Patents by Inventor Mark E. Meyerhoff
Mark E. Meyerhoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11724260Abstract: Provided herein is technology relating to microfluidics and particularly, but not exclusively, to devices, methods, and systems for detecting and/or quantifying analytes in samples using a microfluidic sensor device comprising an oil phase that segments aqueous samples into droplets and provides oil segments that are highly selective chemical sensors for adjacent aqueous droplets.Type: GrantFiled: April 6, 2020Date of Patent: August 15, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Xuewei Wang, Mark E Meyerhoff, Ryan Castle Bailey
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Publication number: 20230084608Abstract: A method includes mixing a liquid carrier and a powder formulation including an S-nitrosothiol (RSNO) powder to form a nitric oxide generating solution; and within a predetermined time of mixing, introducing the nitric oxide generating solution into an inflatable and nitric oxide permeable balloon of a urinary catheter that is inserted in a patient.Type: ApplicationFiled: March 31, 2021Publication date: March 16, 2023Inventors: Mark E. Meyerhoff, Orsolya I. Lautner-Csorba, Griffin Murray, Gergely Lautner, Alexander S. Yevzlin, Karthik Ramani
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Patent number: 11571538Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.Type: GrantFiled: April 11, 2018Date of Patent: February 7, 2023Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Nicolai Lehnert, Yu Qin, Andrew Hunt, Elizabeth J. Brisbois, Hang Ren
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Patent number: 11439609Abstract: A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.Type: GrantFiled: June 10, 2016Date of Patent: September 13, 2022Assignee: The Regents of the University of MichiganInventors: Gergely Lautner, Steven P. Schwendeman, Mark E. Meyerhoff
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Patent number: 11413420Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: GrantFiled: January 24, 2020Date of Patent: August 16, 2022Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Publication number: 20220218880Abstract: A catheter insert device includes a powder composition, and a housing. The powder composition includes a solid phase S-nitrosothiol (RSNO). The housing includes a polymeric wall that is i) permeable to nitric oxide, ii) non-porous, and iii) permeable to water vapor, and an inner lumen defined at least in part by the polymeric wall. The powder composition is completely sealed within the inner lumen of the housing.Type: ApplicationFiled: June 9, 2020Publication date: July 14, 2022Inventors: Maria Kim, Elizabeth J. Brisbois, Joshua C. Doverspike, Shale J. Mack, Orsolya I. Lautner-Csorba, Kamila Katarzyna Konopinska, Mark E. Meyerhoff
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Publication number: 20220176062Abstract: An example of a nitric oxide (NO) generating system includes an NO generating formulation, having: a stable NO donor/adduct; a hydrophilic binder; and an additive. The additive is to control a rate of release of NO from the stable NO donor/adduct after the formulation is exposed to an effective amount of water, water vapor, or blue or ultraviolet (UV) light. This example NO generating system further includes an inhalation device in operative contact with the NO generating formulation.Type: ApplicationFiled: February 22, 2022Publication date: June 9, 2022Inventors: Glenn Martin, Aurora L. Fernandez DeCastro, Mark E. Meyerhoff
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Publication number: 20220111173Abstract: Gas delivery devices include different examples of nitric oxide (NO) generating systems. Each example of the NO generating system includes a solid, light sensitive NO donor, and a light source that is operatively positioned to selectively expose the solid, light sensitive NO donor to light in order to generate NO gas.Type: ApplicationFiled: September 27, 2019Publication date: April 14, 2022Inventors: Gergely Lautner, Blake Stringer, Elizabeth J. Brisbois, Mark E. Meyerhoff, Steven P. Schwendeman
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Patent number: 11103622Abstract: A polymeric film includes a polymer matrix having at least one of a discrete RSNO adduct or a polymeric RSNO adduct associated therewith, by: covalent attachment to the polymer matrix; dispersion within the polymer matrix; or both, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymer matrix is a polyurethane polymer matrix, a silicone rubber polymer matrix, or a copolymer matrix of polyurethane and silicone rubber. The polymeric film is to exhibit stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to moisture or light capable of photolyzing an RSNO bond, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.Type: GrantFiled: February 6, 2014Date of Patent: August 31, 2021Assignee: The Regents of the University of MichiganInventors: Elizabeth J. Brisbois, Hitesh Handa, Mark E. Meyerhoff
