Patents by Inventor Mark Edward Fortini

Mark Edward Fortini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Manipulation of non-terminally differentiated cells using the Notch pathway
    Publication number: 20040058443
    Abstract: The present invention is directed to methods for the expansion of non-terminally differentiated cells (“precursor cells”) using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.
    Type: Application
    Filed: April 18, 2003
    Publication date: March 25, 2004
    Applicant: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Mark Edward Fortini, Kenji Matsuno
  • Manipulation of non-terminally differentiated cells using the notch pathway
    Patent number: 6149902
    Abstract: The present invention is directed to methods for the expansion of non-terminally differentiated cells ("precursor cells") using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: November 21, 2000
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Mark Edward Fortini, Kenji Matsuno
  • Manipulation of non-terminally differentiated cells using the notch pathway
    Patent number: 5780300
    Abstract: The present invention is directed to methods for the expansion of non-terminally differentiated cells ("precursor cells") using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: July 14, 1998
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Mark Edward Fortini, Kenji Matsuno