Abstract: The invention relates to treatments for coronavirus infections by administering a neutrophil elastase inhibitor, such as alvelestat.

Abstract: The present disclosure provides compounds effective in increasing mucociliary clearance in a subject. In one embodiment, the compounds are of the general formula I. The present disclosure further shows that such compounds are effective in increasing activation of the CFTR, thereby increasing mucociliary clearance in the subject. The present disclosure further shows that such compounds are effective in increasing the depth of ASL, thereby increasing mucociliary clearance in the subject. In one embodiment of each of the foregoing, the subject is free from congenital or genetic defect in the cellular mucociliary clearance apparatus and/or acquired abnormality in the cellular mucociliary clearance apparatus.

Abstract: The present disclosure provides compounds effective in increasing mucociliary clearance in a subject. In one embodiment, the compounds are of the general formula I. The present disclosure further shows that such compounds are effective in increasing activation of the CFTR, thereby increasing mucociliary clearance in the subject. The present disclosure further shows that such compounds are effective in increasing the depth of ASL, thereby increasing mucociliary clearance in the subject. In one embodiment of each of the foregoing, the subject is free from congenital or genetic defect in the cellular mucociliary clearance apparatus and/or acquired abnormality in the cellular mucociliary clearance apparatus.

Abstract: Systems and methods for a gravity survey using a free-fall gravity sensor are disclosed. The method includes determining a configuration for a gravimeter for use in a moving-base gravity survey. The gravimeter is operable to obtain absolute gravity measurements. The method further includes obtaining a set of gravity data from the moving-base gravity survey, and correcting the set of gravity data for interference. The method additionally includes generating a gravity model based on the corrected set of gravity data.

Abstract: The present disclosure provides compounds effective in increasing mucociliary clearance in a subject. In one embodiment, the compounds are of the general formula I. The present disclosure further shows that such compounds are effective in increasing activation of the CFTR, thereby increasing mucociliary clearance in the subject. The present disclosure further shows that such compounds are effective in increasing the depth of ASL, thereby increasing mucociliary clearance in the subject. In one embodiment of each of the foregoing, the subject is free from congenital or genetic defect in the cellular mucociliary clearance apparatus and/or acquired abnormality in the cellular mucociliary clearance apparatus.

Abstract: An aircraft equipped for airborne vector magnetic exploration surveys comprising three magnetometers orthogonally mounted to measure the components of the earth's vector magnetic field; two rotation sensors mounted to measure the angular orientation of the aircraft; and a recording system to record the measurements of the magnetometers, and rotation sensors. The measured angular orientation is used to orientate the measured components of the earth's vector magnetic field to derive true vector aero-magnetic (VAM) data from airborne surveys. Also disclosed is a method for processing magnetic data by removing the permanent, induced, and eddy-current magnetic effects of the aircraft from the magnetic data.

Abstract: An aircraft equipped for airborne vector magnetic exploration surveys comprising three magnetometers orthogonally mounted to measure the components of the earth's vector magnetic field; two rotation sensors mounted to measure the angular orientation of the aircraft; and a recording system to record the measurements of the magnetometers, and rotation sensors. The measured angular orientation is used to orientate the measured components of the earth's vector magnetic field to derive true vector acro-magnetic (VAM) data from airborne surveys. Also disclosed is a method for processing magnetic data by removing the permanent, induced, and eddy-current magnetic effects of the aircraft from the magnetic data.