Patents by Inventor Mark E. Welker

Mark E. Welker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11286231
    Abstract: Described herein are compounds having a hydrogen-bonding group and optionally a functional group for binding (e.g., covalently binding) the compound to another compound (e.g., hyaluronic acid and/or gelatin). A compound of the present invention may have a structure represented by and/or comprising Formula I, Formula II, Formula III, Formula IV, Formula IV?, Formula V, Formula V?, Formula VI, Formula VII, and/or Formula VIII as described herein. Compositions including compounds of the present invention along with methods of preparing and using the same are also described herein.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: March 29, 2022
    Assignees: Wake Forest University Health Sciences, Wake Forest University
    Inventors: Mark E. Welker, Aleksander Skardal, Amber N. Weissenfluh, Surya Banks
  • Patent number: 10766970
    Abstract: Modified alginates are described herein along with hydrogels comprising the same. A modified alginate may be prepared by reacting alginate and an aromatic compound (e.g., an aromatic amine) and/or pH sensitive compound. The modified alginates, hydrogels, and/or methods described herein may be used to coat and/or encapsulate at least a portion of a bioactive substance, optionally for oral delivery in humans and other animals.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: September 8, 2020
    Assignees: Wake Forest University Health Sciences, Wake Forest University
    Inventors: Mark E. Welker, Emmanuel C. Opara, Surya R. Banks, Amber N. Weissenfluh
  • Publication number: 20190375860
    Abstract: Modified alginates are described herein along with hydrogels comprising the same. A modified alginate may be prepared by reacting alginate and an aromatic compound (e.g., an aromatic amine) and/or pH sensitive compound. The modified alginates, hydrogels, and/or methods described herein may be used to coat and/or encapsulate at least a portion of a bioactive substance, optionally for oral delivery in humans and other animals.
    Type: Application
    Filed: June 30, 2017
    Publication date: December 12, 2019
    Applicants: Wake Forest University Health Sciences, Wake Forest University
    Inventors: Mark E. WELKER, Emmanuel C. OPARA, Surya R. BANKS, Amber N. WEISSENENFLUH
  • Publication number: 20190345096
    Abstract: Described herein are compounds having a hydrogen-bonding group and optionally a functional group for binding (e.g., covalently binding) the compound to another compound (e.g., hyaluronic acid and/or gelatin). A compound of the present invention may have a structure represented by and/or comprising Formula I, Formula II, Formula III, Formula IV, Formula IV?, Formula V, Formula V?, Formula VI, Formula VII, and/or Formula VIII as described herein. Compositions including compounds of the present invention N along with methods of preparing and using the same are also described herein.
    Type: Application
    Filed: October 26, 2017
    Publication date: November 14, 2019
    Inventors: Mark E. Welker, Aleksander Skardal, Amber N. Weissenfluh, Surya Banks
  • Publication number: 20180000743
    Abstract: A novel chemically modified alginate hydrogel has been developed which combines an aromatic compound with a carbohydrate, where the aromatic compound is one or more amines combined with an alginate. The chemical structure of alginate is modified using different amines and different methods, including: (1) covalently bonding aminoethyl benzoic acid to the alginate backbone, and (2) oxidizing the vicinal diol in the alginate chain to an aldehyde before coupling to aminoethyl benzoic acid. Alternatively, the combined aromatic compound and carbohydrate can be a dopamine combined with the alginate.
    Type: Application
    Filed: May 26, 2017
    Publication date: January 4, 2018
    Inventors: Mark E. Welker, Emmanuel C. Opara, Surya Banks
  • Publication number: 20120237533
    Abstract: Compositions and methods for inhibiting the growth of cancer cells, particularly prostate cancer cells are disclosed.
    Type: Application
    Filed: February 6, 2012
    Publication date: September 20, 2012
    Inventors: George Kulik, Mark E. Welker, Freddie R. Salsbury, JR.
  • Patent number: 8110695
    Abstract: The present invention relates to compounds, intermediates, compositions, and methods of making compounds and intermediates related to the compounds of Formula (I) and/or Formula (II) and/or Formula (III) and/or Formula (IV) and/or Formula (VI) and/or Formula (VII) as disclosed herein wherein the various substituents are as defined in the written description.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: February 7, 2012
    Inventors: Mark E. Welker, Ramakrishna R. Pidaparthi
  • Publication number: 20100056801
    Abstract: The present invention relates to compounds, intermediates, compositions, and methods of making compounds and intermediates related to the compounds of Formula (I) and/or Formula (II) and/or Formula (III) and/or Formula (IV) and/or Formula (VI) and/or Formula (VII) as disclosed herein wherein the various substituents are as defined in the written description.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 4, 2010
    Inventors: Mark E. Welker, Ramakrishna R. Pidaparthi
  • Patent number: 6559347
    Abstract: Diels-Alder adducts of dienophiles such as epoxybutene with dienes such as cyclopentadiene and cyclohexadiene are produced by carrying out the Diels-Alder reaction thereof at an elevated pressure. Addional dienophiles disclosed include 2,5-dihydrofuran and derivatives thereof; Additional dienes include isoprene and butadiene. Compounds produced from such reactions are also disclosed.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: May 6, 2003
    Assignee: Wake Forest University Health Sciences
    Inventors: Mark E. Welker, Marion A. Franks
  • Publication number: 20020173668
    Abstract: Diels-Alder adducts of dienophiles such as epoxybutene with dienes such as cyclopentadiene and cyclohexadiene are produced by carrying out the Diels-Alder reaction thereof at an elevated pressure. Addional dienophiles disclosed include 2,5-dihydrofuran and derivatives thereof; Additional dienes include isoprene and butadiene. Compounds produced from such reactions are also disclosed.
    Type: Application
    Filed: February 8, 2002
    Publication date: November 21, 2002
    Inventors: Mark E. Welker, Marion A. Franks
  • Patent number: 6380447
    Abstract: Diels-Alder adducts of dienophiles such as epoxybutene with dienes such as cyclopentadiene and cyclohexadiene are produced by carrying out the Diels-Alder reaction thereof at an elevated pressure. Addional dienophiles disclosed include 2,5-dihydrofuran and derivatives thereof; Additional dienes include isoprene and butadiene. Compounds produced from such reactions are also disclosed.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: April 30, 2002
    Assignee: Wake Forest University
    Inventors: Mark E. Welker, Marion A. Franks
  • Patent number: 6242478
    Abstract: Disclosed are novel sulfenate esters and thiosulfinate esters that induce the expression of metabolic enzymes, particularly Phase II enzymes such as glutathione-s-transferase, DT-diaphorase and Ferritin H when administered to a subject. Also disclosed, such compounds are effective to displace a zinc ion from retroviral zinc finger nucleocapsid proteins effective to inhibit HIV replication. The present invention is further directed to novel methods of making these compounds, and any compounds produced by the process of making these novel compounds.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: June 5, 2001
    Assignee: Wake Forest University
    Inventors: Mark E. Welker, Suzy V. Torti, Frank M. Torti, Alan J. Townsend, Eva Pietsch, Allison L. Hurley