, followed, after a biologically determined interval, by a reduced volume of a PEG in water solution cleanses the bowels and colon in preparation for diagnostic colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of large volume isotonic lavages, or smaller volume hypertonic lavages.

Abstract: Methods and apparatus are provided for a low shock separation joint. The separation joint comprises a male member, a female member, and an explosive device. At least one projection is formed on the male and female members. Surfaces of the at least one projection on the male and female members are mated to one another to prevent separation under compressive and tensile forces. The explosive device is placed within a cavity of the female member. A method for reducing shock in a separation joint is provided. An explosive device in the female member of the separation joint is detonated. A volume increase of the explosive device bends flanges of the female member away from one another. Surfaces in intimate contact with one another are moved out of contact with one another to decouple the male member from the female member.

Abstract: Methods and apparatus are provided for a low shock separation joint. A first member couples to a first structure and includes surfaces to prevent separation under compressive and tensile force placed on the separation joint. A second member couples to a second structure and includes surfaces corresponding to the surfaces of the first member. The first member is elastically flexed to allow the surfaces of the first and second members to be aligned to one another. The first member is released from flexing which couples the first and second members together. An explosive device is placed within the separation joint. Detonating the explosive device moves the surfaces of the first and second members out of contact with one another decoupling the first and second members. A passive force is applied to accelerate the first and second members away from one another. After detonation the first and second members are intact.

Abstract: Methods and apparatus are provided for a low shock separation joint. The separation joint comprises a male member, a female member, and an explosive device. At least one projection is formed on the male and female members. Surfaces of the at least one projection on the male and female members are mated to one another to prevent separation under compressive and tensile forces. The explosive device is placed within a cavity of said female member. A method for reducing shock in a separation joint is provided. An explosive device in the female member of the separation joint is detonated. A volume increase of the explosive device bends flanges of the female member away from one another. Surfaces in intimate contact with one another are moved out of contact with one another to decouple the male member from the female member.

Abstract: The invention provides a method for treating irritable bowel syndrome, comprising administering an osmotic laxative and fiber in a therapeutically effective regimen to a patient in need of such treatment. The therapeutically effective regimen includes administering the formulation in a dose and at a frequency and duration sufficient to reduce or eliminate the symptoms of irritable bowel syndrome or to provide symptomatic or palliative relief to the patient.

Abstract: Methods and apparatus are provided for a low shock separation joint. A first member couples to a first structure and includes surfaces to prevent separation under compressive and tensile force placed on the separation joint. A second member couples to a second structure and includes surfaces corresponding to the surfaces of the first member. The first member is elastically flexed to allow the surfaces of the first and second members to be aligned to one another. The first member is released from flexing which couples the first and second members together. An explosive device is placed within the separation joint. Detonating the explosive device moves the surfaces of the first and second members out of contact with one another decoupling the first and second members. A passive force is applied to accelerate the first and second members away from one another. After detonation the first and second members are intact.

Abstract: Apparatus is provided for an acoustical composite construction especially designed for use in a launch vehicle fairing. The acoustical composite construction includes a low density core material having a first side and a second side. A first sheet of rigid face material is bonded to the first side with a visco elastic adhesive, and a second sheet of rigid face material is bonded to the second side with a visco elastic adhesive. The construction is then oven cured or air cured under vacuum bag pressure only.

Abstract: A launch vehicle assembly has a launch vehicle body (10) having a first slot (48a) therein. A first magnet (50a) is disposed within the first slot (43a). A fairing assembly (12) is positioned adjacent to the vehicle body (10). The fairing assembly (12) has a second slot (30a) therein positioned opposite the first slot (48a). A second magnet (40a) is disposed within the second slot (30a) so that the second magnet (40a) repels the first magnet (50a).

Abstract: A launch vehicle assembly has a launch vehicle body (10) having a first slot (48a) therein. A first magnet (50a) is disposed within the first slot (43a). A fairing assembly (12) is positioned adjacent to the vehicle body (10). The fairing assembly (12) has a second slot (30a) therein positioned opposite the first slot (48a). A second magnet (40a) is disposed within the second slot (30a) so that the second magnet (40a) repels the first magnet (50a).