Abstract: Provided is a compound of formula I, or pharmaceutically acceptable salt or solvate thereof, as defined herein for use in the treatment or prevention of a Dirofilaria infection in a mammal, The compounds are also for use in the treatment or prevention of diseases or conditions caused by a Dirofilaria infection in a mammal. Also described are corresponding methods of treating or preventing a Dirofilaria infection in a mammal.

Abstract: A speaker can have a main body with a generally spheroidal shape, which can be supported standing on its end. The speaker can include a subwoofer that faces forward. A plurality of mid-range drivers can be distributed around the sub-woofer, facing generally forward and radially outward. A plurality of tweeters can be distributed around the sub-woofer, facing generally forward and generally outward. The outer housing portion of the speaker can be covered with a fabric material. A user interface ring 162 can be touch sensitive to receive input, and can have a plurality of lights that can be illuminated separately to convey information to the user.

Abstract: An engine that has, in axial flow series, booster compressor, core compressor, combustion equipment, core turbine, and low-pressure turbine. Core turbine drives core compressor via an interconnecting high-pressure shaft. Low-pressure turbine drives booster compressor via an interconnecting low-pressure shaft. Low-pressure turbine also drives external load having a defined speed characteristic that dictates speed of the low-pressure turbine and booster compressor. Booster compressor has one or more rows of variable stator vanes. The method includes: scheduling variation in the angle of variable stator vanes as a function of speed of the booster compressor wherein the vanes open as booster compressor speed increases; measuring or setting one or more operational parameters which are determinative of temperature at entry to core turbine; and biasing scheduling of angle variation of variable stator vanes as a function of operational parameter(s) to reduce variation in temperature at entry to core turbine.

Abstract: An engine that has, in axial flow series, booster compressor, core compressor, combustion equipment, core turbine, and low-pressure turbine. Core turbine drives core compressor via an interconnecting high-pressure shaft. Low-pressure turbine drives booster compressor via an interconnecting low-pressure shaft. Low-pressure turbine also drives external load having a defined speed characteristic that dictates speed of the low-pressure turbine and booster compressor. Booster compressor has one or more rows of variable stator vanes. The method includes: scheduling variation in the angle of variable stator vanes as a function of speed of the booster compressor wherein the vanes open as booster compressor speed increases; measuring or setting one or more operational parameters which are determinative of temperature at entry to core turbine; and biasing scheduling of angle variation of variable stator vanes as a function of operational parameter(s) to reduce variation in temperature at entry to core turbine.

Abstract: A method of shear-thinning a slurry includes transferring slurry to be shear-thinned from a primary vessel or reservoir to a secondary vessel or reservoir, withdrawing at least a portion of the slurry in the secondary vessel or reservoir by means of a pump or motive device as a shear device thereby shear-thinning the withdrawn slurry, and returning or recycling at least a portion of the shear-thinned slurry back to the secondary vessel or reservoir. The slurry is withdrawn through an outlet from the secondary vessel or reservoir and is returned to the secondary vessel or reservoir through an inlet into the secondary vessel or reservoir with the inlet being spaced from the outlet.

Abstract: A method of operating a contra-rotating propeller engine that preferably comprises a 12 bladed front and a 9 bladed rear propeller. As is conventional, the engine is operated during at least a take-off phase, a cruise phase and an approach phase; during the cruise phase the engine operates with a generally constant propeller tip speed. The method is characterized by the step of operating the engine such that the tip speed of either or both of the propellers, during at least one of take-off, climb or approach, at least 10% greater than cruise tip speed. With a specific front to rear propeller spacing, increasing the tip speed reduces overall noise generated by the propellers.

Abstract: A gas turbine engine having three shafts connecting respective high, intermediate and low-pressure turbines and compressors is characterised by an intermediate pressure turbine that includes two rotor stages.