Abstract: A system and method for operation of an autonomous vehicle (AV) yard truck is provided. A processor facilitates autonomous movement of the AV yard truck, and connection to and disconnection from trailers. A plurality of sensors are interconnected with the processor that sense terrain/objects and assist in automatically connecting/disconnecting trailers. A server, interconnected, wirelessly with the processor, that tracks movement of the truck around and determines locations for trailer connection and disconnection. A door station unlatches/opens rear doors of the trailer when adjacent thereto, securing them in an opened position via clamps, etc. The system computes a height of the trailer, and/or if landing gear of the trailer is on the ground and interoperates with the fifth wheel to change height, and whether docking is safe, allowing a user to take manual control, and optimum charge time(s). Reversing sensors/safety, automated chocking, and intermodal container organization are also provided.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Differentiated service in a federation-based access network is provided by receiving, with a request for access to a wireless network offering at least a two different service levels based on user identities, a set of user credentials from a User Equipment (UE); forwarding, for authentication, the set of user credentials to an identity provider in an identity federation with the wireless network, wherein the identity provider is independent from the wireless network; in response to determining that the set of user credentials indicate a realm known to be associated with a given service level, providing network access to the UE according to the given service level; and in response to determining that the given service level is not a highest service level in the wireless network, transmitting a list of preferred realms to the UE that are associated with higher service levels than the given service level.

Abstract: A method of creating a protective coating on an alkali metal hydroxide-containing solid is provided. The method includes providing carbon dioxide to an alkali metal hydroxide-containing solid and allowing the alkali metal hydroxide and carbon dioxide to react thereby forming a carbonate or bicarbonate-containing layer on the exterior of the solid wherein the carbonate or bicarbonate-containing layer is non-hygroscopic and water soluble, and wherein greater than 80% of the hydroxide in the hydroxide-containing solid does not react with the carbon dioxide, and further wherein the alkali metal hydroxide-containing solid is substantially free of lithium hydroxide. A method of testing for the presence of carbonate-containing coating on an alkali metal hydroxide containing solid is also provided. The method includes exposing the coated solid to 95 weight percent ethanol, collecting the ethanol effluent and testing the effluent for alkali metal hydroxide.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.

Abstract: A toilet assembly includes a flush engine having a bowl defining a sump and a trapway extending from the sump. A bowl insert is configured to be located in the bowl and a shroud is configured to be positioned over the flush engine to conceal at least a portion of the flush engine.

Abstract: A damped compressor used in mobile appliances. The appliances may comprise a compressor which is disposed within a housing and is in fluid communication with a refrigerant system. Within the housing there is an improved damping or stabilizer system which limits movement of electric or mechanical portions, or both, of the compressor within the housing. At startup and shutdown, when oscillations of the components within the housing are generally maximized, the components are limited from contacting the housing internal structure so as to inhibit damage to the compressor and reduce the noise associated with such contact. The components are also damped from movement associated with the mobile application of the compressor.

Abstract: An apparatus for removing flexible material from rotating equipment includes a cutter assembly integrated into the rotating equipment. The cutter assembly includes a cutter shaft, a cutter blade coupled to the cutter shaft, and a movement mechanism configured to move the cutter assembly along an axis of the rotating equipment to cut accumulated material from the rotating equipment.

Abstract: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: An actuator includes a first hinge assembly and a second hinge assembly. The actuator has a first dimension and a second dimension, the first dimension extending through the hinge assemblies. An outer skin is connected to the hinge assemblies. The outer skin defines a first actuator side, a second actuator side residing opposite the first actuator side, and a cavity. Shape-memory material (SMM) members are connected to the opposed hinge assemblies. At least one spring member is positioned within the cavity and structured to exert forces on the opposed first and second actuator sides tending to urge the sides away from each other along the second dimension. When an input is provided to the SMM members, the SMM members change their configurations and cause the actuator to morph into an activated configuration in which the first dimension decreases and the second dimension changes inversely to the first dimension.

Abstract: A remote actuator includes one or more bi-stable strips with at least one shape memory composite (SMC) spring connected to each bi-stable strip. The SMC spring includes a thermoplastic and an electrical and/or thermal conductor for transforming the length of the SMC spring upon heating. The contraction of the SMC spring transforms the bi-stable strip from its coiled stable state to its elongated stable state. The displacement of the SMC spring can be amplified by a simple machine included in the remote actuator. The remote actuator can include a shape memory alloy (SMA) strip for transforming the bi-stable strip from its elongated stable state to it curved stable state upon heating. Heating can be by Joule heating or from an adjacent heat source.

Abstract: A remote actuator includes one or more bi-stable strips with at least one shape memory composite (SMC) spring connected to each bi-stable strip. The SMC spring includes a thermoplastic and an electrical and/or thermal conductor for transforming the length of the SMC spring upon heating. The contraction of the SMC spring transforms the bi-stable strip from its coiled stable state to its elongated stable state. The displacement of the SMC spring can be amplified by a simple machine included in the remote actuator. The remote actuator can include a shape memory alloy (SMA) strip for transforming the bi-stable strip from its elongated stable state to it curved stable state upon heating. Heating can be by Joule heating or from an adjacent heat source.

Abstract: According to an embodiment, an aircraft comprises a fuselage including composite skin; an enclosure located inside the fuselage; a rechargeable battery disposed inside the enclosure; and a ventilation conduit extending from the enclosure to an opening in the composite skin, the ventilation conduit including: a first portion having a first end coupled to the enclosure and a second end spaced from the composite skin, and a second portion extending between the composite skin and the second end of the first portion, the second portion comprising an electrically non-conductive material.

Abstract: According to an embodiment, an aircraft comprises a fuselage including composite skin; an enclosure located inside the fuselage; a rechargeable battery disposed inside the enclosure; and a ventilation conduit extending from the enclosure to an opening in the composite skin, the ventilation conduit including: a first portion having a first end coupled to the enclosure and a second end spaced from the composite skin, and a second portion extending between the composite skin and the second end of the first portion, the second portion comprising an electrically non-conductive material.