Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Abstract: A pressure regulator having a housing with an inlet port and an outlet port. A plug is located within the housing and dividing the housing into an upper chamber and a lower chamber, with the upper and lower chamber being connected by a vent. The plug includes a fluid path between the inlet port and the bore. A yoke is adapted selectively close the fluid path in the plug. A diaphragm is located in the upper chamber and is connected to the yoke. A biasing member biases the yoke to open the fluid path through the plug. The diaphragm is configured to move the yoke to open the fluid path when pressure in the lower chamber and vented to the upper chamber through the vent is above a predetermined amount. The pressure regulator can also include a second biasing member used to positively close the fluid path through the plug.

Abstract: A pressure regulator having a housing with an inlet port and an outlet port. A plug is located within the housing and dividing the housing into an upper chamber and a lower chamber, with the upper and lower chamber being connected by a vent. The plug includes a fluid path between the inlet port and the bore. A yoke is adapted selectively close the fluid path in the plug. A diaphragm is located in the upper chamber and is connected to the yoke. A biasing member biases the yoke to open the fluid path through the plug. The diaphragm is configured to move the yoke to open the fluid path when pressure in the lower chamber and vented to the upper chamber through the vent is above a predetermined amount. The pressure regulator can also include a second biasing member used to positively close the fluid path through the plug.

Abstract: A pressure regulator having a housing with an inlet port and an outlet port. A plug is located within the housing and dividing the housing into an upper chamber and a lower chamber, with the upper and lower chamber being connected by a vent. The plug includes a fluid path between the inlet port and the bore. A yoke is adapted selectively close the fluid path in the plug. A diaphragm is located in the upper chamber and is connected to the yoke. A biasing member biases the yoke to open the fluid path through the plug. The diaphragm is configured to move the yoke to open the fluid path when pressure in the lower chamber and vented to the upper chamber through the vent is above a predetermined amount. The pressure regulator can also include a second biasing member used to positively close the fluid path through the plug.

Abstract: A pressure regulator having a housing with an inlet port and an outlet port. A plug is located within the housing and dividing the housing into an upper chamber and a lower chamber, with the upper and lower chamber being connected by a vent. The plug includes a fluid path between the inlet port and the bore. A yoke is adapted selectively close the fluid path in the plug. A diaphragm is located in the upper chamber and is connected to the yoke. A biasing member biases the yoke to open the fluid path through the plug. The diaphragm is configured to move the yoke to open the fluid path when pressure in the lower chamber and vented to the upper chamber through the vent is above a predetermined amount. The pressure regulator can also include a second biasing member used to positively close the fluid path through the plug.

Abstract: A two stage gas pressure regulator with a body housing having a gas inlet and a gas outlet, and a common interior wall dividing the body housing into two chambers forming two pressure reducing stages. Respective intersecting fluid passageways through the common interior wall communicate the first stage to the second stage and provide a gauge pressure tap on the body housing, the intersecting passageways meeting at an intersection point within the common interior wall. Respective diaphragms are provided for each stage, and a cover has a vent venting the volume defined between the cover and the second stage diaphragm. A small passageway is provided in a common cover wall between the two stages, the small passageway being sized to suitably vent both cover portions above the respective diaphragms through the vent while eliminating overpressurization of the second stage in the event of pressure regulating failure of the first stage.

Abstract: A fluid flow regulator having a spring clip frictionally engaging the pivoting regulator lever to stabilize flow fluctuations. Alternatively, a disk wedge with opposite leg portions frictionally engages the moving regulator diaphragm.

Abstract: A self-operated droop compensated regulator includes a spring casing and a lower casing, sandwiching a diaphragm. The lower casing has inlet and outlet ports. A one piece cam stem and relief seat is mounted for movement with the diaphragm and includes a first cam surface for directly engaging a movable disk holder. The disk holder is movable in a straight line within an orifice tube that supports the valve seat. The cam surface moves the disk holder at a nonlinear rate with respect to the diaphragm. A pressure relief mechanism is incorporated within the upper portion of the diaphragm. A bias spring acts, between a second similar cam surface on the opposite side of the stem and the disk holder, to maintain the first cam surface in contact with the disk holder. The orifice tube has a removable boost end cap for providing a boost action to the diaphragm.

Abstract: A self-operated droop compensated regulator includes a spring casing and a lower casing, sandwiching a diaphragm. The lower casing has axially aligned inlet and outlet ports. A one piece cam stem and relief seat is mounted for movement with the diaphragm and includes a first cam surface for directly engaging a movable disk holder. The disk holder is movable in a straight line within an orifice tube that supports the valve seat. The cam surface moves the disk holder at a nonlinear rate with respect to the diaphragm. The orifice tube has an extension for providing a boost action to the diaphragm. A pressure relief mechanism is incorporated within the upper portion of the diaphragm. A bias spring acts, between a second similar cam surface on the opposite side of the stem and the disk holder, to maintain the first cam surface in contact with the disk holder.