Patents by Inventor Mark E. Bosworth

Mark E. Bosworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic liposomal compositions for enhancing NMR imaging
    Patent number: 5407660
    Abstract: Nuclear magnetic resonance (NMR) imaging of body organs and tissues is enhanced by administering to a living animal body a diagnostic composition comprising a diagnostically effective amount of a substantially nontoxic paramagnetic image altering agent containing a chelate of a paramagnetic element such as magnesium, gadolinium or iron, carried by a liposome. The chelate is carried by or within or outside the external surface of the liposome in such a manner that after arrival at or delivery to the desired organ or tissue site, the paramagnetic image altering agent is released in a diagnostically useful fashion.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: April 18, 1995
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Mark E. Bosworth, Ronald M. Hopkins
  • Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes
    Patent number: 5387410
    Abstract: Nuclear magnetic resonance (NMR) imaging of body organs and tissues is enhanced by administering to a living animal body a substantially nontoxic paramagnetic image altering agent comprised of a composition containing a chelate of a paramagnetic element, such as manganese, gadolinium or iron, carried by a liposome. The chelate is carried by or within the external surface of the liposome in such a manner that after arrival at or delivery to the desired organ or tissue site, the paramagnetic image altering agent is released in a diagnostically useful fashion.
    Type: Grant
    Filed: February 15, 1989
    Date of Patent: February 7, 1995
    Assignee: Mallinckrodt, Inc.
    Inventors: Mark E. Bosworth, Ronald M. Hopkins
  • Purification of X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals using reverse osmosis
    Patent number: 5221485
    Abstract: The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals are purified by passing through a cross-linked reverse osmosis membrane.
    Type: Grant
    Filed: October 2, 1992
    Date of Patent: June 22, 1993
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Mark E. Bosworth, Thomas J. Dunn, Warren E. Hall, Richard G. Johnson, Mills T. Kneller, Youlin Lin, Rebecca A. Wallace, David H. White, David M. Wong
  • Purification of crude Ioversol using reverse osmosis
    Patent number: 5160437
    Abstract: The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. In the purification process a crude Ioversol solution is contacted with a cross-linked membrane under pressure, forcing the low molecular weight impurities within the crude Ioversol solution through the membrane pores and retaining Ioversol molecules.
    Type: Grant
    Filed: December 3, 1991
    Date of Patent: November 3, 1992
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Mark E. Bosworth, Thomas J. Dunn, Warren E. Hall, Richard G. Johnson, Mills T. Kneller, Youlin Lin, Rebecca A. Wallace, David H. White, David M. Wong
  • Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent
    Patent number: 5078986
    Abstract: Nuclear magnetic resonance (NMR) imaging of body organs and tissues is enhanced by administering to a living animal body a substantially nontoxic paramagnetic image altering agent comprised of a composition containing a chelate of a paramagnetic element, such as manganese, gadolinium or iron, carried by a liposome. The chelate is carried by or within the external surface of the liposome in such a manner that after arrival at or delivery to the desired organ or tissue site, the paramagnetic image altering agent is released in a diagnostically useful fashion.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: January 7, 1992
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Mark E. Bosworth, Ronald M. Hopkins