Patents by Inventor Mark D. Holt
Mark D. Holt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220218002Abstract: Method of producing a feedstuff for a dairy animal that potentiates milk production. The method includes a multi-stage process having one stage in which a feed grain for dairy animals is heat-treated for a period of time at a temperature above 90 degrees Celsius. The grain is processed for another period of time that includes disrupting the prolamin/protein bonds which produces a hydrophilic, vitreous feedstuff having a starch and protein matrix composed at least partially by prolamin. The feed grain is heat-treated for a first period of time, of which at least 200 seconds is maintained above 90 degrees Celsius, and thereafter the feed grain is processed in a second stage by applying sufficient processing to disrupt the prolamin/protein bonds and thereby producing a hydrophilic, vitreous, feedstuff comprising a starch and protein matrix composed of at least three percent prolamin.Type: ApplicationFiled: February 7, 2022Publication date: July 14, 2022Inventor: Mark D. Holt
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Publication number: 20220152308Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: ApplicationFiled: February 1, 2022Publication date: May 19, 2022Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Patent number: 11298463Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: April 3, 2020Date of Patent: April 12, 2022Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Patent number: 11273260Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: June 17, 2021Date of Patent: March 15, 2022Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Patent number: 11160931Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: May 2, 2019Date of Patent: November 2, 2021Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Publication number: 20210308381Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: ApplicationFiled: June 17, 2021Publication date: October 7, 2021Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Patent number: 11129941Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: February 19, 2016Date of Patent: September 28, 2021Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Son C. Tran, Sheldon Moberg, Mark D. Holt
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Patent number: 11110225Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: May 8, 2018Date of Patent: September 7, 2021Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Patent number: 11058821Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: November 18, 2019Date of Patent: July 13, 2021Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Publication number: 20200230323Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: ApplicationFiled: April 3, 2020Publication date: July 23, 2020Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Publication number: 20200179609Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: ApplicationFiled: November 18, 2019Publication date: June 11, 2020Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Patent number: 10537681Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: February 10, 2016Date of Patent: January 21, 2020Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Patent number: 10537682Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: February 19, 2016Date of Patent: January 21, 2020Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Publication number: 20190298927Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: ApplicationFiled: May 2, 2019Publication date: October 3, 2019Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Publication number: 20190261652Abstract: Method of producing a feedstuff for a dairy animal that potentiates milk production. The method includes a multi-stage process having one stage in which a feed grain for dairy animals is heat-treated for a period of time at a temperature above 90 degrees Celsius. The grain is processed for another period of time that includes disrupting the prolamin/protein bonds which produces a hydrophilic, vitreous feedstuff having a starch and protein matrix composed at least partially by prolamin. The feed grain is heat-treated for a first period of time, of which at least 200 seconds is maintained above 90 degrees Celsius, and thereafter the feed grain is processed in a second stage by applying sufficient processing to disrupt the prolamin/protein bonds and thereby producing a hydrophilic, vitreous, feedstuff comprising a starch and protein matrix composed of at least three percent prolamin.Type: ApplicationFiled: May 9, 2019Publication date: August 29, 2019Inventor: Mark D. Holt
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Patent number: 10314976Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: February 10, 2016Date of Patent: June 11, 2019Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Publication number: 20180256821Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: ApplicationFiled: May 8, 2018Publication date: September 13, 2018Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Patent number: 9987428Abstract: An injector (100) may include a container (102) having a wall (110) with an interior surface (112) and a seal assembly (140) with an interior surface (142), the interior surfaces (110) of the wall (110) and the seal assembly (140) defining a closed sterile reservoir (150) filled with a drug product. The injector (100) may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle (180) having a point (182) disposed only partially through the seal assembly (140) in a storage state, and disposed through the interior surface (142) of the seal assembly (140) into the sterile reservoir (150) in a delivery state. Further, the injection may include an actuator (106) that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: October 11, 2012Date of Patent: June 5, 2018Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Publication number: 20170143586Abstract: A vial adapter includes a base having first and second opposing sides, a spike depending from the first side of the base, the spike having a spike passageway, and a connector disposed on the second side of the base, the connector having a connector passageway that is in fluid communication with the spike passageway. The vial adapter may be combined with a vial.Type: ApplicationFiled: February 3, 2017Publication date: May 25, 2017Inventors: Mark D. Holt, Alexander Stuart Cairns
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Publication number: 20170007667Abstract: Method of producing a feedstuff for a dairy animal that potentiates milk production. The method includes a multi-stage process having one stage in which a feed grain for dairy animals is heat-treated for a period of time at a temperature above 90 degrees Celsius. The grain is processed for another period of time that includes disrupting the prolamin/protein bonds which produces a hydrophilic, vitreous feedstuff having a starch and protein matrix composed at least partially by prolamin. The feed grain is heat-treated for a first period of time, of which at least 200 seconds is maintained above 90 degrees Celsius, and thereafter the feed grain is processed in a second stage by applying sufficient processing to disrupt the prolamin/protein bonds and thereby producing a hydrophilic, vitreous, feedstuff comprising a starch and protein matrix composed of at least three percent prolamin.Type: ApplicationFiled: September 19, 2016Publication date: January 12, 2017Inventors: Mark D. Holt, Matthew Ryan Garner