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Publication number: 20210178106Abstract: A moisture or hydrating liquid activatable solid formulation for nitric oxide (NO) generation includes a nitrite source; a copper (I) or copper (II) catalyst; an NO generation accelerant; and a solid pH buffer. The nitrite source is to generate NO when exposed to an effective amount of moisture or a hydrating liquid. The pH buffer is present in an amount sufficient to render a pH of the moisture or hydrating liquid activatable solid formulation from greater than 4 to about 9.0.Type: ApplicationFiled: February 23, 2021Publication date: June 17, 2021Inventors: Glenn Martin, Andrew P. Hunt, Maria Kim, Mark E. Meyerhoff, Malcolm Kahn
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Publication number: 20210052842Abstract: An NO generating system for nasal inhalation includes a nose vent plug, which includes a nitric oxide (NO) impermeable housing and a receptacle. The NO impermeable housing has integrally formed walls that define a partially enclosed interior portion; two nasal protrusions extending from one of the integrally formed walls and in fluid communication with the partially enclosed interior portion; and an air vent defined in another of the integrally formed walls to introduce air flow into the partially enclosed interior portion. The receptacle is in the partially enclosed interior portion, and contains an NO generating formulation or is to receive an NO generating formulation.Type: ApplicationFiled: April 10, 2020Publication date: February 25, 2021Inventors: Glenn Martin, Mark E. Meyerhoff, Malcolm Kahn
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Publication number: 20200405658Abstract: A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.Type: ApplicationFiled: February 28, 2019Publication date: December 31, 2020Inventors: Joshua C. Doverspike, James Phan, Jianfeng Wu, Chuanwu Xi, Yu Qin, Mark E. Meyerhoff, Yang Zhou
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Publication number: 20200316605Abstract: Provided herein is technology relating to microfluidics and particularly, but not exclusively, to devices, methods, and systems for detecting and/or quantifying analytes in samples using a microfluidic sensor device.Type: ApplicationFiled: April 6, 2020Publication date: October 8, 2020Inventors: Xuewei Wang, Mark E. Meyerhoff, Ryan Castle Bailey
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Publication number: 20200188627Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.Type: ApplicationFiled: April 11, 2018Publication date: June 18, 2020Inventors: Mark E. Meyerhoff, Nicolai Lehnert, Yu Qin, Andrew P. Hunt, Elizabeth J. Brisbois, Hang Ren
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Publication number: 20200164174Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: ApplicationFiled: January 24, 2020Publication date: May 28, 2020Inventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Patent number: 10543337Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: GrantFiled: August 2, 2016Date of Patent: January 28, 2020Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Patent number: 10449321Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.Type: GrantFiled: April 11, 2017Date of Patent: October 22, 2019Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Nicolai Lehnert, Yu Qin, Andrew P. Hunt, Elizabeth J. Brisbois, Hang Ren
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Publication number: 20190307710Abstract: A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.Type: ApplicationFiled: June 10, 2016Publication date: October 10, 2019Inventors: Gergely Lautner, Steven P. Schwendeman, Mark E. Meyerhoff
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Publication number: 20190054038Abstract: An example of a nitric oxide generating formulation includes an S-nitrosothiol (RSNO) powder, a salt, and an additive. The additive is to control or accelerate a rate of release of nitric oxide (NO) from RSNO after the RSNO powder, the salt, and additive are dissolved into a liquid carrier. The nitric oxide generating formulation may be part of a kit that includes a container for dissolving the components into a liquid carrier. One of the kits may be used to prevent and/or treat sinonasal infections and another of the kits may be used to create antimicrobial lock solutions.Type: ApplicationFiled: February 23, 2017Publication date: February 21, 2019Inventors: Mark E. Meyerhoff, Gergely Lautner, Anant Balijepalli, Umadevi Sajjan, Hang Ren
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Patent number: 9872953Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A conductive lead is electrically connected to the working electrode and extends outside of the housing. A reference electrode and/or a counter electrode is electrically isolated from the working electrode. The reference electrode and/or the counter electrode has a first portion that is inside of the housing and a second conductive portion that is outside of the housing. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.Type: GrantFiled: March 28, 2013Date of Patent: January 23, 2018Assignee: The Regents of the University of MichiganInventors: Lajos Hofler, Mark E. Meyerhoff, Dipankar Koley