Patents by Inventor Mark E. Bolander

Mark E. Bolander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100119528
    Abstract: Novel carrier peptides are described, as well as methods of using the carrier peptides to transport biologically active molecules into a cell, mitochondrion, or nucleus, e.g., by formation of a complex of the carrier peptide non-covalently bound to a biologically active molecule.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 13, 2010
    Inventors: Gobinda Sarkar, Mark E. Bolander, Deendayal Mandal, Eric W. Mahlum, Michael J. Yaszemski
  • Patent number: 6562572
    Abstract: Methods for identifying differentially expressed mRNA molecules are described, as well as methods for amplifying nucleic acid sequences.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: May 13, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Gobinda Sarkar, Mark E. Bolander
  • Publication number: 20030078227
    Abstract: A method for the delivery of substances to a cell is disclosed. In a preferred embodiment, one administers continuous wave ultrasound or pulse-wave ultrasound to a cell bathed in a cocktail containing macromolecules and monitors the ultrasound using reflected echoes of the ultrasound. One then observes incorporation of the substances into the cell. In a preferred embodiment of the present invention, macromolecules are combined in a cocktail solution comprising bubble micronuclei.
    Type: Application
    Filed: July 11, 2002
    Publication date: April 24, 2003
    Inventors: James F. Greenleaf, Mark E. Bolander, William J. Greenleaf
  • Publication number: 20010053384
    Abstract: A method for the delivery of substances to a cell is disclosed. In a preferred embodiment, one administers continuous wave ultrasound or pulse-wave ultrasound to a cell bathed in a cocktail containing macromolecules and monitors the ultrasound using reflected echos of the ultrasound. One then observes incorporation of the substances into the cell. In a preferred embodiment of the present invention, macromolecules are combined in a cocktail solution comprising bubble micronuclei.
    Type: Application
    Filed: July 2, 1998
    Publication date: December 20, 2001
    Inventors: JAMES F. GREENLEAF, MARK E. BOLANDER, WILLIAM J. GREENLEAF
  • Patent number: 4902296
    Abstract: A grafting material comprising milled bone which has an initial coating of guanidine-extracted bone proteins which are dialyzed from solution. Unbound bone proteins are removed and this augmented milled bone is lyophized. A subsequent coat of anti-coagulated plasma containing plasma proteins is applied to the augmented milled bone. The unbound plasma proteins are removed from the coating by rinsing.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: February 20, 1990
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventors: Mark E. Bolander, Gary Balian
  • Patent number: 4743259
    Abstract: A process of grafting material from milled bone is disclosed which comprises augmenting the bone protein of a first quantity of milled bone by dialyzing from solution guanidine-extracted bone proteins from a second quantity of milled bone and adding the extracted proteins to the first quantity of milled bone. Next, unbound proteins are removed and then the augmented milled bone is lypohilized, after which the augmented milled bone is coated with anti-coagulated plasma containing plasma proteins. Any unbound plasma protein is removed from the coating by rinsing.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: May 10, 1988
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventors: Mark E. Bolander, Gary Balian