Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.

Abstract: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

Abstract: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.

Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.

Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.

Abstract: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

Abstract: In accordance with an exemplary embodiment of the present invention, an optical device includes an interleaver/deinterleaver, which includes a passive thermal compensator, wherein an optical signal which transverses the optical device undergoes substantially no temperature induced frequency drift over a desired temperature range.

Abstract: Self-referencing optical sensors and methods are described herein that can be used to detect bio-chemical interactions (e.g., biological binding of antigen-antibody pairs) that occur in for example a microplate. In one embodiment, the self-referencing optical sensor includes a substrate, a lower (reference) waveguide grating structure, a buffer layer and an upper (sensing) waveguide grating structure. This self-referencing optical sensor enables an optical interrogation system to detect a bio-chemical interaction independent of the effect of temperature by measuring a reference signal associated with the lower (reference) waveguide grating structure and measuring a sensing signal associated with the upper (sensing) waveguide grating structure. These two signals are then subtracted from one another to determine a sensing measurement that represents whether or not the bio-chemical interaction occurred that is independent of the effect of temperature.

Abstract: In accordance with an exemplary embodiment of the present invention, an optical device includes a first element which decomposes said optical signal into a first beam and a second beam with the first beam being in a first polarization state and the second beam being in a second polarization state. The first and second polarization states being orthogonal to one another and including each of said multiple channels. The optical device further includes a second element which transforms the first beam into a first elliptically polarized state having odd channels in a third polarization state and even channels in a fourth polarization state having even channels in the third polarization state and odd channels in the fourth polarization state; and a third element which combines the odd channels into a first output port and the even channels into a second output port.

Abstract: The present invention is a modular optical switch fabric that includes optical modules that are inserted into an optical chassis by way of plug-in electrical connectors. Each optical module includes a collimator panel and a beam steering panel secured to a frame member. The frame member is configured to position the collimator panel in fixed optical alignment relative to the beam steering panel. The modular optical switch fabric is upgradeable. The optical switch fabric allows users to expand the switch fabric capacity by simply adding switch fabric modules. The optical switch fabric also features modules that can be replaced and repaired without causing interruptions in service.

Abstract: An optical reading system is described herein which can be used to detect the presence of a biological substance (e.g., cell, drug, chemical compound) on a surface of a grating-based waveguide sensor. In one embodiment, the reading system includes a light source (e.g., laser, diode) for directing a light beam into the grating-based waveguide sensor and a detector (e.g., spectrometer, CCD imaging device) for receiving a reflected light beam from the grating-based waveguide sensor and analyzing the reflected light beam so as to detect a resonant wavelength/angle which corresponds to a predetermined refractive index that indicates whether a biological substance is located on the surface of the grating-based waveguide sensor.

Abstract: An optical fiber clamp that precisely aligns and clamps multiple optical fibers in multi-channel freespace optical systems, eliminates multiple parts and simplifies assembly. Multiple wafers each having an array of holes passing therethrough, are aligned with respect to each other. Optical fibers are passed through the holes, and at least one of the wafers is moved laterally with respect to the other wafers, so that sidewalls of the holes clamp the optical fibers into a desired location.

Abstract: The present invention relates to a collimator assembly for use in an optical switch. The collimator assembly includes an integrated LED/photodiode plane disposed in a dual microlens array. The integrated LED/photodiode plane results in a relatively simple way to manufacture high port count collimator arrays with integrated monitoring capabilities. The LED/photodiode plane can be readily produced using standard electronics manufacturing technology.

Abstract: The present invention is a three-dimensional optical cross-connect switch that includes a first optical switching array and a second optical switching array. When combined, the first and second arrays have collimator tiles and beam steering tiles disposed in a checker-board arrangement. The maximum deflection angle of the switch is less than or equal to the maximum deflection angle of either individual switching array. The tiling scheme of the present invention effectively increases the port count of a three-dimensional optical cross-connect switch without increasing the angular deflection required to access all of the pixels in the switch.

Abstract: The present invention relates to a collimator assembly for use in an optical switch. The collimator assembly includes an integrated LED/photodiode plane disposed in a dual microlens array. The integrated LED/photodiode plane results in a relatively simple way to manufacture high port count collimator arrays with integrated monitoring capabilities. The LED/photodiode plane can be readily produced using standard electronics manufacturing technology.

Abstract: A tunable, reconfigurable optical add/drop multiplexer comprises a first signal routing component and at least one wavelength selective switch having an input port and an output port. The input port is optically coupled to the first signal routing component. The wavelength signal selective switch is wavelength tunable, so as to allow a selected wavelength to be routed to the first signal routing component and the rest of the wavelengths to be routed to the output port. According to an embodiment of the present invention the first signal routing component is an optical circulator.

Abstract: In accordance with another exemplary embodiment of the present invention, an optical device includes an interleaver/deinterleaver, which includes a passive thermal compensator, wherein an optical signal which traverses the optical device undergoes substantially no temperature induced frequency drift over a desired temperature range.

Abstract: An optical fiber clamp that precisely aligns and clamps multiple optical fibers in multi-channel freespace optical systems, eliminates multiple parts and simplifies assembly. Multiple wafers each having an array of holes passing therethrough, are aligned with respect to each other. Optical fibers are passed through the holes, and at least one of the wafers is moved laterally with respect to the other wafers, so that sidewalls of the holes clamp the optical fibers into a desired location.

Abstract: The present invention is a modular optical switch fabric that includes optical modules that are inserted into an optical chassis by way of plug-in electrical connectors. Each optical module includes a collimator panel and a beam steering panel secured to a frame member. The frame member is configured to position the collimator panel in fixed optical alignment relative to the beam steering panel. The modular optical switch fabric is upgradeable. The optical switch fabric allows users to expand the switch fabric capacity by simply adding switch fabric modules. The optical switch fabric also features modules that can be replaced and repaired without causing interruptions in service.